An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.

An injector apparatus includes a housing (10.sup.1, 10.sup.2) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.

The present disclosure relates to an apparatus for providing access to bone marrow and delivering a quantity of fluid to an intraosseous space. The apparatus may include a driver having a housing and a drive shaft, and a plunger operating and cartridge drive mechanism for releasably retaining a portion of a cartridge assembly having a plunger assembly. A plunger operating assembly may be disposed within a longitudinal bore of the plunger operating and cartridge drive mechanism. The plunger operating assembly may include a plunger barrel having a chamber configured to receive a portion of the plunger assembly of the cartridge assembly. The apparatus may also include a drive housing for transmitting rotational forces from the drive shaft to the cartridge assembly.

A tip cap assembly adapted to close a fluid passageway of a distally projecting tip of an injection system, said tip cap assembly including an elastomeric inner cap having a frustoconical protrusion extending proximally and having a proximal face; a rigid outer cap which is securely disposed around said elastomeric inner cap; the proximal face of the frustoconical protrusion having a diameter at least greater than the diameter of the fluid passageway of the injection system.

One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

An object of the present invention is to provide a medical rubber composition having excellent non-elution characteristic and gas permeability. The present invention provides a medical rubber composition containing: (a) a butyl rubber, (b) a diene-based rubber containing polybutadiene, (c) a peroxide-based crosslinking agent, and (d) a co-crosslinking agent, wherein an amount of (b) the diene-based rubber in 100 parts by mass of the rubber component composed of (a) the butyl rubber and (b) the diene-based rubber is 15 parts by mass or more and 90 parts by mass or less, and a mass ratio ((d)/(c)) of (d) the co-crosslinking agent to (c) the peroxide-based crosslinking agent is 1.2 or more and 25 or less.

An injector apparatus includes a housing (10.sup.1, 10.sup.2) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

A drug delivery system for injecting a medicament is provided. The system includes a container configured to receive a medicament; a drive assembly which, upon actuation, is configured to expel the medicament from the container; a needle for injecting the medicament to a patient; a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and a tube crimping arrangement configured to engage the tube to block fluid flow through the tube. The drive assembly causes the tube crimping arrangement to engage the tube after a dose of the medicament has been delivered to the patient through the needle.

A receptacle includes an elongate barrel section defining a barrel length between an axial position p.sub.A and an axial position p.sub.B; side walls each having an inner surface bordering an interior; a layer of a lubricant located on the inner surface; and a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls. An axial position p.sub.+ is the axial position closest to p.sub.B at which the charge contacts the layer or the inner surfaces and an axial position p.sub.− is the axial position closest to p.sub.A at which the charge contacts the layer or the inner surfaces. The distance between p.sub.B and p.sub.+ divided by the distance between p.sub.+ and p.sub.A is in a range from 0 to 2 and a mean thickness of the layer between p.sub.A and p. is at least 10 nm.