The single-use safety syringe having a manual and/or automatic retracting needle preventing re-use thereof comprises a needle, a piston with a tightening seal and a cylindrical body having, at an end thereof, a connector provided with a calibrated attaching hole for the needle and open, at another end thereof, for inserting the piston, comprising, internally of the cylindrical body, a separating seal of a first chamber comprised between the separating seal and the connector in which a first active ingredient is positioned and a second chamber comprised between the separating seal and the tightening seal in which a second active ingredient is positioned, the separating seal having a connecting channel between the first and second chamber, closed by a pressure limiting valve, first engaging means further being provided, activatable for engaging the separating seal to the needle and second engaging means activatable for engaging the separating seal to the piston.

An injection device includes a cylinder having a cavity for receiving a liquid. A passage is connected to the cavity for inflow and/or outflow of the liquid. The passage can be connected to an injection component. A shut-off valve has a valve body and a flexible sealing ring with an opening. The valve body, proceeding from a release position in which the passage is freed, is at least partially movable through the opening of the sealing ring to a blocking position in which the valve body engages behind the opening so that movement of the valve body to the release position is blocked and the passage is sealed off against proximally directed flow. An adapter body is connected to the cylinder. The shut-off valve is arranged at a proximal end of the adapter body and at a distal end of the cylinder. The device can be used in a syringe.

The present invention relates to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

An air removal apparatus for an autoinjector is disclosed. The air removal apparatus can remove or trap air within the autoinjector, preventing the removed or trapped air from displacing medicament or being injected into the patient. The air removal apparatus removes or traps air by creating a vacuum. The vacuum can remove air from the medicament and can trap air within a section of the auto injector that is separated from the medicament.

Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed. The system may include transfer apparatus and an injection device. The transfer apparatus may have receiving stations for a drug source, such as a vial or vial holder, and for an injection device, and fluid flow pathways for transferring drugs from the source into the injection device. The injection device may include an expandable elastic bladder and an injection cannula that is movable between a plurality of positions.

The present invention relates to a filtering syringe, and more particularly, to an apparatus obtained by improving a syringe provided with a filter means for filtering foreign substances such as glass fragments of an ampoule, so as to prevent an injection needle or an injection flow passage from being contaminated with the foreign substances while allowing a liquid medicine to be smoothly sucked with a smaller force. The filtering syringe is configured such that the injection needle or the injection flow passage is isolated from the suction flow passage which is upstream of the filter means and in which the foreign substances may remain together with the liquid medicine, thereby allowing the liquid medicine to be sucked with a force less than that required for a conventional syringe and thus maximizing user's convenience and marketability of the syringe.

A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.

The bypass syringe is used in combination with an expandable or inflatable bladder or balloon that is circumferentially wrapped around a patient designed to reduce bleeding from a skin insertion wound site and a vascular wound site after a vascular intervention or surgical procedure is performed. The bypass syringe is designed to pre-inflate the balloon, allow the balloon to relax based on how tightly the band is wrapped around the patient, and then be inflated with a volumetric amount of fluid. The bypass syringe's pre-inflation step will reduce complications caused by variabilities in band securement or tightness. A pre-inflation step combined with a venting of excess air step or controlled pressure inflation steps will absorb/take up/consume excess space caused by variability in band securement and help to reduce complication caused by securement variability.

A medical device may include a shalt extending between a proximal end and a distal end. The shaft may include a lumen therein. The medical device may include a handle coupled to the proximal end of the shaft and may include a mode selector. The mode selector may be adapted to transition between a first mode and a second mode of the medical device. The medical device may further include a compressed fluid source. In the first mode, the compressed fluid source may he coupled with the shaft so as to impart a negative pressure in at least a portion of the lumen. In the second mode, the compressed fluid source may be fluidly coupled with the shaft so as to impart a positive pressure in the at least a portion of the lumen.

Provided is an epidural device configured to inhibit or substantially or completely prevent further progression of an epidural needle upon entry of the needle into the epidural space. When the needle is inserted into the ligamentum of the patient's back, the device may be pressurized with fluid using the resistance of the dense ligament to maintain pressure. This pressurization may lock a pushing mechanism in place relative to the needle such that the pushing mechanism can be used to advance the needle. Once the epidural space is reached, the fluid (e.g., saline or air) enters the epidural space, and the release of pressure may cause the trigger mechanism to disengage from the sliding pusher, allowing the pusher to slide along the body of the construct. The device thus may provide the ability to detect the epidural space using pressure loss while preventing the needle from advancing into the dura once the space is reached. In a preferred aspect, the device may prevent premature triggering when there is a slow flow of fluid from the epidural needle into the surrounding tissue.