Syringes, assemblies for use in a filling process, and related methods of manufacture are disclosed. A syringe may include a reservoir filled or configured to be filled with a preselected volume of a drug, including, for example, a preselected volume of 3 mL or approximately 3 mL of the drug. The syringe may further include a wall comprising a cylindrical portion. The cylindrical portion of the wall may include: (a) an inner diameter equal to or approximately equal to a standard inner diameter of a 5 mL syringe or a standard outer diameter of any other syringe volume not equal to the preselected volume or 3 mL; and/or (b) an outer diameter equal to or approximately equal to a standard outer diameter of a 5 mL syringe or a standard outer diameter of any other syringe volume not equal to the preselected volume or 3 mL.

A needleless injector for performing a subcutaneous injection without a needle. The needleless injector has a drive end having a drive spring for driving a piston system against a plunger to push liquid out a nozzle of an ampoule with sufficient velocity to deliver a subcutaneous injection without a needle.

A single use pre-filled delivery device is disclosed having a deformable container including a side wall having an inside surface defining a chamber for retaining fluid, a clip element, and a locking element. The deformable container further includes a closed proximal end and an open distal end including a male luer tip having a passageway therethrough providing fluid communication with the chamber. The male luer tip may be removably connectable to a female luer connection of a vascular access device. The clip element includes a distal end, proximal end, and a pivot located between the distal end and the proximal end of the clip element for collapsing the deformable container to drive fluid out of the chamber by movement of the proximal end towards the distal end. The pivot may be a hinge, which may be in the form of a living hinge. The deformable container may be attached to the clip element. The locking element may be disposed on the clip element. A method of administering a fluid to a vascular access device using a single use pre-filled delivery device as described herein is also disclosed.

Syringes which are suitable for dispensing and injecting medical foams for sclerotherapy are described and claimed. The syringes of the invention comprise a syringe barrel having a nozzle and a bore to receive a syringe plunger; a syringe plunger defined by a front end and a rear end connected by a tubular walls and having an internal hollow duct between the front end and the rear end, and through which foam can flow; and an injectate chamber formed by insertion of the front end of the plunger into the barrel. The syringes comprise a flow-disruptor arranged to modify the flow of foam as it enters the injectate chamber. In certain embodiments the syringes comprise waste chambers which capture and retain poor quality foam. The syringes are particularly useful for dispensing foams made with little or no nitrogen content and are configured to reduce the risk of air contamination during dispensing the foam. Kits comprising the syringes together with a suitable source of foam and methods of dispensing foam form further aspects of the invention.

A gas sterilizable syringe includes an enclosure having walls that define a fluid chamber. A flowable material is disposed within the fluid chamber of the enclosure. A plunger is assembled with the enclosure and is moveable toward a distal end of the enclosure for dispensing the flowable material. One or more apertures are formed in at least one of the walls of the enclosure. A gas permeable barrier covers at least one of the apertures formed in at least one of the walls of the enclosure for enabling sterilization gases to pass through the at least one aperture covered by the gas permeable barrier while preventing the flowable material from passing through the at least one of aperture. The gas permeable barrier is permeable to the sterilization gases and impermeable to the flowable material disposed within the fluid chamber of the enclosure.

A system for sterilizing a drug delivery device includes a drug delivery device having a first self-healing seal configured to seal a fluid reservoir disposed within the drug delivery device. A sealable container is configured to receive the drug delivery device therein. The sealable container has a base portion and a cover portion. The cover portion has a second self-healing seal positioned to align with the first self-healing seal when the drug delivery device is disposed within the sealable container. A fill port includes a fill path, the fill path being configured to pass through the first and second self-healing seals to fluidly couple the fill port to the reservoir of the drug delivery device. Other systems, methods, and devices of sterilization are also disclosed.

A method of assembling a drug delivery device, comprising the steps of: inserting a piston rod in a nut portion of a cartridge assembly and rotating the piston rod until the piston rod distal end engages the cartridge piston, mounting a drive member on the piston rod in a rota-tional position being closest to a pre-determined rotational position, and rotating the drive member to the pre-determined rotational position.

An injection device for injecting a substance into a body, including a syringe having: a needle, a barrel, a stopper, a plunger rod, moveable from an initial position to a final position, a needle shield, moveable at least from a retracted position to a safety position, a locking unit, arranged to lock the needle shield into the safety position, a locking actuator moveable at least: from a non-actuating position, into which the locking unit is in an open mode, to an actuating position, into which the locking actuator is arranged to put the locking unit in closed mode so that the needle shield can be locked into the safety position.

Various systems and methods for the pressure-regulated transfer of medical fluids are disclosed. The system can include an adapter assembly that connects with a medical container and with a syringe assembly. The syringe assembly can include a first reservoir and a second reservoir. In various embodiments, when the adapter assembly and the syringe assembly are coupled, the first reservoir and the container can exchange regulating fluid and the second reservoir and the container can exchange medical liquid from the medical container.

A syringe assembly for a drug delivery device. The syringe assembly includes a syringe barrel having a proximal end, a distal end, and a longitudinal axis. A needle assembly is operatively coupled to the syringe barrel and includes a needle hub and a needle attached to the needle hub. A flexible connection is disposed between the syringe barrel and the needle hub and forms a fluid pathway between the syringe barrel and the needle. The flexible connection enables the needle assembly to be moveable from a filling position, in which a longitudinal axis of the needle assembly is parallel to a longitudinal axis of the syringe barrel, to an assembled position, in which the longitudinal axis of the needle assembly is not parallel to the longitudinal axis of the syringe barrel.