An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, a surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness, the inner surface of the barrel having a surface roughness Ra of less than 100 nm.

The present invention relates to a signal delaying assembly for a medicament delivery device, said assembly comprising a delay female member containing a fluid, a delay male member having at least one passage, a delay unit connected to the delay female member or to the delay male member, wherein a relative movement between the male member and the female member and towards each other causes the transfer of said fluid from said female member through the at least one passage for slowing said movement, characterized in that the delay unit is releasably connected to a signal generating assembly for delaying at least one feedback signal.

A puller assembly for removing a shield from around a needle of a syringe. The puller assembly includes a grip component and a cap. The grip component has a tubular body defining an interior hollow which axially receives the shield. The tubular body has a slit that allows it to be forcibly shifted from a first arrangement to a second arrangement to change the size of the interior hollow. The tubular body includes a radial inner face with at least one radial inward projection for directly engaging the shield. The cap is grippable by a user. The grip component is held by the cap when inserted within a cavity of the cap during manufacturing installation, and when so held at least one radial inward projection of the grip component engages the shield for removal of the shield from around the needle when the cap is moved. A method of mounting a puller assembly to a shield around a needle is also disclosed.

An automatic injection device with flow regulation is disclosed. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection needle also has a fluid path which fluidly connects the drug container to the patient via an insertion device, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and the pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism. The potential energy source may be a spring that surrounds the drug container and may be magnetically coupled to the plunger. The clock escapement mechanism is configured to control the spring at a regulated rate over a time interval using a gearbox and rotational-to-linear translator comprising a rack and a pinion.

A multi-chamber syringe for delivering a plurality of fluids to a central venous catheter includes a barrel and a plunger. The barrel includes a plurality of chambers, and a first one of the plurality of chambers has a predefined volume of a saline flush stored therein. Actuation of the plunger causes the predefined volume of the saline flush to be dispensed from the barrel into the central venous catheter.

A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector. The pawl element and/or gear element comprises a noise reduction characteristic at a surface which dampens the noise produced.

Exemplary embodiments provide wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates, for example, in a single bolus. Exemplary embodiments provide methods for assembling wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates. Exemplary embodiments provide methods for using wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates.

An injection device, method, and system for drug delivery includes a container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug; an injection drive mechanism having a plunger for acting on the stopper and an energy source having a first selected potential energy for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug; and a plunger loading mechanism for substantially preventing the plunger from accelerating to a predetermined velocity before it acts on the stopper. The plunger loading mechanism may be a spring having a second selected potential energy for reducing or eliminating a distance between the plunger and the stopper, prior to the plunger accelerating to the velocity. The second selected potential energy of the spring may be less than the first selected potential energy of the energy source.

The present invention relates to a medicament delivery device comprising: a housing (10, 16) having a distal and an proximal end, said housing being adapted to receive a medicament container (18) with a delivery member (20) or with a connectable delivery member for delivery of a medicament; a drive mechanism (54) arranged to act on a plunger rod (58), which plunger rod (58) in turn is arranged to act on the medicament container (18) for providing automatic delivery of the medicament; a release mechanism (62) interactively connected to the drive mechanism (54) for releasing the drive mechanism (54) from a pre-tensioned state; a signal generating mechanism (90) for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely delivered, which signal generating mechanism (90) is operably connected to said drive mechanism such that it is arranged movable in a longitudinal direction in relation to said drive mechanism (54), that said drive mechanism (54) is arranged with a signal release mechanism (111) capable of activating said signal generating mechanism (90) at a certain longitudinal position of said drive mechanism after its release, for generating an audible and/or tactile and/or visual signal, wherein said signal generating mechanism (90) comprises a signal delay mechanism (105) operably arranged to delay the generation of signal after activation of said signal generating mechanism (90).