Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. Dual-lumen tubing coupled to the cartridge at a first end includes a fluid line and a vent line attached, at a second end, to a connector for a receiving container for a compounded drug.

Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

A plunger head for a medication injection device includes a first ultrasonic transducer coupled to emit ultrasonic signals, where the first ultrasonic transducer is oriented within the plunger head to send the ultrasonic signals along a length of a barrel of the medication injection device when the plunger head is disposed in the barrel. A second ultrasonic transducer is disposed within the plunger head and oriented to receive reflections of the ultrasonic signals. A controller is disposed in the plunger head and coupled to the first ultrasonic transducer and the second ultrasonic transducer. The controller includes logic that when executed by the controller causes the controller to perform operations including instructing the first ultrasonic transducer to emit the ultrasonic signals.

An apparatus can aid usage of a plunger, for example helping a medical practitioner use a hypodermic syringe to inject dermal filler. The apparatus can fasten a thumb rest of a plunger of the syringe to a thumb of the practitioner and can support one-handed operation of the syringe. With the plunger so fastened, reverse thumb motion can retract the plunger for aspiration, and forward thumb motion can advance the plunger for injection. The apparatus can comprise a member extending at least partially around the practitioner's thumb. The member can comprise an aperture configured to retain the thumb rest between the thumb and the member, with a shaft of the plunger passing through the aperture.

Provided herein are needle assemblies for intravitreal injection of an implant into an eye of a patient through an unsheathed state and a sheathed state. Such needle assemblies are precise and accurate for proper treatment and prevent further damage to the eye.

One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

In an embodiment, a resettable injection training device and a method embodiment for resetting the device is provided herein. The device may include a housing having a proximal end and a distal end, the housing defining a cavity there within. A plunger may be slidable relative to the housing between the proximal end and the distal end. A releasably locking shield having a proximal end and a distal end, and being slidably engaged with the housing is also provided. The shield may be slidable between a retracted, pre-use position an extended, locked, post-use position. The device may further include a flat biasing member for locking the shield in the extended position, and a compressing component slidable relative to the housing, wherein pressure on the flat biasing member from the compressing component deforms the flat biasing member, and unlocks the shield, and wherein a release of pressure by the compressing component on the flat biasing member locks the shield in an extended, post-use position.

A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (S), when the piston (36) is in its rear end position, can release the piston rod (35, 135) in a dispensing operation, and therefore the piston (36) moves counter to the first direction as far as its front end position because of the applied pretension and, in the process, fluid in the cylinder (16, 116) is dispensed via the nonreturn valve (18) for administering, wherein the cylinder (16, 116) together with the nonreturn valve (18) is in the form of an exchangeable front assembly (13, 14) which is releasably connected to the receiving block (10).

A system for injecting includes a syringe body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body, the plunger member. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the syringe body. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. The needle is at least partially retractable into plunger interior. The needle proximal end feature includes an annular distally facing surface.

A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (S), when the piston (36) is in its rear end position, can release the piston rod (35, 135) in a dispensing operation, and therefore the piston (36) moves counter to the first direction as far as its front end position because of the applied pretension and, in the process, fluid in the cylinder (16, 116) is dispensed via the nonreturn valve (18) for administering, wherein the receiving block (10) is in the form of an integral receiving block (10) which is produced by an additive production method.