The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a tool to screen, detect, diagnose and/or monitor relative olfactory deterioration resulting from Alzheimer's disease. A preferred embodiment comprises cascading aromas by serially administering more than one pure odorant to the patient's nostrils, left vs right, with measurement of the time, or numbers of breaths, required to cognitively notice the pure odorants' presence.

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.

An aerosol-generating system may include a liquid storage portion configured to hold liquid aerosol-forming substrate, a vaporizer including a heating element with an internal passage at least partially defined by a surface of the heating element, and a micro pump configured to deliver liquid aerosol-forming substrate from the liquid storage portion to the internal passage of the heating element, such that the vaporizer is configured to heat the delivered liquid aerosol-forming substrate at the internal passage to a temperature sufficient to volatilize at least a part of the delivered liquid aerosol-forming substrate. The micro pump may be configured to deliver a particular amount of liquid aerosol-forming substrate to the internal passage based on the micro pump performing an individual pump cycle.

Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine urge relief.

Inhalation actuator (6), having a receptacle (5) for receiving a discharge pipe (4) of an inhalant reservoir (1), an inhalant nozzle (9) for spraying inhalant from at least one nozzle outlet opening, an inhalant delivery system (8) for delivering inhalant from the discharge pipe to the inhalant nozzle, a baffle element (10) onto which inhalant can be sprayed in a straight line from the nozzle outlet opening, an aerosol chamber (12) with an internal volume to which inhalant sprayed from the inhalant nozzle can be delivered, wherein the aerosol chamber has an aerosol outlet (11), which has a local narrowing, for dispensing aerosol from the aerosol chamber, and an air delivery system (13) separate from the inhalant nozzle and from the aerosol outlet. Inhalation device having the inhalant reservoir with a pressurized container (2), and having the inhalation actuator, wherein the inhalation actuator does not need to have the local narrowing. Insert (21) for inserting into the mouthpiece (18) of an inhalation actuator, the insert having: centring means for centring the insert in the mouthpiece, a wall (25) which is arranged transversely with respect to the insertion direction and which is arranged upstream of the centring means in the insertion direction, an inhalant inlet opening (24) provided in the wall, a baffle element, which is arranged upstream of the inhalant inlet opening counter to the insertion direction, a surface which is arranged transversely with respect to the insertion direction, next to the baffle element, and though which aerosol can flow freely in the insertion direction, an air inlet (13) arranged upstream of the free-flow surface in the insertion direction, and an aerosol outlet which is arranged upstream of the free-flow surface counter to the insertion direction.

Aspects and embodiments of the present invention generally include a device for patient self-administration of a prescribed medication. The device makes available for administration the precise quantity of medication constituting a dose at times designated by a health care provider (HCP). Preferably, the device also detects and transmits information to a remote management system accessible to the HCP, including detected attempts to tamper with the device. Advantageously, HCPs may render oversight and control over the device and its use to mitigate risks associated with patients self-administering medication without in-person supervision. This control may include establishing prerequisites the patient must meet prior to a dose being made available, or remote deactivation of the device. This oversight by the HCP may include patient-specific and aggregate data analysis for optimization of treatment or evaluation of the safety and efficacy of a treatment. Furthermore, this oversight may be conducted via a web-based interface.

What is proposed is a nasal dispenser (10) for the nasal application of liquids in atomized form, in particular for children.

The nasal dispenser (10) has a nasal applicator (40) which is for dispensing the liquid and is formed by an outer component and an inner component, which together define a vortex chamber and at least one inlet channel into the vortex chamber.

In the case of components that are stationary in relation to one another, especially tapered inlet channels (96) for generating a high liquid velocity in the vortex chamber (98) are proposed. The cross-sectional area of the inlet channel (96), that is aligned transversely to the flow direction (4) in the inlet channel, at its narrowest point or the sum of the cross-sectional areas of the inlet channels, that are aligned transversely to the flow direction (4) in the inlet channels (96), at their respective narrowest points is at most 0.05 mm.sup.2.

In the case of a design in which the inner component (60) is arranged movably in the outer component (50), in particular for the purpose of obtaining a valve function, it is conversely proposed to design the outlet opening (54) with a narrowest cross section of at most 0.05 mm.sup.2.

A nebulizer device includes an air intake port positioned downstream of a nebulizer element, and a mouthpiece positioned upstream of the nebulizer element. A flow sensor is coupled to a controller. The controller is configured to integrate an inhaled air flow signal received from the flow sensor for determining an inhaled air volume. The controller is also configured to turn on the nebulizer element when the inhaled air volume reaches a first predetermined threshold, and turn off the nebulizer element when the inhaled air volume reaches a second predetermined threshold. A method for targeted delivery of aerosolized particles to the lungs is also disclosed.

An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.