A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body (201) and a cartridge (203) with a plurality of powder compartments (205) each including one dose of a drug. The body (201) has an opening (204) shaped for receiving the cartridge (203) and the plastic body recess (215) and the detent (218) to allow a controlled advancement and turning movement of the cartridge (203) relative to the body (201) for sequentially delivering each of the plurality of unit doses filled into the cartridge compartments (205). The inhaler construction is suitable for filling the plurality of unit doses into the compartments (205) with the cartridge (203) assembled into the body (201). The invention affords a large dose inhaler of single-use and low cost that improves industrial filling and manufacturing cost for the delivery of high dosages of inhaled medicines.

A stable dry powder composition for inhalation includes acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) in a range of about 1 μm to about 5 μm. The dry powder composition may contain a pharmaceutically acceptable excipient, such as a stearate, in an amount ranging from about 0.04% (w/w) to about 0.06% (w/w), or from about 0.4% (w/w) to about 0.6% (w/w), of the composition.

A method for controlling a vaporizer device may include determining a first temperature, vaporizing an inhalable substance at the first temperature, raising the first temperature by a temperature quantity, wherein a second temperature is a sum of the temperature quantity and the first temperature; and vaporizing the inhalable substance at the second temperature, wherein the temperature quantity is less than 3° C.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

A method for controlling a vaporizer device may include determining a first temperature, vaporizing an inhalable substance at the first temperature, raising the first temperature by a temperature quantity, wherein a second temperature is a sum of the temperature quantity and the first temperature; and vaporizing the inhalable substance at the second temperature, wherein the temperature quantity is less than 3° C.

A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.

Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed.

An inhaler housing comprising a receiving portion adapted to at least partially receive a container containing a medicament, and a dispensing portion through which the medicament is dispensed, wherein the receiving portion and the dispensing portion are movable relative to one another between a storage condition in which the receiving portion and the dispensing portion at least partially overlie one another and a use condition.

An inhalation delivery device for dry powder with adjusting resistance through detachable heads, which combines four different detachable heads and uses a single base. The desired resistance and the medicament delivery/allocation to the lungs, are set, offering a practical, low cost solution while, at the same time, a high performance personalized treatment. The detachable head (1) comprises a mouthpiece (2) for the mouth of the patient, a medicament intake orifice (3) sized to fit into the mouth of a patient and a protrusion (4) for a sliding connection between the detachable head (1) and the base (5), via notches (6) carried by the base (5). Each detachable head (1) possesses a corresponding protrusion (4) which may be fitted onto the base (5). The device comprises typically four different heads (1), covering the entire spectrum of patients accordingly to their inhalation capacity, the medicament type/dose and the targeted point of treatment.

An elongate aerosol generation device having a housing includes: a top end at which an aerosol is provided; a bottom end which is opposed to the top end; and four sides between the bottom end and the top end in a substantially quadrilateral arrangement of two larger opposing sides and two smaller opposing sides. The bottom end is adapted such that the device can stand on the bottom end, and the four sides are smoothly curved in a direction from the bottom end to the top end.