The present disclosure concerns an assembly for a drug delivery device (1)comprising a housing (3), a first abutment surface (64), a second abutment surface (21), and a detachable member (7) which is detachable from the housing (3) and attachable to the housing (3), wherein the assembly is configured such that, during detachment of the detachable member (7) from the housing (3) for an Nth time, N being a predetermined number, the first abutment surface (64) is brought into abutment with the second abutment surface (21), wherein the assembly is configured such that, when the first abutment surface (64) abuts with the second abutment surface (21), the detachable member (7) is enabled to be reattached to the housing (3) and, afterwards, the detachable member (7) is prevented from being detached from the housing (3).

An upper-assembly electronic cigarette atomizer is provided. The atomizer may include a liquid storage cup having an upper opening, and a head cover component connected with the upper opening in a threaded manner. The liquid storage cup and the head cover component may form a closed space for containing an e-liquid. The head cover component may be configured to be detached from the liquid storage cup as an integral unit. An electronic cigarette containing an upper-assembly electronic cigarette atomizer and a method of assembly are also provided.

The invention relates to an inhaler, in particular an electronic cigarette product, comprising at least one evaporator unit with at least one electric evaporator for evaporating liquid supplied to the evaporator and comprising an electronic controller for controlling and/or regulating the at least one evaporator unit. The inhaler has at least one replaceable cartridge, wherein the cartridge has the evaporator unit and a liquid tank which is connected or can be connected to the evaporator unit.

A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG. 10. The operation counter comprises a lead screw and an associated rider both supported by the housing part.

A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

A vaporizer device includes a resistive heating element; circuitry configured to control delivery of electrical power to the resistive heating element from a power source; and a controller configured to perform operations including: receiving inputs representative of a power delivery to the resistive heating element, a temperature of the resistive heating element, and/or a flow rate of air past the resistive heating element; predicting, using the received inputs, an amount of evaporation of the vaporizable material at the resistive heating element; and controlling the power delivery to the resistive heating element in response to the predicted amount of evaporation of the vaporizable material, the controlling including increasing or decreasing an instantaneous power delivery to the heating element such that a target aerosol yield is produced. Related devices, systems, methods, and articles are also described.

An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.

Fit testing is conduct to ensure that gas mask provide proper protection to workers that may be exposed to airborne contamination. Standard fit test procedures require the mixing of fit test compounds to specific fit testing composition required for threshold testing and subsequent fit testing. A device is needed for easy mixing of the components of the fit test composition and easy delivery of fit test composition during a fit test. For example, a device for fit testing of a gas mask on an individual wearer may include a sprayer, at least one ampoule containing a fit testing component, and a reservoir containing the ampoule and a solvent for the fit test component. The reservoir may be hollow body having a sealed inner volume. The reservoir may be deformable to break at least one hermetically sealed ampoule without tearing or otherwise breaking the reservoir. Therefore, the ampoule may be broken within the reservoir to mix the gas mask fit testing component into the solvent to generate the desired concentration for either a threshold test or gas mask fit test.

Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters.

The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.