The present invention provides an end fitting (1) for a spacer assembly and a spacer assembly having such an end fitting for fitting to a drug delivery inhaler device (21). The spacer assembly has a spacer body (17) with opposing first and second axial ends. The end fitting comprises an end panel having an upper end face (2) and a lower end face (3). A lower annular recess (4) is provided on the lower end face for receiving the first axial end (18) of the spacer body in a first configuration. An upper annular recess (12) is provided on the upper end face for receiving the second axial end (20) of the spacer body in a second configuration. The end fitting further comprises an open-ended tubular projection (16) extending from the upper end face and an aperture extending through the end panel from the lower end face to the tubular projection.

A drug delivery container and a nebulizer device are provided. The drug delivery container includes a body unit, a base unit, and an atomizing unit. The body unit includes a chamber element, the chamber element includes an accommodating space, an opening, and a through hole, and the accommodating space is communicated with both the opening and the through hole. The base unit includes a plurality of first conductive elements and is connected to the body unit. The atomizing unit includes a plurality of second conductive elements, and is located between the body unit and the base unit, and the second conductive elements respectively are electrically connected to the first conductive elements.

The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.

Methods and devices are provided for delivering one or more substances within at least one body cavity. Such devices include at least one nosepiece having at least one capsule including a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base having at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF, and at least one hollow puncturing member having at least one sharp end and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by at least one hollow tube. A fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with at least one end of the at least one puncturing member.

The disclosure relates to a fluid dispensing device including a housing, a mechanical biasing member, a closure, and a safety arrangement. The housing is configured to accommodate at least a portion of a spray delivery device and an outlet through which the fluid stored in the spray delivery device can be discharged. The mechanical biasing member is reversibly transferable between a pre-loaded state and an unloaded state and configured to store mechanical energy in the pre-loaded state effective to produce a spray discharge of the spray delivery device. The closure is fixable to the housing and movable relative to the housing between a closed position and an open position, wherein when in the open position the container of the spray delivery device is accessible from outside the housing. The movement of the closure is controlled by the safety arrangement.

A dry powder inhaler (1) has a chamber (12) for housing a capsule and an inhalation channel (22), the chamber (12) is shaped in order to determine an agitated motion of the capsule in the chamber (12) during an inhalation of a user, the inhaler (1) comprises a capsule-piercing mechanism (30) arranged to pierce a capsule in the chamber (12) and a monitoring system (40) comprising an accelerometer (42) arranged on a printed circuit board (48) in order to measure mechanical oscillations determined at least by the agitated motion and by a flow of air through the chamber (12) and/or inhalation channel (22); a detection unit (44) arranged to detect an activation of the capsule-piercing mechanism (30); and an electronic processing unit (46) configured to receive signals from the detection unit (44) and from the accelerometer (42). Reception of a signal from the detection unit (44) triggers processing of signals from the accelerometer (42) by the electronic processing unit (46) in order to generate inhalation data.

A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.

A cap for a nasal spray apparatus, the cap including a spray dispensing mechanism and further including a base sealingly mountable on a container of liquid substance to be dispensed; an intermediate section arranged for reciprocating movement relative to the base the intermediate section including the spray dispensing mechanism and having a spray dispensing passage; a cover-section having a depressible flexible portion, coupled to the intermediate-section; and a Light Emitting Diode (LED) connected to a power source through an electric circuit, the LED mounted adjacent the spray dispensing passage so as to be inserted into a nostril therewith; wherein the depressible flexible portion is arranged and configured to cause closure of the electric circuit for activating the LED and to actuate the spray dispensing mechanism, to provide both illumination and spray of liquid substance into the nostril.

A method of assembling a fluid dispenser device, the method comprising the following steps: pre-assembling a first unit comprising a body (10) and a lateral actuator system (40), said lateral actuator system including a presser element (42) that is mounted on the body (10) to pivot about an axis (A), an actuator element (41) being mounted on said presser element (42) to pivot about an axis (B), said presser element (42) having a pre-assembled position in which said lateral actuator system (40) is blocked; assembling a second unit, comprising a dispenser member (30), such as a pump or a valve, that is mounted on a reservoir (20) by means of a fastener ring (60), in said first pre-assembled unit; and moving said presser element (42) from its pre-assembled position to a final assembled position that is axially offset from said pre-assembled position, and in which said actuator element (41) co-operates operationally with said fastener ring (60) so as to actuate said dispenser member (30) each time the lateral actuator system is actuated.