A dry powder inhaler is provided. The inhaler is adapted for detachably mounting a compliance monitor having a pressure sensor. The inhaler has a housing comprising first and second shell parts, and a mouthpiece which defines an inhalation passage. An external surface of the housing has an orifice. A conduit from the orifice to the inhalation passage is formed by a channel in one of the shell parts and a corresponding channel cover in the other shell part. When the compliance monitor is mounted on the housing, the pressure sensor is adjacent to the orifice and is in fluid communication with the inhalation passage via the conduit.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

An assistance device for the use with a product dispensing device includes an engaging unit to the dispensing device, a locking unit for locking the dispensing device and configured to prevent or permit dispensing of the product, and a measurement unit for measuring a quantity of the product dispensed by the dispensing device. The locking unit remains unlocked for a predetermined period of time starting from a predetermined activation of the assistance device and then locks automatically at the end of the predetermined period. The locking unit locks automatically when a quantity of the product dispensed during the predetermined period reaches or exceeds a predetermined threshold.

An assistance device for a product dispensing device is provided, in which product dispensing is implemented by displacement or deformation of a moving part of the dispensing device between a rest position and an activation position. The assistance device includes an engaging unit, a locking unit configured to prevent the dispensing of the product, an actuator configured to switch the locking unit from a locked position to an unlocked position, a return unit configured to switch the locking unit from the unlocked position to the locked position, out of the activation position of the product dispensing, a blocking unit for blocking the locking unit in the unlocked position, a first disengagement member for disengaging the blocking unit configured to be triggered upon the activation of the dispensing device, and a second disengagement member for disengaging the blocking unit configured to be triggered independently of the activation of the dispensing device.

The present invention relates to an add-on device for a metered dose inhaler, an observance improvement system, and a method for improving observance of use in metered dose inhalers, the add-on device comprising an observance system housing component comprising an observance system with at least one pressure sensor; a mouthpiece component configured to fit, surround and removably engage with an exterior surface of a mouthpiece outlet provided on the metered dose inhaler; wherein said observance system housing is configured to fit and removably engage with said mouthpiece component; and said mouthpiece component is specifically adapted to conform to the exterior surface of the mouthpiece outlet of the metered dose inhaler without obstructing delivery of a dose of drug through said outlet.

A mist inhaler device (200) for generating a mist for inhalation by a user. The device comprises a mist generator device (201) and a driver device (202). The driver device (202) is configured to drive the mist generator device (201) at an optimum frequency to maximise the efficiency of mist generation by the mist generator device (201).

A system and method for measuring the effectiveness of a dose from an inhaler on a user is disclosed. The inhaler includes a drug container and a dosing mechanism coupled to the drug container to aerate a dose from the drug container. The dosing mechanism provides the aerated dose to the user. A sensor interface is in communication with a physiological sensor. The physiological sensor is attached to a user to sense a physiological response to the dose. Physiological data is sent to the sensor interface. A controller is coupled to the sensor interface to collect the sensed physiological data from the user corresponding to the time that the aerated dose is delivered to the user. The effectiveness of the dose may be determined from the collected data. The dose amount or frequency may be changed or the drug may be changed based on the collected data.

A refill assembly configured to be removably coupled to a reusable assembly of a medicinal inhaler is disclosed and includes a patient port, a canister actuable by the reusable assembly to deliver a dose of medicament to the patient port, and a sleeve which is selectively actuable by a user independently of the reusable assembly so as to act on the canister to deliver a dose of medicament. The refill assembly further includes an override element which engages the sleeve, the override element being moveable from a first position in which the sleeve is retained in a first position by the override element and a second position in which the sleeve is permitted to move to a second position upon depression of the sleeve by a user to cause a dose of medicament to be delivered to the patient port.

A dispenser for applying liquid, having a housing with an applicator opening and a liquid reservoir. The dispenser has a ventilation duct by which an ambient atmosphere is connected to the liquid reservoir so that, after the application of liquid, an inflow of air from the atmosphere is permitted into the liquid reservoir. The dispenser is provided with a detection installation which for detecting an application procedure detects air flowing in through the ventilation duct. The dispenser has a protective cap covering the applicator opening on the housing. The dispenser in the ventilation duct has a switch valve operable by activating a push-button on the external side of the housing. The protective cap acts on the push-button when placed on the housing or when the protective cap is being placed thereon to open the switch valve.

Provided is a fine particle generating apparatus outputting usage information, and in particular, a fine particle generating apparatus that generates fine particles through electrical heating and outputs usage information thereof to a user. Also, provided is a fine particle generating apparatus that generates fine particles by determining whether a puff has occurred according to a temperature variation amount per unit time. Also, provided is a fine particle generating apparatus or an aerosol generating apparatus capable of changing puff conditions by controlling a heater. Also, provided is a fine particle generating apparatus that generates fine particles through electrical heating.