An adherence-monitoring and tracking device captures usage of a metered dose inhaler (MDI). The device includes an enclosure for enclosing a metered dose inhaler (MDI), and an electro-mechanical system forming a part of enclosure to sense and log the operation of the MDI. The electro-mechanical system includes at-least one transducer to capture one or more parameters pertaining to an operation of the MDI by the user. A microcontroller processes the captured parameters, and an output-unit renders data pertaining to operation of the MDI.

An electronic inhaling device for detachably receiving a spray bottle having a bottle body with a spray mouth, includes: a casing formed with a vertical slide slot, in which the spray bottle is adapted to be disposed slidably; a bottle support seat installed in the casing, having a receiving inlet permitting extension of the spray mouth of the bottle body when the spray bottle is seated on the support seat and a discharging outlet in spatial communication with the receiving inlet in order to discharge a volatile substance sprayed out from the spray mouth of the bottle body via the discharging outlet; and a monitoring module disposed in the casing for monitoring movement of the spray mouth relative to the bottle body, counting a discharged number of the volatile substance sprayed out from the spray mouth of the bottle body via the discharging outlet.

The present invention provides a method for producing condensation aerosols for the treatment of disease and/or chronic, intermittent or acute conditions. These condensation aerosols are produced from drugs including temperature sensitive drugs and small molecule drugs that are coated onto a foil substrate which is heated via electrical resistance heating at precisely controlled temperature profiles with controllable ramp-up and heating rates to vaporize the coated drug which subsequently condenses to form aerosol particles. These condensation aerosols have little or no degradation products. Kits comprising a drug and a device for producing a condensation aerosol are also provided. Also disclosed, are methods for using these aerosols and kits and methods of making the aerosols.

A metered dose inhaler having a body for receiving a medicinal canister. A dome shaped motorized unit is attached to the main body of the inhaler. A lower mouthpiece end is in communication with an output valve of the canister for issuing an atomized medicinal spray. A plurality of apertures are defined along any of the sides or front and back walls of the body such that, upon depressing a trigger associated with the canister in combination with patient inhalation, the actuation of the motor combines results in more efficient delivery of the spray and to better direct the spray into the patient's respiratory system. A further variant incorporates a motorized cap, such as for use by handicapped individuals who may be unable to actuate the metered dose inhaler due to anatomical or physiological disabilities.

Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

A system for operating an inhalation device including an inhalation device that has been configured to store at least one substance and dispense the substance in a predetermined manner, wherein the inhalation device is configured to gather usage information from the inhalation device and transmit the gathered usage information to a location remote from the inhalation device and to receive operational commands from a location remote from the inhalation device; a controller in communication with the inhalation device, wherein the controller is configured to receive usage information from the inhalation device and to transmit operational commands to the inhalation device; and a remote server in communication with the controller, wherein the remote server is configured to receive queries from the controller, and transmit information relevant to the queries back to the controller.

A usage recording smart label and inhaler, and methods for detecting, verifying and recording actuation events of the inhaler, are disclosed. The usage recording smart label comprises a capacitive touch sensing plate to detect the presence of an activating body organ such as a hand or finger. The smart label, which may be in the form of a sticker or sticker-like, is attached to a grasping or actuation surface of the inhaler. The smart label may comprise text printed thereon, used as a replacement for an existing printed label. A usage recording method comprises (a) the usage recording smart label detecting an event of proximity of a finger for a given minimal time duration; (b) recording a timestamp of the event in memory of the smart label; (c) communicating stored timestamp data from the memory to an external device; the external device can be configured to display the actuation history.

Some embodiments are directed to an adherence monitor for use with a tethered cap inhaler device. The monitor engages the inhaler device, and includes a tether opening for receiving the tether, so that the path length of the tether around the monitor is minimized or reduced.

The present invention relates to an add-on device for a metered dose inhaler, an observance improvement system, and a method for improving observance of use in metered dose inhalers, the add-on device comprising an observance system housing component comprising an observance system with at least one pressure sensor; a mouthpiece component configured to fit, surround and removably engage with an exterior surface of a mouthpiece outlet provided on the metered dose inhaler; wherein said observance system housing is configured to fit and removably engage with said mouthpiece component; and said mouthpiece component is specifically adapted to conform to the exterior surface of the mouthpiece outlet of the metered dose inhaler without obstructing delivery of a dose of drug through said outlet.

An aerosol generation device includes: a load configured to heat an aerosol generation article by using power that is supplied from a power source, the aerosol generation article comprising an aerosol-forming substrate configured to hold or carry at least one of an aerosol source and a flavor source; and a control unit configured to control the power that is supplied from the power source to the load. When starting the supply of power to the load in a non-operation state, or when the load is in a preparation state in which the load is not capable of generating a predetermined amount or more of aerosols from the aerosol generation article, the control unit is configured to control the power that is supplied from the power source to the load by feed-forward control.