Product manifolds for use with portable oxygen concentrators and portable oxygen concentrators including such product manifolds. An example product manifold for use with a portable oxygen concentrator includes a body, a first product port, a second product port, an accumulator port, an output port, and a flow path. The flow path fluidly couples the first product port, the second product port, the accumulator port, and the output port. The product manifold includes a first control port, a second control port, and a third control port. The first, second, and third control ports fluidly couple the flow path. The product manifold also includes a first solenoid valve assembly, a second solenoid valve assembly, and a third solenoid valve assembly. The first, second, and third solenoid valve assemblies are secured to the body of the product manifold adjacent the first, second, and third control ports, respectively, by a corresponding snap fit connector.

A flow generator for generating a mixed oxygen air flow, the flow generator including a body having a first inlet, a second inlet, an outlet, and one or more inner surfaces that define a first inner chamber in fluid communication with the first inlet and the second inlet, a second inner chamber in fluid communication with the first inner chamber, and a third inner chamber in fluid communication with the second chamber and the outlet of the body. The flow generator includes a connector disposed in the first inlet and a nozzle disposed within at least a portion of the connector and extending into the first inner chamber. The flow generator further includes an adapter engaged to the nozzle to form a fluid tight path such that the adapter connects to an external oxygen source and transports oxygen into the nozzle.

A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO.sub.2 to check and calibrate NO and NO.sub.2 sensors.

A medical breathing gas delivery system design employs a manifold delivering gas in a controlled fashion to patients which includes two inhaled gas one-way valves, at least one pressure sensor for patient airway pressure monitoring, and one controlled exhalation pressure proportional control valve which may be overridden by patient exhaled pressure or if there is a power loss. The manifold is connected to a controlled source of breathing gas which may, for example, be a variable-speed fan, or a pressure-based gas flow controller with dynamic self-calibration employing a fast-acting valve and a pressure sensor, either of which yield predictable gas flow control with a minimum of components. The manifold exhalation pressure control valve and gas flow source may, for example, be controlled with a computer system which adjusts the valve power waveforms to attain the time-varying flow and pressure curves required by clinicians, then stores and displays the waveforms to enable long-term trend monitoring and alarm generation. Accurate gas mixing using the pressure-based gas flow control yields automatically calibrated mixes which are of use for patients in, for example, intensive care ventilation and in anesthesia machines for operating rooms.

A nasal respiratory mask for a high flow oxygen therapy apparatus, comprising: a mask frame; and a mask cushion on the mask frame for contacting and substantially sealing against a face of a patient, the mask frame and mask cushion defining a nasal breathing cavity, wherein the mask frame comprises: a hose attachment portion for attaching a hose for delivering a supply of oxygen enriched air to the patient; and a mask aperture for restricting the flow of gas from the nasal breathing cavity directly to ambient, wherein the mask aperture maintains a positive end-expiratory pressure (PEEP) in the nasal breathing cavity of between 0.2 kPa and 1 kPa during the administering of high flow oxygen therapy to the patient.

A system and process for the recovery of at least one anesthetic from a gas stream including at least two anesthetics. The recovery includes adsorption by exposing the gas stream to an adsorbent. The adsorbent is then regenerated by exposing the adsorbent to a purge gas under conditions which efficiently desorb the at least two anethetics from the adsorbent. The at least two anesthetics (and impurities or reaction products) are condensed from the purge gas and subjected to fractional distillation to provide a recovered anesthetic.

Ventilator system with multiple inspiratory lumens is provided. The inspiratory lumens are configured so that separate inspiratory lumens provide inspiratory gas mixtures to separate portions of a patient's airways, for instance to separate lungs and/or bronchi. The ventilator system can include one or more expiratory lumens to evacuate expiratory gases from airways. The use of separate inspiratory lumen(s), with expiratory lumen(s), allows for functional separation of structural portions of the lungs, and maintenance of continuous or almost continuous flow through at least part of respiratory cycle via inspiratory and expiratory lumens. This can further reduce dead space and clear suspended therein diseases causative agents with improvement in outcomes, reduce risk of cross-contamination or cross-infection between different parts of airways, for example such as cross-infection from one lung lobe to another lobe or. The ventilator system allows for independent titration of PEEP, pCO.sub.2 and pO.sub.2 with no need for permissive hypercapnia.

Provided are an anesthesia respiration apparatus, an anesthesia respiration gas path system, and an anesthetic gas path system, to exhibit a novel anesthesia respiration structure. In this structure, some channels are provided in an anesthesia main machine, and no long external pipeline or only a small number of long pipelines are required to meet demands of gas path connection, thereby reducing various potential safety hazards and inconvenience caused by excessive exposed long pipelines.

Breathable medical circuit components and materials and methods for forming these components incorporate breathable foamed materials that are permeable to water vapor and substantially impermeable to liquid water and the bulk flow of gases. The materials and methods can be incorporated into a variety of components, including tubes, Y-connectors, catheter mounts, and patient interfaces and are suitable for use in a variety of medical circuits, including insufflation, anesthesia, and breathing circuits.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.