A method of mass spectrometry is disclosed involving scanning a parameter of a first device through which a mixture of components is passed. Different components are transmitted through or produced in the first device at different values of the parameter and hence scanning the device parameter introduces a temporal modulation or profile to the components. This temporal variation is then removed prior to mass analyzing the components through a process of homogenization.

The driver condition detection system includes a driver monitor camera capturing a face of a driver of a vehicle and generating a facial image of the driver, and a driver condition detection part configured to detect a condition of the driver based on the facial image. If a part of face parts of the driver is hidden in the facial image, the driver condition detection part is configured to detect a condition of the driver based on face parts of the driver not hidden in the facial image. The face parts of the driver are a mouth, nose, right eye, and left eye of the driver.

The present invention provides an accelerator mass spectrometry device for simultaneously measuring isotopes. In one embodiment, the device comprises a sputtering negative ion source for generating negative ions; the sputtering negative ion source being connected to an accelerating tube for simultaneously accelerating a plurality of isotopic ions; an output end of the accelerating tube being connected to an isotope mass resolution system; the isotope mass resolution system being connected to a charge conversion analysis and multi-receiving measurement system; the charge conversion analysis and multi-receiving measurement system being connected to an ion detection system. The present invention is capable of accelerating a plurality of isotopic negative ions simultaneously. The accelerated isotopic negative ions are separated. Stable isotopic negative ions are measured by a stable isotope receiver. Unstable isotope negative ions are converted to positive ions and then measured by a detector.

The invention provides (a) a time-of-flight mass spectrometer with an acceleration region, a single-stage or multi-stage reflector, and an ion detector, further comprising an additional reflector whose potential has, at least in a subregion, a two-dimensional logarithmic potential component and a two-dimensional octopole potential component, and (b) methods for operating the time-of-flight mass spectrometer.

Disclosed herein is a method for evaluating and measuring the performance, efficacy and safety of candidate new chemical entities. This method comprises employing a target compound having one or more .sup.12C atoms in the molecule wherein at least one of the .sup.12C atoms is substituted with a .sup.13C atom, The stable labelled target compound is then administered to a test subject following which the target compound and/or one or more of its metabolites are recovered using conventional separation techniques and purified. The resulting isolated material of interest is then combusted in the presence of a petrochemical based carrier, the .sup.12C content of such carrier with respect to naturally occurring .sup.13C being in excess of 99.9 percent. The CO.sub.2 resulting from such combustion is then graphitized and the graphitized material is analyzed employing techniques, such as Accelerator Mass Spectrometry (AMS), capable of differentiating and counting the carbon atom isotopes (.sup.13C vs. .sup.12C), thus allowing quantification of the compound/metabolite of interest.

A method of treating a particle beam is disclosed, of interest in particular for mass spectrometry for .sup.14C. A particle beam including positive ions is passed through a charge exchange cell containing a target gas. The target gas is electrically insulating at room temperature and pressure. At least some of the positive ions of the particle beam are converted to negative ions by interaction with the target gas. The particle beam incident at the charge exchange cell includes molecules and/or molecular ions which interact with the target gas to reduce the concentration of molecules as a result of repeated collisions with particles of the target gas. A corresponding mass spectrometry system is also disclosed.

Optical spectrometer apparatus, systems, and methods for analysis of carbon-14 including a resonant optical cavity configured to accept a sample gas including carbon-14, an optical source configured to deliver optical radiation to the resonant optical cavity, an optical detector configured to detect optical radiation emitted from the resonant cavity and to provide a detector signal; and a processor configured to compute a carbon-14 concentration from the detector signal, wherein computing the carbon-14 concentration from the detector signal includes fitting a spectroscopic model to a measured spectrogram, wherein the spectroscopic model accounts for contributions from one or more interfering species that spectroscopically interfere with carbon-14.