A high-voltage (HV) power supply outputs an output voltage based on a control signal produced by a dual analog/digital feedback loop. The control signal is determined at least in part by an error amplifier that receives a measurement signal, proportionally attenuated from the output voltage, and a digital-to-analog converter (DAC) output signal. An analog-to-digital converter (ADC) also receives the measurement signal and transmits it in digitized form to a digital processor. The digital processor calculates a digital DAC data signal based on the measurement signal, and on a digital set-point input signal corresponding to a set-point voltage value of the output voltage desired to be outputted from the high-voltage source. A DAC receives the DAC data signal and converts it to the DAC output signal transmitted to the error amplifier.

Fluctuations of an output voltage at the time of a sudden change in a load current is suppressed while keeping an increase in size of a device. According to one aspect of the present invention, a high-voltage power supply device capable of outputting a high voltage of both positive and negative polarities in a switchable manner, includes: a first voltage generation unit (1A) configured to output a high voltage of a positive polarity; a second voltage generation unit (1B) configured to output a high voltage of a negative polarity; a first discharging diode (2A) connected to a voltage output end of the first voltage generation unit in a direction in which when a high voltage is outputted to the voltage output end of the first voltage generation unit, the high voltage is applied to the first discharging diode in a reverse biased state; a second discharging diode (2B) connected to a voltage output end of the second voltage generation unit in a direction in which when a high voltage is outputted to the voltage output end of the second generation unit, the high voltage is applied to the second discharge diode in a reverse biased state; a first output circuit connected between the voltage output end of the first voltage generation unit and a polarity switching voltage output end which is common to both the positive and negative polarities, the first output circuit being configured by a first switch (3A1) and a protective resistor (5A) connected in series to each other, the first switch being configured by a voltage-controlled semiconductor switch; a second output circuit connected between the voltage output end of the second voltage generation unit and the polarity switching voltage output end, the second output circuit being configured by a second switch (3B1) and a protective resistor (5A) connected in series to each other, the second switch being configured by a voltage-controlled semiconductor switch; an output capacitor (4) connected in parallel to a load (100) to be connected to the polarity switching voltage output end; a controller (7) configured to control operations of the first voltage generation unit and the second voltage generation unit and opening/closing operations of the first switch and the second switch such that both the first voltage generation unit and the second voltage generation unit are turned on once in a state in which both the operations of the first voltage generation unit and the second voltage generation unit are stopped when switching a polarity of a voltage outputted from the polarity switching voltage output end; a first limitation unit (<

A mass spectrometer includes a control system arranged to assess an operational state of the mass spectrometer. When a fault is detected, the control system assigns the fault to one of a plurality of categories, including a first category of faults which may be attempted to be rectified automatically by the mass spectrometer, a second category of faults which may be attempted to be rectified by the user, and a third category of faults which may only be attempted to be rectified by a service engineer. When a fault is assigned to the first category of faults, the control system initiates an attempt to automatically rectify the fault. When a fault is assigned to the second category of faults, the control system causes information relating to the fault to be displayed to the user, including data indicative of the fault and data one or more steps to be taken by the user to attempt to rectify the fault (2000). When a fault is assigned to the third category of faults, the control system causes information relating to the fault to be displayed to the user including data indicative of the fault, and an indication that the user should call a service engineer.

In one aspect, a curtain and orifice plate assembly for use in a mass spectrometry system is disclosed, which comprises a curtain plate including a first printed circuit board (PCB) having an aperture configured for receiving ions generated by an ion source of the mass spectrometry system and at least one gas-flow channel, where said first PCB has at least one metal coating disposed on at least a portion thereof. The assembly further includes an orifice plate coupled to the curtain plate, which includes a PCB providing an orifice that is substantially aligned with the aperture of the curtain plate so that the ions entering the assembly via said aperture of the curtain plate can exit the assembly via said orifice of the orifice plate, where the second PCB has at least one metal coating disposed on at least a portion thereof.

A mass spectrometer comprises an orifice plate having an orifice, a first multipole ion guide in a first chamber downstream of said orifice plate, said first multipole ion guide comprising a plurality of rods, and a second multipole ion guide in a second chamber downstream of said first chamber, said second multipole ion guide comprising a plurality of rods. A first ion lens is between the first and the second multipole ion guides. A third multipole ion guide is in a third chamber downstream of the second chamber, the third multipole ion guide comprises a plurality of rods. A second ion lens is between the second and third chambers. A tunable DC voltage source applies a tunable DC offset voltage to at least one of the above ion guide and ion lenses to increase an axial kinetic energy of the ions to cause at least one of declustering and/or fragmentation.

A mass spectrometry apparatus includes an ion detector and a control circuit coupled to the ion detector. The ion detector includes a pulse counting stage and an analog stage configured to generate a pulse counting signal and an analog signal, respectively, responsive to incident ions. The a control circuit is configured to output the pulse counting signal in a pulse counting output mode and to output the analog signal in an analog output mode. The control circuit is configured to switch from the pulse counting output mode to the analog output mode responsive to the pulse counting signal exceeding a first threshold within a range of about 10 million counts per second to about 200 million counts per second. Related devices and operating methods are also discussed.

A voltage stabilizer assembly includes a power supply, a device, and a voltage stabilizer. The device is connected to the power supply, wherein the device performance is affected based on the regulation of its power source. The voltage stabilizer is connected between the device and the power supply. The voltage stabilizer includes a low pass filter connected to an output of the power supply and a buffer receiving its input from the low pass filter, the buffer receiving power from the power supply, and the output of the buffer connected to the device.

A gas chromatograph mass spectrometer includes a separator that separates a sample, and a mass analyzer that performs mass spectrometry on the sample introduced from the separator, the mass analyzer includes a filament and an ionization chamber into which thermal electrons from the filament and the sample from the separator are introduced, and an opening through which the thermal electrons emitted from the filament pass and which is formed in the ionization chamber or in a member arranged between the ionization chamber and the filament has a maximum diameter of less than 3 mm.

A device of detecting a current from a sensor is disclosed. The device includes an integrating circuit including a network of capacitors for providing a gain setting and configured to convert the current to a voltage ramp over a length of integration time, the integrating circuit further including a reset switch configured to connect an input and an output of the network of capacitors; an ADC configured to digitize the voltage ramp into a plurality of voltage samples; and a set of modules including an analyzing module configured to analyze the plurality of voltage samples to determine a slope of the voltage ramp; an outputting module configured to determine a magnitude of the current based on the slope of the voltage ramp and the gain setting; and a reconfiguring module that is configured to reconfigure the network of capacitors and reset the voltage ramp via the reset switch.

An ion analyzer 2 including: a power feeding circuit 26 in which a power supply connection part 261, a first electrode connection part 262, a first resistance element 263, a second electrode connection part 264, a second resistance element 265, and a grounding part are provided in series; a power supply P connected to the power supply connection part 261 and configured to output both a DC positive voltage and a DC negative voltage; a first voltage supply electrode 23 connected to the first electrode connection part 262; and a second voltage supply electrode 24 connected to the second electrode connection part 264. In particular, it can be suitably used as a device for applying a voltage to a push electrode 23 and a convergence electrode 24 disposed in an ionization chamber 20 of a mass spectrometer including an ESI source 21.