A personal respiratory isolation system (PRIS) provides a personal, negative pressure environment for a patient or user that reduces contamination and spread of pathogens exhaled by the patient into the environment. The PRIS includes an enclosure to receive the patient's head (such as a hood and a drape) and a negative pressure source which draws ambient air into the interior of the enclosure and draws air within the enclosure's interior (including the exhalations of the patient, including any contaminants and/or pathogens) out of the enclosure via a fluid port into a container for biohazard processing or disposal. The PRIS may allow positive air pressure therapeutic treatments to be delivered to the patient within the negative pressure environment, and the PRIS may maintain a constant pressure within the interior of the enclosure. The PRIS may include a transparent, hinged face shield for ease of patient observation and/or access.

A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

A patient interface assembly includes a flexible cushion configured to sealingly engage the patient's nares and a frame with a pair of flexible extending members that extend laterally from opposite sides of the frame. The frame and the flexible cushion together form a chamber. The patient interface assembly also includes a positioning and stabilising structure configured to maintain the flexible cushion in engagement with the patient's nares. The positioning and stabilizing structure has a pair of headgear straps. Each headgear strap is connected to a respective one of the flexible extending members. The flexible extending members do not form an airflow path for the breathable gas. The headgear straps have a multi-layered structure, at least one layer being made of fabric and at least one layer being made of plastic. In addition, the at least one plastic layer is a rigidizer that adds rigidity to the respective headgear strap.

A patient interface assembly includes a flexible cushion configured to sealingly engage the patient's nares and a frame with a pair of flexible extending members that extend laterally from opposite sides of the frame. The frame and the flexible cushion together form a chamber. The patient interface assembly also includes a positioning and stabilising structure configured to maintain the flexible cushion in engagement with the patient's nares. The positioning and stabilizing structure has a pair of headgear straps. Each headgear strap is connected to a respective one of the flexible extending members. The flexible extending members do not form an airflow path for the breathable gas. The headgear straps have a multi-layered structure, at least one layer being made of fabric and at least one layer being made of plastic. In addition, the at least one plastic layer is a rigidizer that adds rigidity to the respective headgear strap.

For a nasal cannula system, a pair of clip systems may be used to secure the legs of tubing loops placed about a patient's ears, wherein the size of each tubing loop may be adjusted by sliding a clip system along the length of the legs of the tubing loop.

An oxygen concentrator may have a compressor to feed a feed gas for sieve bed(s) via a first manifold, an accumulator to receive enriched air from the bed(s) via a second manifold. It may include an outer housing for the manifolds, the compressor, and the accumulator. The housing may include an access portal to a compartment therein, for removably receiving the bed(s) as a canister assembly. The first manifold may be adjacent to the compartment and have inlet coupling(s) for removably coupling respectively with inlet(s) of the canister assembly. The inlet coupling(s) may each have a first central axis. The second manifold may be adjacent to the compartment and have outlet coupling(s) for removably coupling respectively with outlet(s) of the canister assembly. The outlet coupling(s) may each having a second central axis. The first and second central axes may form any one of an obtuse, acute, or right angle.

Embodiments of the present disclosure include a nasal pillow apparatus having a first nasal pillow, a second nasal pillow, and a connecting bar that connects the first nasal pillow to the second nasal pillow, the connecting bar being disposed below a bottom surface of the first nasal pillow and a bottom surface of the second nasal pillow. Each of the first nasal pillow and the second nasal pillow includes an inner wall having a first end and a second end opposite the first end; and an outer wall connected to the second end of the inner wall. When inserted into a nostril of a patient, the outer wall is configured to conform to the nostril by compressing in a first direction and expanding in a second direction.

The invention provides new systems/methods for providing oxygen to chronically ill patients, such as COPD patients, through a more efficient portable oxygen concentrator (“POC”) that at least sometimes delivers an enriched airflow having a significantly lower overall oxygen concentration than that administered by typical POCs. In aspects, the methods/systems of the present invention are configured to automatically switch from pulse delivery to continuous delivery, from continuous delivery to pulse delivery, or any combination thereof, at least once per day, when certain conditions occur. Methods/system can comprise the ability to switch between mode(s) comprising delivery of a moderately enriched oxygen airflow (MEOA) and mode(s) comprising delivery of intensively enriched oxygen airflow, highly enriched oxygen airflow, or both, and back again, based on one or more parameters.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

A method of method of high flow oxygen therapy (HFOT) and carbon dioxide (CO.sub.2) monitoring includes delivering high flow oxygen therapy (HFOT) via a central lumen of a nasal cannula, the nasal cannula comprising a proximal end, a distal end positioned within a pharynx region of a patient's airway, and the central lumen and a sampling lumen formed within a wall of the nasal cannula. The method also includes receiving sampled exhaled breath of the patient via the sampling lumen at a CO.sub.2 monitor, wherein the sampling lumen is configured to sample the exhaled breath at the pharynx region through the CO2-permeable membrane and direct the sampled exhaled breath to a CO.sub.2 monitor fluidly coupled to the sampling lumen and determining a level of CO.sub.2 in the exhaled breath using the CO.sub.2 monitor.