The present invention generally relates to systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement. At least some of these enhanced BCG flow measurements can be used to address some surprising phenomena that may, at times, occur when wild stream blending therapeutic gas into breathing gas that a patient receives from a breathing circuit affiliated with a ventilator. Utilizing at least some of these enhanced BCG flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives from a ventilator can at least be more accurate and/or over delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.

Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

The present disclosure pertains to a method and system configured for cough synchronization in a mechanical insufflation-exsufflation system. The system is configured to synchronize (712) the transition from an insufflation mode to an exsufflation mode to a patient initiated cough by detecting cough effort of the patient e.g. at the end of the insufflation phase. The detection of cough effort of the patient is based on one or more parameters associated with gas in the system. Upon detecting that the patient is initiating a cough, the system automatically switches the insufflation mode to the exsufflation mode to assist the patient to generate an effective cough.

A sensing arrangement for a medical device includes a housing having a rigid portion and a flexible portion, a collar of the flexible portion attached to an exterior of the rigid portion such that a stem of the rigid portion extends into an interior of the flexible portion. A sensing element is positioned at least partially within a passageway of the rigid portion, with at least one wire extending from the sensing element through the passageway and into the interior of the flexible portion. Front and rear flanges protrude from the flexible portion and are adapted to allow the sensing arrangement to be attached into an aperture in a wall of the medical device. The stem of the rigid portion may be positioned between the collar and front flanges of the flexible portion, such that the stem does not extend through the aperture of the wall of the medical device. There are also provided a seal, a removable component, a medical device and a system.

Embodiments disclosed herein are directed to ventilation devices, systems, and methods for applying positive end expiratory pressure (PEEP) to the lungs of a patient. For example, applying above atmospheric pressure to the lungs of the patient may mitigate alveolar collapse in the lungs and/or may have other health benefits for the patient.

A medical device measures a pressure of a pressurized breathing gas and includes a pressure sensor arranged at a point of measurement and measures the pressure of a sample gas at a sampling point. The sampling point and the point of measurement are connected by a pressure sampling tube in which a pressure wave of the sample gas can propagate from the sampling point to the point of measurement. The tube has a sampling tube volume and an acoustic impedance. The device further includes a damping arrangement fluidly communicating with the tube. The damping arrangement includes a flow restrictor and a receptor chamber arrangement. The receptor arrangement includes a receptor chamber which receives the pressure wave. The restrictor correlates to the acoustic impedance to prevent acoustic resonance in the tube. The receptor chamber correlates at least to the tube volume to prevent acoustic resonance in the tube.

Various methods and systems are provided for removing liquid from a sample containing both liquid component and gaseous component. In particular, the liquid component may be separated from the sample by flowing the gaseous component of the sample from a lower chamber to an upper chamber through a membrane. The liquid portion of the sample may be drain from the lower chamber via a drainage channel within the bottom wall of the lower chamber. The liquid portion of the sample flows horizontally outward in the drainage channel through capillary action induced by a capillary part positioned within the drainage channel.

The present disclosure provides systems and methods for nitric oxide (NO) generation and/or delivery. In some aspects, a nitric oxide generation system comprises a plasma chamber configured to ionize a reactant gas including nitrogen and oxygen to form a product gas that includes NO, a scrubber downstream from the plasma chamber and having a volume at least partially containing NO.sub.2 scrubbing material, and a flow controller downstream of the scrubber configured to control the flow of product gas from the scrubber to a delivery device. A pump is configured to convey product gas from the plasma chamber into the scrubber and is configured to pressurize the product gas in the scrubber when the flow controller is positioned to restrict the flow of product gas from the scrubber. The pressurized product gas accumulates within the scrubber and is at least partially scrubbed of NO.sub.2 prior to passage through the flow controller.