Systems and methods for producing nitric oxide (NO) to be used in medical applications are provided. In some embodiments, systems and methods are provided for a NO generator that is capable of generating a desired concentration of NO to be provided to a respiratory system for inhalation by a patient.

An apparatus for humidification of air to be delivered to a patient's airways may include a reservoir, and a humidifier chamber. The humidifier chamber may include a humidifier wick and a heating element for heating the humidifier chamber. The humidifier wick may comprise a fibrous sheet material. The humidifier chamber and wick may be vertically oriented in use such that a first end of the wick is above the second end of the wick. A deioniser may be provided to deionise the liquid prior to the humidifier wick. The apparatus may pasteurise liquid to be delivered to the humidification wick.

A personal respiratory isolation system (PRIS) provides a personal, negative pressure environment for a patient or user that reduces contamination and spread of pathogens exhaled by the patient into the environment. The PRIS includes an enclosure to receive the patient's head (such as a hood and a drape) and a negative pressure source which draws ambient air into the interior of the enclosure and draws air within the enclosure's interior (including the exhalations of the patient, including any contaminants and/or pathogens) out of the enclosure via a fluid port into a container for biohazard processing or disposal. The PRIS may allow positive air pressure therapeutic treatments to be delivered to the patient within the negative pressure environment, and the PRIS may maintain a constant pressure within the interior of the enclosure. The PRIS may include a transparent, hinged face shield for ease of patient observation and/or access.

An apparatus is provided to change the absolute humidity of a flow of air for delivery to an entrance of the airways of a patient, the change being compared to the absolute humidity of ambient air. The apparatus has a reservoir configured to hold a volume of liquid. A heating element creates vapour from the liquid. A chamber is provided to mix the flow of air with the vapour. The apparatus has a body having a first wall structure with a chamber inlet port. A closure element having an air inlet port for pneumatically connecting to a source of the flow of air is secured to the body to provide a sealed gas flow path between the air inlet port and the chamber inlet port, and a liquid trap in the gas flow path.

A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

A respiratory delivery system providing a bi-level pressure airflow. The system includes respiratory and pneumatic circuits. The respiratory circuit includes a respiratory gas supply, a patient interface, and a bi-level pressure regulator. The respiratory gas supply supplies a respiratory gas to the patient interface via a first conduit. The bi-level pressure regulator is coupled to the patient interface via a second conduit and is configured to cyclically alternate the respiratory gas passing through the bi-level pressure regulator between a low-pressure level and a high-pressure level. The pneumatic circuit includes a pneumatic gas supply and a pneumatic cycler configured to output a cycling pressure level. The cycler is coupled to the bi-level pressure regulator via a third conduit. The bi-level pressure regulator cyclically alternates the pressure level of the respiratory gas between the low-pressure level and the high-pressure level with the timing defined by the cycling of the pneumatic gas.

A method for determining that a patient interface component comprising a vent has been replaced between therapy sessions of treatment of sleep disordered breathing, the method comprising: acquiring or receiving first vent flow rate data representing one or more estimated first vent flow rates of gas through a first vent of a patient interface in use during a first therapy session; acquiring or receiving second vent flow rate data representing one or more estimated second vent flow rates of gas through a second vent of a patient interface in use during a second therapy session after the first therapy session; and identifying, by comparison of the second vent flow rate data to the first vent flow rate data, a difference in resistance to flow through the first vent than through the second vent indicating that the second vent is not the same vent as the first vent.

A head encapsulation unit is disclosed which filters virus contaminated air. The head encapsulation unit does not require a fitting process since the primary interface between the head encapsulation unit and the user is the user's neck. The head encapsulation unit has an expandable seal that a user can insert his or her head. The seal is then wrapped around and places light pressure against the person's neck so that virus contaminated air that does not enter the inner volume of the head encapsulation unit and infect the user. A cap at the upper portion of the unit and the seal aligns the head encapsulation unit on the user's head. This head encapsulation unit allows for both medical personnel and infected individuals to better and more easily communicate than mouth covered filters, goggles and face shield while offering substantially more mitigation from spreading an infection or being infected.

An apparatus for humidifying a flow of breathable gas includes a water reservoir and a water reservoir dock forming a cavity structured and arranged to receive the water reservoir in an operative position. The water reservoir comprises a reservoir base including a cavity structured to hold a volume of water, the reservoir base including a main body and a thermally conductive portion provided to the main body. The thermally conductive portion comprises a combined layered arrangement including a metal plate and a thin film, the thin film comprising a non-metallic material and including a wall thickness of less than about 1 mm. The thin film is adapted to form at least a bottom interior surface of the water reservoir exposed to the volume of water, and the metal plate is adapted to form a bottom exterior surface of the water reservoir.

An oxygen concentrator may have a compressor to feed a feed gas for sieve bed(s) via a first manifold, an accumulator to receive enriched air from the bed(s) via a second manifold. It may include an outer housing for the manifolds, the compressor, and the accumulator. The housing may include an access portal to a compartment therein, for removably receiving the bed(s) as a canister assembly. The first manifold may be adjacent to the compartment and have inlet coupling(s) for removably coupling respectively with inlet(s) of the canister assembly. The inlet coupling(s) may each have a first central axis. The second manifold may be adjacent to the compartment and have outlet coupling(s) for removably coupling respectively with outlet(s) of the canister assembly. The outlet coupling(s) may each having a second central axis. The first and second central axes may form any one of an obtuse, acute, or right angle.