The present disclosure relates to medicine delivery devices, as well as methods of delivering an aerosol medicine to a subject in need thereof. A benefit to the medicine delivery devices and methods herein can be the efficient delivery of an aerosol medicine to a subject in need thereof, thus helping to improve treatment outcomes, as well as avoiding wastage of expensive medicines. Additional benefits to the medicine delivery devices disclosed herein can be low cost, lightweight, compact, versatile, and simple to use devices useful for a wide range of patients and healthcare settings. Another benefit of the medicine delivery devices can be safer to use devices that can lower the risk of infection for patients and healthcare providers.

The present invention relates to an adapter for non-invasive mechanical ventilation probes with an inhalation port and orifice occluder. Specifically, the invention comprises a probe adapter with an inhalation port and orifice occluder, coupled to the oronasal mask disposed on a user or patient. According to the present invention, the probe adapter also receives a metered dose inhaler that further receives an anesthetic circuit with two enteral probes, a left enteral probe and a right enteral probe. The technical field of the invention belongs to the field of medical devices for respiratory therapy, for use in patients with assisted non-invasive mechanical ventilation and concomitant use of enteral probes with the requirement of metered dosage inhaled medicinal products.

The invention provides compositions, kits and methods for depositing a composition comprising a plurality of magnetic particles, to a target site of a subject by delivering the composition via controlled inhalation to a region of the subject's respiratory tract and applying a magnetic field to a target site within the region of the subject's respiratory tract to capture the particles in said target site.

A ventilator circuit apparatus is provided for the administration of an aerosolized drug from a nebulizer through an endotracheal tube to a patient on a mechanical ventilator with humidification of the breathing gases. Means to disconnect the nebulizer without interrupting the airflow to the patient is provided, with a T-fitting and three-way valve in the ventilator circuit that permits the nebulizer to be bypassed by the airflow, allowing the nebulizer to be removed from the apparatus without interrupting the flow of breathing gases to the patient. In embodiment, the nebulizer is breath-enhanced jet nebulizer. In an embodiment, the jet nebulizer is breath-actuated, by the use of an air pressure sensor that toggles the flow of pressurized air to the nebulizer that drives the jet required for nebulization.

A humidification apparatus includes a bag-shaped flexible reservoir where water is stored, a vaporizer that vaporizes supplied water, a water supply path connected to the flexible reservoir and the vaporizer, an accommodation portion where the flexible reservoir is accommodated, a pressurization source that compresses the flexible reservoir by pressurizing a space outside the flexible reservoir and inside the accommodation portion, and a controller that controls an operation of the pressurization source. Water stored in the flexible reservoir is supplied to the vaporizer through the water supply path by compressive force with which the flexible reservoir is compressed.

Manual resuscitators, ventilation control assemblies, and methods suitable for delivering a volume-controlled tidal volume of air to a patient's lungs. Such a resuscitator has a piston that pushes a selected volume of air out of a ventilation chamber of a cylinder in response to pressurized gases being introduced into an actuation chamber of the cylinder. A volume adjuster adjusts the maximum tidal volume of patient air that the piston pushes out of the ventilation chamber by adjusting the maximum length of the piston stroke in the cylinder. The volume adjuster may have a bypass mode that allows the manual resuscitator to operate without volume control. The manual adjuster may also be pressure regulated by one or more pressure regulation valves.

A nebulizer device aerosolizes (or vaporizes) liquid drawn from a liquid reservoir via a fluid flow path into a nebulization chamber. An inlet port is coupled to an external air supply and leads through a check valve and Venturi nozzle (e.g. a duckbill valve) into the chamber to direct an air stream across an opening of the fluid flow path. A discharge port leads from the chamber to a user mask, mouthpiece or canula, where the aerosol or vapor mixture can be inhaled. A filtered outlet port isolates exhaled material from the external environment. Multiple discrete heating elements may be placed around the fluid flow path to preheat the liquid. If the liquid is sufficiently volatile, heating may vaporize the material which can condense back into an aerosol after mixing with the air stream. A set of check valves direct one-way fluid flow and prevent leakage or spillage of material from the device.

A humidification device (200A) includes a reservoir (216), a vaporizer (250), a water supply passage (230), a gas introduction passage (240), a gas introduction source (260), and a controller. The reservoir (216) stores water. The vaporizer (250) vaporizes the water supplied to the vaporizer (250). The water supply passage (230) is connected to the reservoir (216) and the vaporizer (250) and filled with the water flowing from the reservoir (216). The gas introduction passage (240) is connected to an intermediate position of the water supply passage (230). The gas introduction source (260) introduces gas into the water supply passage (230) through the gas introduction passage (240) so as to push out, by using pressure of the introduced gas, toward the vaporizer (250) the water with which the water supply passage (230) is filled. The controller controls operation of the gas introduction source (260).

Disclosed is an anesthetic evaporator, comprising a housing, a drug reservoir, and a cover movably connected to the housing, wherein the drug reservoir is provided with a drug adding barrel arranged corresponding to the cover, and further comprising a mechanical pressure relief assembly and a linkage mechanism, wherein the mechanical pressure relief assembly is connected to the drug reservoir; the mechanical pressure relief assembly has a first state in which the pressure within the drug reservoir is maintained and a second state in which the pressure within the drug reservoir is released; when adding a drug, the operation action on the anesthetic evaporator drives the linkage mechanism, and the linkage mechanism drives the mechanical pressure relief assembly to switch same from the first state to the second state. The pressure of the anesthetic evaporator can be mechanically released, so that greater and reliability are realized.

A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.