Atomizer for a ventilation machine with a ventilator, including a body with a first connection for connecting the atomizer to a ventilator and a second connection for connecting the atomizer to a line leading to a patient, wherein the body forms a flow channel from the first connection to the second connection; and an atomizing device for atomizing a fluid; wherein the atomizing device is disposed between the first connection and the second connection in the flow channel and adapted so that the fluid can be atomized substantially parallel to, and preferably in, the flow direction from the first connection to the second connection.

An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

The invention relates to a device (10) for providing an aerosol from an aerosolizable material, the device comprising an aerosolization unit (300) through which pressure pulses of a carrier gas (60) are passed; a reservoir (100) comprising the aerosolizable material and which provides the aerosolizable material to the aerosolization unit (300) where the aerosolizable material is entrained by the carrier gas (60); a material providing valve (210) located between the reservoir (100) and the aerosolization unit (300) which opens in direction of the aerosolization unit (300) and which is opened and closed by a pressure difference between the reservoir (100) and the aerosolization unit (300) and which provides, in an open state, the aerosolizable material to the aerosolization unit (300).

A breath-enhanced nebulizer adapted for use in administering an aerosolized pharmaceutical composition to a patient by inhalation wherein the patient is connected to a mechanical ventilator is disclosed. The nebulizer has a Venturi driven by a nebulizer air supply that draws a solution of a pharmaceutical composition into a shear zone where the solution is atomized. The Venturi effect is amplified by the internal configuration of the nebulizer to increase the rate of nebulization of drug. Optionally, breath-actuated nebulization is used, employing a pressure sensor interposed between the nebulizer and mechanical ventilator that controls the nebulizer air supply, such that nebulizer air and concomitant nebulization only occurs during the inhalation phase of a breathing cycle.

A respiration moistener (1) has an inlet (3), into which incoming gas (2) to be moistened can be fed. Vapor (21) is mixed with the incoming gas (2) in a mixing chamber (4). Moistened outgoing gas (5) flows out of an outlet (6). In cases in which the temperature of the incoming gas (2) becomes so high that the temperature of the outgoing gas (5) is above a desired value, the internal desired value is adjusted. The outgoing gas (5) can then cool to the desired value on its way through the inspiration tube (7).

A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula or a face mask. An aerosol generator is mounted to the housing and delivers aerosol into an oxygen stream flowing between an inlet and an outlet of the housing. The housing also has a removable plug in the base thereof for draining any liquid that accumulates in the housing. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

A liquid reservoir (100) of a nebulizer has a funnel portion (102) with ribs (103, 104) extending downwardly along a side wall towards a reservoir outlet (105). The ribs (103, 104) prevent the formation of air bubbles between the aperture plate and medication as any trapped air will be expelled along the geometry formed by the rib or groove and reservoir wall. Bubble formation is therefore prevented with only modification of the wall internal surface configuration of the reservoir.

A humidification device (200A) includes a reservoir (216), a vaporizer (250), a water supply passage (230), a gas introduction passage (240), a gas introduction source (260), and a controller. The reservoir (216) stores water. The vaporizer (250) vaporizes the water supplied to the vaporizer (250). The water supply passage (230) is connected to the reservoir (216) and the vaporizer (250) and filled with the water flowing from the reservoir (216). The gas introduction passage (240) is connected to an intermediate position of the water supply passage (230). The gas introduction source (260) introduces gas into the water supply passage (230) through the gas introduction passage (240) so as to push out, by using pressure of the introduced gas, toward the vaporizer (250) the water with which the water supply passage (230) is filled. The controller controls operation of the gas introduction source (260).

A humidification apparatus includes a bag-shaped flexible reservoir where water is stored, a vaporizer that vaporizes supplied water, a water supply path connected to the flexible reservoir and the vaporizer, an accommodation portion where the flexible reservoir is accommodated, a pressurization source that compresses the flexible reservoir by pressurizing a space outside the flexible reservoir and inside the accommodation portion, and a controller that controls an operation of the pressurization source. Water stored in the flexible reservoir is supplied to the vaporizer through the water supply path by compressive force with which the flexible reservoir is compressed.

An adaptor for a respiratory assistance system delivers aerosols to a patient. The adaptor is lightweight with a small footprint to increase patient comfort. The adaptor has a nozzle and a sealing mechanism to maintain pressure therein regardless of whether the nozzle is inserted into the adaptor. The adaptor is configured to connect to medical tubing and a medicament delivery device.