An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen. The telescoping system can be capable of reversibly transitioning between navigation and thrombectomy modes by differentially disposing and actuating the components and enable faster, more efficient and simpler removal of thromboembolic material.

Disclosed is a multi-lumen catheter having a distal end catheter tip configured to improve fluid flow into and out from the catheter tip while reducing undesired recirculation during hemodialysis treatment of a patient. A first lumen and a second lumen each extends from the catheter proximal end to the catheter distal end, the first lumen and the second lumen being parallel to each other. A septum having a first side and a second side separates the first lumen from the second lumen. Some embodiments of the catheter tip include a beveled shape region, having a first lumen orifice, a second lumen orifice, and a septum top surface. Within the beveled shape region, at least a portion of the septum first side and at least a portion of the septum top surface form a first eave over the first lumen and at least a portion of the septum second side and at least a portion of the septum top surface form a second eave over the second lumen.

A vortex catheter thrombolytic system comprises an ultrasonic transducer; and a probe for transmitting a vortex acoustic field as well as a catheter, wherein the catheter is arranged in the probe for transmitting the vortex acoustic field, is connected to the ultrasonic transducer and is provided with a first inner channel and a second inner channel, the first inner channel is used for delivering drugs, and the second inner channel is used for vortex driving. A thrombolytic method comprises: performing an ultrasonic execution step through the vortex catheter thrombolytic system so as to generate an acoustic vortex; executing a focusing step so as to focus a drug delivery carrier to the center of the acoustic vortex; and executing a manipulation step so as to manipulate the drug delivery carrier to a lesion area.

In one aspect, the present disclosure provides a catheter, the catheter with a distal length extending to a distal end, the distal length configured to indwell a cavity of a patient body. The distal length may include a first lumen extending longitudinally through a lengthwise portion of the distal length, where the first lumen may be at least partially defined by a first inner diameter surface of the distal length. The distal length may include a second lumen extending longitudinally through the lengthwise portion of the distal length, where the second lumen may be at least partially defined by a second inner diameter surface of the distal length. A first fenestration may be disposed through a side wall of the first lumen. A proximal length of the catheter may include a proximal lengthwise portion of the first lumen and the second lumen.

In the present disclosure, embodiments of dual-stage syringes are disclosed along with delivery systems incorporating the dual-stage syringes. Embodiments of the dual-stage syringes described herein include sleeved dual-stage syringes, turn-key dual-stage syringes and dual-stage syringes including one or more one-way valves.

In the present disclosure, embodiments of microbead containment systems and containment methods are disclosed. The microbead containment system may include a microsphere container, which includes walls that define a containment space in the microsphere container, and microspheres within the containment space. The walls may include at least one magnetic component configured to produce a magnetic field within the containment space. The microspheres may include a diamagnetic material. The method of containing radioactive microspheres may include loading a plurality of microspheres comprising a diamagnetic material in a container comprising one or more magnetic components. The microspheres contained in the microsphere container interact with the magnetic field in a manner that prevents direct contact of the microspheres and the microsphere container.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

In the present disclosure, embodiments of flaring tip microcatheters, methods of deploying flaring tip microcatheters, and embolization treatment methods are disclosed. The flaring tip microcatheter may include a hollow shaft having a shaft lumen defined therein, a core disposed within the shaft lumen, and a tip comprising at least two petals affixed to a distal end of the core, the at least two petals comprising at least two wires wherein the core is hollow and defines a core lumen. The at least two wires may be configured to pull the at least two petals to form a flared configuration of the tip. The flared configuration of the tip may allow for laminar flow of a therapeutic agent distally from the tip.

A method and apparatus to direct a drug directly at the point needed for a specific duration for dialysis catheters which are made in standard sizes. Disclosed is a combination of a rate and duration-controlled infusion pump and reservoir and a pre-measured infusion catheter with a radiopaque distal tip. Along the length of the infusion catheter there is a luer lock connector and anti-leak valve. The invention is inserted into a dialysis catheter where the preset marking is aligned with the catheter hub and the distal infusion tip rest at or near the end of the dialysis catheter. The infusion unit is then activated, and the drug is delivered at the distal tip of the catheter, at or in the fibrin for maximum effect. The method of use and device saves time and resources as it can be deployed without the need for a surgical suite or heath care team.

Disclosed herein is a catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the catheter having a distal tube and a proximal shaft coupled to a proximal portion of the distal tubular member. The distal tube can have a tubular wall, a tube lumen defined within the tube by the tubular wall, a proximal opening sized to allow a medical device to be positioned therethrough, and at least one opening defined within the tubular wall along a length of the distal tube.