A catheter assembly for regulation or transfer of fluids to and from a patient. The catheter assembly may include a catheter and a valve assembly. The valve assembly may include a diaphragm having two unidirectional slit valves that open in different directions, a first unidirectional slit valve opening distally in response to an infusion-induced pressure and a second unidirectional slit valve opening proximally in response to an aspiration-induced pressure.

The invention relates to a cannula comprising a tip and an outlet, the cannula having a reduction in the internal diameter, which reduction is designed as a conically tapering tip the end of which has a length that is shorter than the internal diameter of the adjoining portion of the cannula.

An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

The present invention is directed to systems, devices and methods for trans-septally delivering carbon dioxide through a minimally invasive catheter to create a gaseous pocket or emphysema between the posterior wall of the left atrium and the esophagus during cardiac ablation of the left atrium. This pocket of gas expanded tissue serves to thermally insulate and separate the esophagus from the left atrium during ablation to prevent the formation of an atrial-esophageal fistula. The system comprises a control system to precisely deliver the gas to a desired location through a needle-based catheter assembly.

Provided are a catheter device and a catheter package which are capable of preventing a bend from being formed in a catheter body.

The catheter body includes a wire state discrimination portion which discriminates a protruding state and a non-protruding state, in which the wire state discrimination portion includes a stopper which allows a transition from the protruding state to the non-protruding state, and blocks a transition from the non-protruding state to the protruding state.

The present invention is directed to systems, devices and methods for trans-septally delivering carbon dioxide through a minimally invasive catheter to create a gaseous pocket or emphysema between the posterior wall of the left atrium and the esophagus during cardiac ablation of the left atrium. This pocket of gas expanded tissue serves to thermally insulate and separate the esophagus from the left atrium during ablation to prevent the formation of an atrial-esophageal fistula. The system comprises a control system to precisely deliver the gas to a desired location through a needle-based catheter assembly.

Intravascular devices and methods for intramural delivery of dissection fluids and infusates are disclosed herein. In some embodiments, the systems include an infusion assembly that can access a vessel wall at a depth within a layer of the vessel wall and advance a tissue manipulation component at approximately the same depth within the vessel wall to create an intramural space within the vessel layer. The infusion assembly can further deliver an infusate that includes a therapeutic drug or other agent into the intramural space.

A catheter for measuring a fractional flow reserve includes a proximal shaft, a distal shaft coupled to the proximal shaft, a pressure sensor coupled to the distal shaft, and at least one pressure sensor wire operably connected to the pressure sensor. The proximal shaft includes a radially expanded configuration and a radially collapsed configuration, wherein the proximal shaft has a first outer diameter in the radially expanded configuration and a second outer diameter smaller than the first outer diameter in the radially collapsed configuration. The distal shaft defines a guidewire lumen configured to receive a guidewire therein.

A base is configured to support a hemostasis valve having a driven surface configured to be rotatably driven to rotate a catheter secured thereto. The base may include a drive mechanism and a sideloading hemostasis valve holder configured to retain the driven surface of the hemostasis valve in engagement with the drive mechanism.

The present invention relates to a catheter 10. The catheter 10 includes a catheter tube 12 having a tip end 13 and a distal end 14, with the distal end 14 being coupled to or forming at least part of a funnel 16 for discharging fluid from within the catheter tube 12. A sleeve 18 is provided about the catheter tube 12 which is coupled at an end thereof to the funnel 16 and extends towards the tip end 13 of the catheter tube 12. The catheter 10 additionally includes a wetting mechanism 20 which is integrally formed with the funnel 16 and includes a holding chamber 22 and a fluid outlet 26 operable to allow fluid 24 from within the holding chamber 22 to be released within the sleeve 18 for wetting an outer surface of the catheter tube 12.