Devices and methods are described for injecting therapeutics into tissue. For example, some embodiments disclosed in this document describe devices and methods for injecting muscle precursor cells into the sphincter urethrae to treat stress urinary incontinence.

Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Delivery devices, systems, and methods are configured to enhance retention of a therapeutic agent delivered at a treatment site, for example, via impeding agent backflow. A device may include sheath having a first end, a second end, and a length between the first end and the second end. The sheath may include an outer diameter and an inner channel between the first end and the second end, and at least one penetrating member configured to form a channel at the treatment site. The device may include an elongate member having a first end, a second end, and a length between the first end and the second end, the elongate member being configured to move relative to the sheath. The elongate member may be configured to control the movement of the penetrating member with respect to the sheath.

A wall (39) of a catheter (38) (a) includes a braided portion (41) having an outer surface (45), an inner surface (47), and a braided interior (53) between the outer and inner surfaces (45, 47), and (b) is shaped to define first and second longitudinally-running channels (27a, 27b) therethrough. A distal portion of the catheter (38) is shaped to define first and second lateral openings (26a, 26b). An angle between (a) a first line (76) running between the first and second lateral openings (26a, 26b), and (b) a second line (78) that is parallel to a central longitudinal axis of the catheter (38) when the catheter (38) is straight, is between 30 and 150 degrees. A flexible longitudinal member (14) passes from a proximal portion of the catheter (38) to the distal portion via the first channel (27a), out of the first channel (27a) via the first lateral opening (26a), into the second channel (27b) via the second lateral opening (26b), and from the distal portion to the proximal portion via the second channel (27b).

The present invention relates to a stopcock for use in intravenous catheter apparatus and infusions of intravenous fluid to a patient. An intravenous catheter apparatus (10) comprising: an integrated three-way stopcock assembly (12), and a catheter hub assembly (14) having a proximal end (30a) configured to be connected to a needle hub (28) having a needle (18), and having a distal end (32a) configured to be connected to a catheter tube (16), wherein a straight needle (18) is capable of passing through said proximal end (30a) and distal end (32a) of the catheter hub assembly (14), in a ready position of the intravenous catheter apparatus (10), said catheter hub assembly (14) includes: a wing housing (36) at the distal end (32a), a housing (38) at the proximal end (30a), and a body portion (40) in between housing said three-way stopcock assembly (12); wherein said body portion (40) comprises an entry port (44) in communication with said housing (38), an exit port (46) in communication with said wing housing (36), wherein the entry port (44) and the exit port (46) extend along a horizontal line in an axial direction (A), and an injection port (48), wherein all of these ports (44, 46, 48) are confluent at a central chamber (50) configured within the body portion (40); wherein said three-way stopcock assembly (12) has a top portion (52a) and an opposing bottom portion (54a), both along a vertical line perpendicular to the horizontal line, as well as a handle (56) configured in said top portion (52a), wherein the handle (56) has a first portion (58) parallel to the horizontal line and a second portion (60) parallel to the injection port (48), in the ready position, and wherein the three-way stopcock assembly (12) has rotation capabilities relative to the body portion (40) of the catheter hub assembly (14).

Injection device comprising an elongated body (1) with a hollow needle (8) at a distal end; a reservoir for an injection material to be delivered through the needle; a plunger (3) with a first force element (5) configured to provide an injection force to said injection material, and a distal element (10) attached to the distal end of the device thereby sealing a needle lumen, wherein the distal element comprises a tissue interface and a distal seal (11), and wherein the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device, wherein the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue, wherein the penetrated distal seal opens a path for flow or delivery of the injection material from the distal end of the needle.

An electrosurgical device capable of both: (i) generating a radiative microwave field to perform either blood coagulation or sterilization, and (ii) dispensing a liquid to a target area, e.g. adrenaline for the treatment of peptic ulcers. Using microwave energy allows controlled coagulation which is unaffected by changes in tissue impedance during coagulation, and which can achieve a high level of coagulation within a given time. The electrosurgical device comprises a probe tip having a coaxial transmission line that includes a hollow inner conductor having a dielectric material formed on an inner surface thereof. A liquid-conveying channel is located inside the dielectric material. The probe tip includes a conductive element coupled to receive microwave energy from the coaxial transmission line, the conductive element forming a radiating antenna structure for emitting a microwave EM field outwardly from the probe tip.

A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.

Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula.