Catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially in the reduction of contrast-induced acute kidney injury. The catheter devices, systems and associated methods may prevent contrast dyes from entering into the kidney and/or facilitate blood flow beyond the kidney by utilization of the catheter devices, systems and associated methods.

A balloon catheter includes a shaft, a balloon made of an expandable membrane, a flexible substrate, one or more electrodes, and one or more radiopaque flags. The shaft is configured for insertion into a heart of a patient. The balloon is fitted at a distal end of the shaft. The flexible substrate is disposed on the membrane. The one or more electrodes are disposed over the flexible substrate and have a fishbone configuration. The one or more radiopaque flags are coupled to the expandable membrane, wherein the one or more radiopaque flags include a serpentine pattern so that the radiopaque flags fold in conformance with flexible substrate as the balloon is collapsed into a compressed or folded configuration.

Methods and compositions for treatments associated with endovascular grafts, dissections, peripheral aneurysms, and neuro aneurysms are provided that deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof and/or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

A method of fabricating a balloon catheter configuration is provided, the method comprises: preparing one catheter body, the catheter body comprises one internal tube, one external tube, and one stripping agent; the internal tube comprises one longitudinal groove and one drain passageway, wherein the longitudinal groove is configured in the exterior surface of the internal tube, the drain passageway is configured inside the internal tube, the external tube covers the internal tube, and the stripping agent is configured between the internal tube and the external tube; removing the internal tube of the catheter to allow one end of the external tube of the catheter body beyond one end of the internal tube adjacent to the external tube; folding the end of the external tube toward the axial center of the catheter; and attaching the end of the external tube to one part of the inner wall of the drain passageway.

An apparatus includes a catheter having a balloon including at least one first radiopaque marking. A guidewire guides the balloon to the treatment area, and includes at least one second radiopaque marking adapted for corresponding to the at least one first radiopaque marking of the balloon when positioned at the treatment area. Related aspects and methods are disclosed.

An airway management device comprising a body having a proximal end for receiving an oxygen supply tube and an distal end for insertion into a trachea of a patient; said body including a linear portion adjacent to the proximal end and a curved portion adjacent to the distal end; said body including an external shell and having a first bore through said shell for receiving the oxygen supply tube; wherein flexural strength for said airway management device is provided by said shell.

A clot capture catheter having an outer inflatable expansile member and an inner inflatable expansile member positioned within the outer inflatable expansile member at a distal end of a shaft of the catheter is presented herein. The inner and outer inflatable expansile members can have differing compliance than each other. Inflation of a higher compliance inner inflatable expansile member can cause a lower compliance outer inflatable expansile member to shorten and provide tension to the distal end of the shaft to case the distal end to open to a funnel shape. Inflation of a lower compliance inner inflatable expansile member can center the distal end of the shaft within a vessel, and inflation of a higher compliance outer inflatable member can provide atraumatic flow arrest to the vessel.

A catheter comprising: a shaft (1) having a proximal end (2) and a distal end (3), the distal end terminating in a tip (4); a drainage opening (7) located at the distal end of the shaft, the drainage opening communicating with a drainage lumen (8) of the shaft; a balloon located at the distal end of the shaft, the balloon comprising a first region secured to the shaft, a second region secured to the shaft and an elastic-walled conduit extending between the first region and the second region, the elastic conduit extending over the tip.

Devices and methods for providing an internal balloon sheath are disclosed. One device includes a sheath for insertion through an arteriotomy of a patient. The sheath comprises a tubular sheath body having a longitudinal axis, an open proximal end, an open distal end, an outer surface and an inner surface, the inner surface defining a lumen between the proximal and distal ends for passage of a catheter device. The sheath also comprises an inflatable balloon disposed within the lumen. The inflatable balloon is configured to occupy a longitudinal space in the lumen between the inner surface of the sheath body and the catheter device when the catheter device is disposed within the sheath and the balloon is inflated, and fluidically seal the lumen.

A balloon catheter is described having a reinforced, co-axial, duel lumen design. In some embodiments, the balloon catheter includes a purging mechanism designed to purge air from the balloon.