The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.

Devices systems and methods are disclosed for removing secretions from the lumen of a functional assessment catheter for the lungs. The system comprises a flushing unit configured to deliver a clearing fluid to the lumen of the pulmonary catheter to remove debris, secretions, or moisture from the lumen or sensors.

The disclosure relates to devices and methods for the treatment of edema using a purge-free system. The invention provides devices and methods useful for treating edema by means of an indwelling catheter that is placed in a blood vessel of a patient and used to pump blood to cause a decrease in pressure at an outlet of a lymphatic duct. The catheter pumps blood by means of an impeller but is purge-free in that the catheter does not include a system for purging or flushing catheter components with a purge fluid. The purge-free catheter avoids blood-related mechanical complications such as clotting or thrombosis by means of an impermeable sleeve or shroud that protects moving parts of the impeller drive system.

A device for stabilizing catheters such as delivery catheters is disclosed. The device includes a radially expandable structure which extends from a proximal end to an opposing distal end. The expandable structure is secured to a stabilizer catheter at its proximal end. The device includes means to position the delivery catheter relative to the expandable structure. The means may include one or more attachment members arranged to extend distally from the distal end of the expandable structure. Each attachment member is coupleable to a connector projecting near a distal tip of the delivery catheter. The means may alternatively include one or more sleeves, each arranged for the respective one of the delivery catheters to insert therethrough. A retractable catheter sheath is moveable along the longitudinal axis of the expandable structure to extend the expandable structure between a compressed configuration and an expanded configuration. A kit for stabilizing catheters is also enclosed. The kit includes a delivery catheter. The delivery catheter may comprise a connector projecting near a distal end thereof for coupling the attachment member. A method of use of the device for the delivery of biocompatible materials is also disclosed.

This document describes rotational atherectomy devices and systems for removing or reducing stenotic lesions in blood vessels by rotating an abrasive element within the vessel to partially or completely remove the stenotic lesion material.

In various aspects, the invention relates to an embolic device for treating aneurysms or other vascular disorders that exhibits improved filling and/or neck blockage over conventional devices. As one example, the embolic device can include a structure that is wound into a spiral shape. In some cases, the spirally wound embolic device includes alternating narrow portions and link portions. As another example, the embolic device can be formed from a structure wound to form an infinity shape or, in some cases, multiple infinity shapes. In instances with multiple infinity shapes, the infinity shapes can be arranged either parallel or perpendicular to each other. In certain aspects, the embolic device can include two different embolic devices that are attached by an interconnect element, such that the two devices are attached but have independent freedom of motion when placed within a vascular disorder.

A catheter system can include a tubular body, and at least one of a targeting system coupled to the tubular body, an expandable member, or a fluid injection port. A method of identifying a bifurcation can include inserting a catheter system into a first vessel, positioning the catheter system at a first location, expanding an expandable member to occlude the first vessel, delivering contrast material so the contrast material pooling proximate to the expandable member, and reviewing a shape of the contrast material in the first vessel under fluoroscopy.

Systems for imparting pulsatile energy to cardiovascular tissue are provided. Aspects of the systems include a console assembly comprising a potential source, a manifold assembly operably connected to an output of the console assembly, wherein the manifold assembly comprises an oscillator configured to generate pulse energy from energy transmitted from the potential source and a catheter assembly operably connected to an output of the manifold assembly. Catheter assemblies of the present invention include a connector operably connecting the catheter assembly to the manifold assembly and configured to transduce a first pulse energy generated by the manifold assembly to a second pulse energy, a catheter comprising a fluidic passage operably connected to the output of the connector and configured to transmit the second pulse energy and a heart-tissue-conforming element configured to receive the second pulse energy transmitted through the fluidic passage of the catheter to apply pulsatile energy to cardiovascular tissue. Also provided are methods for imparting pulsatile energy to cardiovascular tissue, e.g., deploying a system so that a heart-tissue-conforming element of the system is adjacent to cardiovascular tissue and engaging the system in a manner that the heart-tissue-conforming element imparts energy to the cardiovascular tissue. In addition, standalone catheter assemblies as well as kits comprising components of the systems described herein are provided. The systems, assemblies, methods and kits find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments.

A device for stabilizing catheters such as delivery catheters is disclosed. The device includes a radially expandable structure which extends from a proximal end to an opposing distal end. The expandable structure is secured to a stabilizer catheter at its proximal end. The device includes means to position the delivery catheter relative to the expandable structure. The means may include one or more attachment members arranged to extend distally from the distal end of the expandable structure. Each attachment member is coupleable to a connector projecting near a distal tip of the delivery catheter. The means may alternatively include one or more sleeves, each arranged for the respective one of the delivery catheters to insert therethrough. A retractable catheter sheath is moveable along the longitudinal axis of the expandable structure to extend the expandable structure between a compressed configuration and an expanded configuration. A kit for stabilizing catheters is also enclosed. The kit includes a delivery catheter. The delivery catheter may comprise a connector projecting near a distal end thereof for coupling the attachment member. A method of use of the device for the delivery of biocompatible materials is also disclosed.