A liquid injectable pharmaceutical drug product consisting of no less than 99 percent ethanol comprised of no less than 99 percent ethanol active pharmaceutical ingredient with a volume of at least 0.05 mL to be injected into a patient as a method of ablating/lysing cells.

The current document is directed to length-adjustable catheters and methods that employ length-adjustable catheters to treat malformations, constrictions, obstructions, lesions, and blockages within patients' blood vessels. The length of the shaft of a length-adjustable catheter, to which the current application is directed, can be adjusted over a range of lengths prior to and during medical procedures. In many implementations, length adjustment is accompanied by indications, to the medical provider, of the extent of a length adjustment. The indications may include one or more of visual markings, haptic feedback, radio-opaque markings, and/or other types of indications. In many implementations, the variable-length mechanism of the length-adjustable catheter is mechanically lockable following length adjustment.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery.

An implant delivery system including a catheter having a delivery lumen; a pusher member slidably disposed in the catheter delivery lumen; a retaining member coupled to a distal end portion of the pusher member, the retaining member configured to retain an expandable implant in a collapsed configuration on the pusher member for delivery of the implant through the catheter delivery lumen; and an expandable actuator coupled to the distal end portion of the pusher member and operatively associated with the retaining member, wherein expansion of the actuator causes the retaining member to disengage from an implant carried on the pusher member, to thereby allow the implant to expand from the collapsed configuration.

A snare particularly desirable for removing retrograde wires from blood vessels includes a rail wire attached to an inflatable/collapsible balloon of biocompatible semi-compliant resilient plastic material in a fixed wire configuration, or the balloon has a rapid exchange or over-the-wire lumen upon which the balloon may ride along a separate guide wire already in place. An additional lumen or cavity is defined by or within the balloon allowing the capture of objects, such as retrograde wires, within the lumen or cavity when the balloon is deflated. Desirably a central lumen is defined by biocompatible semi-compliant plastic material, or the balloon has a pair of arms so that a bridge wire extending between the pair of arms defines a cavity which can receive objects. An object for repositioning or removal is captured by the gripping action of the balloon assembly alone, without need for the utilization of a conventional snare.

A catheter according to an embodiment of the present disclosure includes a mesh member, a first hollow shaft, a front end tip, a guiding film, a second hollow shaft, and a core wire. The mesh member has a tubular shape and is radially expandable and contractable. The guiding film is disposed on the mesh member and has a front end located between a base end of the front end tip and a front end of the first hollow shaft. A thickness of the front end of the guiding film is larger than a thickness of a portion where a thickness of the guiding film is the smallest.

A catheter according to an embodiment of the present disclosure includes a mesh member, a first hollow shaft, a front end tip, a guiding film, and a core wire. The mesh member has a tubular shape and is radially expandable and contractable. The guiding film is formed with a stretchable material and is disposed on the mesh member, the guiding film having a front end located between a base end of the front end tip and a front end of the first hollow shaft. A thickness of a base end of the guiding film is larger than a thickness of the front end of the guiding film.

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include an inflatable balloon coiled in a helical manner around a central axis into a series of windings. An inner surface of the series of windings, when inflated, can define a passage through the inflatable balloon. A catheter can also include an elongate shaft extending from a proximal portion to a distal portion, having an inner surface that defines a lumen for providing inflation fluid to, or withdrawing inflation fluid from, a distal end of the inflatable balloon. A catheter can further include a guidewire support tube including a lumen, separate from the lumen from the elongate shaft and the passage through the inflatable balloon, for receiving a guidewire.

An intravascular balloon catheter device for treating various size stenosed regions within a blood vessel is provided. A clamp located within a body of a handle assembly is movable between a clamped and unclamped position by way of a button. When clamped, an outer member is secured relative to a sheath to as to expose a portion of a balloon located on a distal end of the outer member. The portion of the balloon remaining within the sheath is restricted from inflation beyond the sheath.

PTA catheters and improved PTA methods address problems associated with PTA procedures. One or more stabilizers are activated to hold or fix the PTA catheter at a desired relative position within a support catheter. Timely activation of the stabilizers can prevent deformation of the PTA apparatus during manipulation of the PTA apparatus within biological vessels.