Devices, systems, and methods are disclosed that help deliver catheters or other medical devices to locations within a patient's body. The device includes a transporter catheter having a proximal end and a distal end, at least a first balloon located adjacent to the distal end, and at least a second balloon located between the first balloon and the proximal end of the transporter catheter. The first balloon is configured for holding a prosthetic device in place. In another embodiment, the transporter catheter has a third balloon, an orienting balloon, substantially at the tip of the distal end of the transporter catheter.

Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over-active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

The disclosure includes a vein ablation system, comprising a catheter having an elongated body. In some embodiments, the vein ablation system comprises an ablation device at a distal portion of the elongated body. According to some embodiments, the vein ablation system comprises a control device at a proximal portion of the elongated body. The control device may comprise an input mechanism configured to simultaneously control at least two of a longitudinal translation of the ablation device through a target vessel, a rotation of the ablation device about a central longitudinal axis, and an infusion of a chemical agent into the target vessel.

The present disclosure is directed toward a semi-compliant to non-compliant, conformable balloon useful in medical applications. Conformable balloons of the present disclosure exhibit a low straightening force when in a curved configuration and at inflation pressures greater than 4 atm. Balloons of the present disclosure are constructed of material that can compress along an inner length when the balloon is in a curved configuration. In further embodiments, balloons of the present disclosure can be constructed of material that sufficiently elongates along an outer arc when the balloon is in a curved configuration. As a result, medical balloons, in accordance with the present disclosure, when inflated in a curved configuration, exhibit kink-free configurations and do not cause a significant degree of vessel straightening.

A device for introduction into a body vessel includes a shaft, a balloon positioned at the distal end of the shaft, a guidewire disposed longitudinally within the shaft to receive a guidewire during use, a balloon disposed at the distal end of the shaft, and longitudinal scoring wires to score a vascular lesion attached to the distal end of the shaft, disposed over the balloon and disposed within the shaft. The proximal ends are welded or otherwise affixed to a spring mounted in the handle. The balloon expands when fluid is delivered to the balloon through the inflation lumen. This expansion pushes the scoring wires against the vascular lesion.

A microneedle balloon catheter includes a balloon fluidically coupled to a first fluidic channel and microneedles fluidically coupled to a second fluidic channel. The microneedles are on an exterior surface of the balloon. The catheter also includes a guiding sheath. In a first position of the microneedle balloon catheter the balloon, the microneedles, and a portion of the first and second fluidic channels are housed within the guiding sheath. In a second position of the microneedle balloon catheter the balloon and the microneedles are arranged outside of the guiding sheath. The first and second fluidic channels are fluidically isolated from each other.

A catheter is provided for both crossing a lesion, such as a chronic total occlusion, in a vessel and performing percutaneous transluminal angioplasty thereupon. The catheter includes a shaft having a tapered tip adapted for being pushed into the lesion to advance through the lesion. An inflatable balloon is mounted on the shaft, which may be braided to provide enhanced pushability and kink-resistance. The inflatable balloon includes a proximal portion and a distal tapered portion connected to the tapered tip, and having a shallow taper. The taper of the distal tapered portion and the tapered tip may together create a continuous sloping transition from a distal end of the distal tapered portion to an adjacent portion of the tapered tip to facilitate crossing a lesion. The balloon may also be selectively inflated or deflated during crossing of the lesion, and ultimately used to compact the lesion when inflated.

An apparatus and methods tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, a plurality of serial balloons positioned on a translucent distal segment of the catheter shaft proximal to the distal tip and positioned inside of and concentric with a second distal balloon, the plurality of serial balloons in fluid communication with an inflation source via a first lumen, each of the plurality of serial balloons having a selectively expandable outermost radial surface. The plurality of serial balloons may include a translucent material, a series of isolated volumetric regions positioned between the plurality of serial balloons and recessed from the outermost radial surfaces of the serial balloons. The apparatus may include a distal balloon positioned around the plurality of serial balloons, and a light fiber positioned in the catheter shaft and extending through the translucent distal segment.

Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may optionally include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall. The methods may include delivering a first fluid out of one or more needles, and delivering a secondary fluid (which may be the same type of fluid as the first fluid, or a different type of fluid) from the device without delivering the secondary fluid through a needle.