A perfusion catheter for drug delivery to tissue, the perfusion catheter comprising: an elongate catheter shaft having a proximal end region and a distal end region and including an inflation lumen extending between the proximal end region and the distal end region; a balloon positioned adjacent to the distal end region of the elongate catheter shaft and in fluid communication with the inflation lumen, the balloon being configured to move between an collapsed configuration and an expanded configuration where a first region of a surface of the balloon defines a perfusion channel; and a therapeutic coating disposed on a second region of the surface of the balloon, wherein the second region is configured to contact the tissue in the expanded configuration.

Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.

This disclosure relates to a catheter system that for precisely positioning fluid flow restrictors within a blood vessel. In particular, this disclosure provides a catheter system that includes a sheath with a first fluid flow restrictor mounted thereto, and a catheter that is slidably disposed within the sheath and has a second fluid flow restrictor mounted thereto. Inside a blood vessel, the sheath and the catheter are separately slidable, thereby allowing the first and second fluid flow restrictors to be positioned at precise locations within the blood vessel.

A vascular catheter includes a catheter shaft having a distal end, a proximal end, a handle, at least two occlusion elements adapted to isolate a volume of the blood vessel, and an expandable balloon, between the two occlusion elements. The catheter shaft includes a first hole that opens into the expandable balloon. The catheter handle includes a first pumping device associated with a first path and with a first tank containing a first fluid, a second pumping device associated with a second path and with a second tank containing a second fluid, and a synchronization device connectable both to the first and to the second pumping devices.

A balloon catheter includes a shaft, first balloon, second balloon, first inflation tube, and second inflation tube. The first inflation tube has a lumen in communication with the lumens of the shaft and first balloon, and the second inflation tube has a lumen in communication with the lumens of the shaft and second balloon. The shaft has a first section on a distal side where the first and second inflation tubes are disposed, and a second section proximal to the first section where the first and second inflation tubes are disposed. At least two of the shaft, first inflation tube, and second inflation tube are fixed to each other in the first section. The shaft, first inflation tube, and second inflation tube are not fixed to each other in the second section. The balloon catheter is less likely to generate a kink when inserted into bent portions of blood vessels.

A multi-lumen implantable device configured to deliver a therapeutic agent to a selected portion of a blood vessel is disclosed. As one example, an implantable device includes a first lumen configured to flow blood from an upstream end to a downstream end of the device when implanted in a blood vessel; a second lumen fluidly separated from the first lumen and configured for introducing a therapeutic agent to a selected, first portion of a wall of the blood vessel, between the upstream end and the downstream end of the device; and at least one sealing member configured to block the therapeutic agent from entering a second portion of the wall of the blood vessel, between the upstream end and the downstream end of the device.