A graft system may be provided. The graft system may include a graft, a hemostasis valve operably coupled to a proximal end of the graft, and a clamp disposed around the proximal end of the graft and configured to hold the hemostasis valve in place relative to the graft. The graft may include a woven or knitted fabric. The clamp may be removably, or permanently, attached to the graft. The hemostasis valve may include a slit membrane disposed within a housing. The hemostasis valve may include an introducer sheath coupled to the housing. The housing may include two portions coupled together along two axial seams, each axial seam extending from a proximal end to a distal end of the hemostasis valve. A grommet may be coupled to an end of the graft.

The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

An implantable medical device for delivering therapeutic fluid to, and withdrawing cerebrospinal fluid (CSF) from, a CSF-containing space, includes a first inlet configured to be accessed by a needle of an aspiration device; a first outlet; a first fluid pathway extending from the first inlet to the first outlet; a second inlet; a second outlet; and a second fluid pathway extending from the second inlet to the second outlet. The first fluid pathway is free of a filter configured to prevent passage of a microbe.

Holding arrangements for a surgical access assembly are disclosed. One holding arrangement includes a body portion, an engagement barrel and a retaining member. The retaining member is configured as a hook at a distal end of the body portion and is sized to partially encircle a portion of an outer sheath. The engagement barrel is position on a proximal end of the body portion and is configured to be operatively connected to a surgical holding arrangement.

A cannula for connecting a medical device to a biological system is taught. The cannula includes a tissue engagement portion, preferably in the form of an annulus, to which a vacuum is applied through the cannula to attract and hold tissue of the biological system in an initial connection while an affixment device is applied to complete the connection. In addition to a working fluid conduit, comprising a main port, a working fluid passage and a working fluid port, and a port to apply the vacuum, the cannula can include a sensor port to allow sensing pressure or other characteristics of the working fluid at a point closely adjacent to the connection between the cannula and the biological system.

An access assembly is provided. The access assembly includes an access member defining a central longitudinal axis and having a longitudinal opening therethrough for reception and passage of surgical instrument, the access member dimensioned for positioning within tissue to provide access to underlying tissue, and first and second seal members mounted to the access member in juxtaposed relation, the first seal member defining an opening therethrough, the second seal member defining an elongated arcuate passage, wherein the first and second seal members are adapted for rotational movement about the central longitudinal axis whereby the opening of the first seal member is axially alignable with the elongated arcuate passage of the second seal member to permit reception and passage of the surgical instrument in substantial sealed relation therewith, the first and second seal members further adapted for relative rotational movement whereby the first seal member is capable of rotating relative to the second seal member during manipulation and traversal of the surgical instrument through the elongated arcuate passage of the second seal member to maintain the substantial sealed relation about the instrument.

Dural repair devices that are configured to effectively and reliably repair the damage of a dural tear due to incidental durotomies are provided, along with methods of use. The devices and methods enhance the ability of a surgeon to repair a patent's dura mater, or dura, during surgery of the central nervous system. The dural repair device has a multi-layer structure configured to exert a pressure or tamponade effect to compress a patient's dura to its state prior to the spinal surgery. Thus, the dural repair devices and methods of use may reduce the patient's risk morbidity, further surgery, spinal headaches, or other injuries and discomforts.

An implantable device for venous or peritoneal access including a housing including a void having distal a proximal openings; an insert for insertion through the proximal opening comprising a venous or peritoneal catheter; a valve element mounted in a cylindrical recess of the insert; an extracorporeal coupling member of which a terminal portion can be inserted into a proximal recess of the valve element; one or two conduits extending from the catheter to the proximal end of the coupling member via the valve element and the insert for providing fluid communication, which can be interrupted by rotating the coupling member. The coupling member can be extracted from the recess only in a state of interrupted communication.

A device for providing fluid access to a mammals central nervous system comprising: a fluid port allowing the fluid access; a housing comprising an extracorporeal portion and a lowermost surface to engage with the skull; and a fluid tube connected to the fluid port and extending below the housing. In various aspects: no part of the housing extends below the lowermost surface and the fluid tube bends to run along a trench in the skull; the lowermost surface comprises teeth; a septum seals the fluid port and a cap engages with the extracorporeal portion to compress the septum; and the device comprises a guide member and a connector having needles for fluid connection via the fluid port engages with the guide member, where, upon engagement of the connector and guide member, the needles adopt predetermined positions. Also provided is a method of implanting the device.

A surgical evacuation port device for removing fluid from a surgical site including a body having a distal opening, a primary evacuation opening, and a primary lumen extending from the distal opening to the primary evacuation opening. The surgical evacuation port device also includes an access port defining an access port lumen that is in fluid communication with the primary lumen. A sealing device and/or valve is coupled to the access port and configured to receive an access tool while maintaining pressure within the primary lumen.