A variable volume infusion port is provided. The infusion port may include a port body having an internal fluid reservoir, a septum, a stem to fluidly couple to a catheter lumen, and a displaceable member disposed in the internal fluid reservoir. In a first position, the displaceable member is disposed proximate the septum, providing a relatively small fluid volume within the infusion port. Insertion of an injection device through the septum causes the displaceable member to move to a second location distal from the septum, providing a relatively large fluid volume within the infusion port for the duration the injection device remains in the infusion port. The displaceable member may include a rigid member operably coupled to a biasing element or a flexible member coupled to a biasing element.

A fluid interface device for delivering fluid to and/or withdrawing fluid from a patient, the device comprises a peripheral base element (2) and a fluid transmission element (4) sealingly connected to the base element and forming a central portion of the device. The fluid transmission element comprises a front platelet (6) with a primary face (8) and a secondary face (10) opposed thereto, the primary face being in contact with a patient's body fluid region (12) when the device is implanted in the patient, the fluid transmission element further comprising a counterplate (14) sealingly stacked against the secondary face of the front platelet and forming a buffer volume (16) therebetween. The front platelet comprises at least one array of microchannels (18) defining a fluid passage between the buffer volume and the primary face, the microchannels having an opening of 0.2 to 10 μm. The counterplate has at least one fluid port (20; 20a, 20b) for fluid delivery to and/or fluid withdrawal from the buffer volume.

A stabilizing connector includes a connector portion and a stabilization portion. The connector portion is configured to couple to an access device. The connector portion defines at least one lumen that is configured to be placed in fluid communication with a lumen of the access device. The stabilization portion is coupled to the connector portion. The stabilization portion is configured to be placed in contact with a surface of a patient's skin to stabilize at least one of the stabilizing connector or the access device.

A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a lower opening configured to connect to a subdural space of a patient and an upper opening. A blockage removal unit is in the housing, and the blockage removal unit has an end portion that is configured to reduce or remove blockages adjacent the lower opening of the drainage passageway that is movable between a retracted position in which the end portion is in the subdural drainage housing and an extended position in which the end portion of the blockage removal unit extends away from the subdural drainage housing via the lower opening of the drainage passageway. At least one side delivery port is in the housing and in fluid communication with the drainage passageway.

Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include an apparatus for the creation, modification and maintenance of a fistula, including the modification of an existing dialysis fistula; and a method of supplying oxygenated blood to the venous circulation of a patient. A kit of anastomotic implants is described which supports a broad base of patient anatomies and fistula locations. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.

Valve devices are provided for draining fluids from and/or infusing fluids into a patient's body that include a housing including first, second, and third connectors, a primary fluid path communicating between the first and second connectors, and a secondary fluid path communicating from the primary fluid path to the third connector. First and second valve members are movable within the housing between first positions wherein the valve members do not obstruct the primary fluid path and second positions wherein the primary fluid path is at least partially closed. The third connector may be configured to prevent fluid flow therethrough unless a mating connector is fully coupled thereto. The valve members may be selectively closed to isolate portions of the flow path to allow a source of vacuum or fluid coupled to the third connector to aspirate or infuse fluid along portions of the primary fluid path.

The present invention relates to a multi-reservoir port, catheter, and non-coring needle system that supports high-flow applications such as hemodialysis and apheresis. In particular, the invention relates to improvements to provide optimal flow rates, septum life, and septum/needle stability when introducing fluid into the multi-reservoir port.

Fixation and protective components for use with implantable medical devices, such as access ports and catheters, are disclosed. In one embodiment, a protective sleeve is employed about a catheter so as to distribute compressive loads and ensure patency of the catheter lumen, even in areas prone to pinch-off. A catheter assembly in one embodiment thus comprises an elongate catheter tube that defines at least one lumen. A protective mesh sleeve is disposed about an external portion of the catheter tube so as to cover at least a portion of the longitudinal length of the catheter tube. The protective sleeve is configured to distribute a compressive load on the catheter tube so as to ensure patency of the at least one lumen of the catheter tube.

The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.

The disclosed antimicrobial device securely attaches to an underlying substrate such that the insertion needle can puncture though the antimicrobial device for easy application and antimicrobial protection of the insertion needle. The antimicrobial device comprises a contact dressing with a contact dressing first surface and contact dressing second surface, opposite the contact dressing first surface. The contact dressing first surface has an adhesive and an antimicrobial agent. The insertion needle is inserted through the contact dressing. The adhesive and antimicrobial agent are on the contact dressing first surface adjacent the inserted insertion needle.