A device for the uninterrupted administration of fluid to an animal body during a draw of bodily fluid, e.g., blood, is disclosed. A first fluid channel is configured to selectively transport IV fluid to an animal body and to draw a bodily fluid from the body. A sealing member for sealing a bodily fluid draw port defines a concave surface on a first end. The sealing member concave surface forms an interior surface portion of the first fluid channel. A connection member is configured to connect to a catheter to the first fluid channel and defines a concave distal end. A second fluid channel continuously provides IV fluid to a lumen coaxially located within the catheter. The concave surface and the concave distal end are shaped to create fluid flow patterns that quickly and completely remove residual bodily fluid remaining after a draw of bodily fluid is completed.

A system for attachment of a device to a bone is provided. The system includes an internal axial rod with a proximal and distal end that is configured to be inserted and secured into a bone cavity’s distal end. The system can also include an internal-external transfer rod with a proximal and distal end mounted into the distal end of the axial rod and a central channel extending through the transfer rod from the proximal end to the distal end and a plurality of attachment rings for attaching at least one tissue or muscle group to the transfer rod. The system also includes a bio-compatible and bio-occlusive artificial membranes (BIOCAMS) lamina, wherein the lamina includes either a polyetheretherketone (PEEK) mesh, a biocompatible polymer, a carbon fiber polymer, an artificial tissue polymer, molded donor tissue, allogenic tissue, a collagen/hyaluronic acid-based tissue, or connective tissue biosynthetic substrate material suitable as webbing.

The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.

An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, for instance, the arteriovenous graft systems includes a first valve device positioned at the arterial end and a second valve device positioned at the venous end. In one embodiment, the valve devices may include an inflatable balloon that, when inflated, constricts and closes off the arteriovenous graft. If desired, a single actuator can be used to open and close both valve devices.

A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.

An implantable access port including a port housing that defines a fill port cavity and includes a catheter fitting, a filter positioned within the port housing along a delivery flow pathway configured so that fluid injected into the fill port cavity passes through the filter prior to exiting through the catheter fitting, a one-way valve positioned within the port housing along an aspiration flow pathway configured to permit aspirated fluid to flow unfiltered from the catheter fitting to the fill port cavity and prevent injected fluid from flowing unfiltered from the fill port cavity to the catheter fitting, a port cover coupled to the port housing, and a pierceable septum positioned between the fill port cavity and the port cover configured to allow a needle to pierce through the pierceable septum to access the fill port cavity.

An intrathecal drug delivery system including an intrathecal drug delivery device configured to deliver a fluid containing one or more pharmaceutical agents intrathecally to CSF within a spinal canal of a patient, a deep brain catheter having an elongated body extending from distal end is configured implanted within a deep brain structure of a patient and a proximal end positioned within the subarachnoid space directly adjacent to the brain to provide a passageway via an inner lumen between subarachnoid space and the deep structure. The drug delivery system configured to transport the pharmaceutical agent using diffusion and pulsatile flow of the CSF through the deep brain catheter from the subarachnoid space to the deep brain structure.

Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

A chest valve including: a housing including an inlet configured to connect to a chest tube, an outlet and a fluid passage from the inlet to the outlet; and a one-way valve within the housing and included in the flow passage, wherein the one-way valve includes: (i) a first tubular strip wherein having an internal air passage and a first layer defining the air passage, wherein the first layer has a first thickness and the internal air passage of the first tubular strip is included in fluid passage of the housing; and (ii) a second tubular strip wherein having a second layer with a second thickness with a second thickness greater than the first thickness, wherein an outer surface of the second tubular strip is adjacent and overlaps an outer surface of the first tubular strip.

Described herein are negative pressure drains configured as “rolling” surgical drains including an invertible porous mesh having an expanded configuration so that negative pressure may be applied out of the invertible porous mesh to extend a uniform negative pressure within the body region being treated. The invertible porous mesh may then be withdrawn into the apparatus without significantly disrupting the tissue.