A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Methods and devices for eradicating biofilms and planktonic bacteria are provided. In on embodiment, a therapeutic delivery device comprised of at least a port and a antimicrobial releasing pouch and one or more therapeutic agents is provided to the mammal. In one aspect of at least one embodiment the releasing pouch has an internal reservoir comprised of a membrane that is configured to contain the one or more therapeutic agents that is to be administered to the mammal and the port is in fluid communication with the pouch and configured such that the pouch can be refilled with one or more therapeutic agents via the port. In other aspect of at least one embodiment the method is able to fully eradicate 10.sup.9 colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA) within a 24 hr period.

A device and method for implanted port alleviation. The device including a dispensing cap having a compressible reservoir and a cover member, wherein the compressible reservoir is configured to hold a predetermined quantity of a topical anesthetic and the cover member is configured to cover an implanted port on the patient. An adhesive element attached to a top portion of the compressible reservoir configured to adhere to the skin of a patient. Advantageously, the compressible reservoir is positioned on top of the cover member such that when the compressible reservoir is compressed, the topical anesthetic is transferred to the cover member on the patient's skin above the implanted port numbing the patient's skin.

A port cap has a closed end, an open end, and a conical body made of a flexible material. An inside of the port cap may have a textured or uneven surface. The textured or uneven surface may be formed by one or more annular rings. An annular ring may be asymmetrical having different slopes on the two different sides of the annular ring. The port cap may be made of an elastomeric polymer or elastomeric copolymer. An insert inside the port cap may be made of a sponge or similar material and may contain a cleaning agent or microbiocidal. The port cap may be sealed with a lid. Methods of using the port cap are also disclosed.

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

An improved method and device are provided for forming and/or maintaining a percutaneous access pathway. The device generally comprises an access pathway and attachment device. The provided assembly substantially reduces the possibility of iatrogenic infection while accessing and/or re-accessing a body space.

Adapters for a connector assembly for percutaneous tubing are provided. A male adapter (FIG. 22a, 1000) includes a connector fitting (1002) proximate a first end, the connector fitting configured to join to a connector for a tubing system or device, and a male connector (656) proximate a second end. The male connector includes a plug end with a fluid lumen defined therethrough, the plug end having a circumferential groove defined therein to receive a locking extension of a female connector sized to be received within the circumferential groove of the plug end to allow the female connector to rotate relative to and maintain axial engagement with the male connector when the locking extension is received within the groove. An adapter having a female connector (FIG. 24, 1300) is also provided.

A method of treating a patient using a power-injectable access port, including implanting the power-injectable access port in the patient, imaging the power-injectable access port following implanting, and power injecting a fluid into the patient through the power-injectable access port. The power-injectable access port includes a septum covering a reservoir, the septum including a radiopaque material forming at least one letter, the at least one letter indicating that the power-injectable access port is suitable for power injection. The power-injectable access port is designed to accommodate a pressure developed within the reservoir of at least 35 psi, and a fluid flow rate of at least 1 milliliter per second. Imaging the power-injectable access port produces an image, and the method includes identifying the at least one letter on the image to confirm that the power-injectable access port is suitable for power injecting a fluid.

Connector assembly (FIG. 4a) includes a shell (210), a connector body (230), and a plug (250). The shell (210) has a sidewall (212) defining an interior, a first shell end having a first opening (214) defined therein, and a second shell end having a second opening (216) defined therein, each of the first (214) and second openings (216) in communication with the interior to receive percutaneous tubing therethrough, the shell (210) further having an engagement portion. The connector body (230) has a first body end (234) and a second body end (236) with a tube lumen defined therethrough, the first body end (234) having a connector tip (237), the connector body (230) having an engaging portion to engage the engagement portion of the shell (210). The plug (250) has a first plug end and a second plug end with a fluid lumen defined therethrough, the first plug end having a plug tip (257) extending therefrom.