A system to detect occlusion of an intravenous catheter may include a housing, which may include a distal end configured to couple to a proximal end of a catheter adapter and an inner lumen forming a fluid pathway. The system may also include one or more transmitters, which may be disposed within the housing. The transmitters may be configured to transmit first energy waves along a length of an intravenous catheter at a first frequency, and a portion of the first energy waves that are reflected back from the catheter may be detected by the system. Based on the portion of the first energy waves that are reflected back from the catheter, the transmitters may transmit second energy waves along the length of the catheter at a second frequency, which may be greater than the first frequency and configured to reduce formation of blood clots within the catheter.

A device for feeding a line through the skin of a patient, wherein the line contains a photodynamic substance that releases highly reactive oxygen derivatives when irradiated. Thus, disinfection/sterilization can be achieved in the region of a feed-through both on the outside of the skin and in the feed-through region by irradiating the feed-through.

A sterile tube connector for a fluid circuit system comprising a housing. A first opening is configured to receive a first length of tubing in communication with a first chamber. A second opening is configured for communicating with the first chamber when the tube connector is in an open configuration but not in a closed configuration. The second opening is configured to reversibly engage a third opening to form a second chamber. The third opening is configured for communicating with a second length of tubing. A first portion of the housing forming the first opening comprises a material at least partially permeable to a sterilization energy source for sterilizing contents of the second chamber.

A system to detect occlusion of an intravenous catheter may include a housing, which may include a distal end configured to couple to a proximal end of a catheter adapter and an inner lumen forming a fluid pathway. The system may also include one or more transmitters, which may be disposed within the housing. The transmitters may be configured to transmit first energy waves along a length of an intravenous catheter at a first frequency, and a portion of the first energy waves that are reflected back from the catheter may be detected by the system. Based on the portion of the first energy waves that are reflected back from the catheter, the transmitters may transmit second energy waves along the length of the catheter at a second frequency, which may be greater than the first frequency and configured to reduce formation of blood clots within the catheter.

Cyclic urea compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

A device is presented for disinfecting needleless connectors. The device has a housing that contains a UV light source. The UV light source is operably connected to a power source. The housing has a receptacle configured to selectively receive a shield. The shield has an inner reflective chamber with an internal surface that reflects UV light. In use, the UV light source can illuminate a needleless connector inserted within the shield.

A catheter connector includes an inner wall that defines an interior of the catheter connector and is transmissive to ultraviolet (UV) light. An outer wall defines an exterior of the catheter connector. One or a plurality of UV light sources is disposed between the inner wall and the outer wall or on the outer wall positioned to emit UV light into the interior of the catheter connector. A flow sensor is provided for sensing a flow of fluid in the interior of the catheter connector, and circuitry electrically connects the UV light sources, the flow sensor and a power source, such that electrical power is supplied to the UV light sources when a fluid flows through the interior of the catheter connector.

A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.

A disinfecting device having a housing and an ultraviolet source located in the housing. The disinfecting device may include a tube that includes a first end connected to the housing and a second end free of the housing. An end cap may be located at the second end of the tube. In use, ultraviolet light may be emitted from the ultraviolet source and propagated to the end cap in order to disinfect a portion of a medical device.

A gas delivery system (50) for delivering a flow of breathing gas to a patient (54) includes a blower assembly (100) structured to generate the flow of breathing gas. The blower assembly includes a gas flow path including an inlet manifold, an assembly (130) structured to adjust a pressure and/or flow rate of the flow of breathing gas, and an outlet manifold structured to be coupled to a patient circuit. The gas delivery system additionally includes a light system structured to generate sanitizing light and deliver the sanitizing light to one or more internal surfaces of at least one of the inlet manifold, the assembly and the outlet manifold for sanitizing the one or more internal surfaces.