Embodiments disclosed herein are directed to a connector for a fluid drainage system for fluidly coupling a catheter to a drainage tube. The connector includes a body defining a drainage lumen extending along a longitudinal axis from a distal portion to a proximal portion. The connector also includes a positive air pressure inlet and a valve slidably engaged with a valve housing along the longitudinal axis between a first position and a second position. The valve in the first position provides fluid communication between the distal portion and the proximal portion of the drainage lumen, and the valve in the second position occludes fluid communication between the proximal portion and the distal portion of the drainage lumen. Pressurized air provided at the inlet can transition the valve to the second position and clear any dependent loops within the drainage lumen.

A breakaway medical tubing connector includes a first side member comprising a first housing having an inner wall, a first channel disposed within the first housing, and a first valve disposed within the first channel, wherein the first valve is an active valve and wherein the first valve comprises a diaphragm forming a first seal with the inner wall. The apparatus includes a second side member comprising a second housing, a second channel disposed within the second housing, a second valve disposed within the second channel, and a cannula extending from the second side member toward the first side member. The apparatus further includes a toric joint between the cannula and the first side member, wherein the toric joint forms a second seal between the first and second side members.

A breakaway medical tubing connector and method for joining two sections of medical tubing includes a pump side member and a patient side member positioned axially opposite from the pump side member. The patient side member has a first channel disposed within the pump side member and a first valve disposed within the first channel. The pump side member has a second channel disposed within the patient side member and a second valve disposed within the second channel. The first valve may be an active valve and the second valve may be a passive valve. A securing bar may be disposed on the pump side member and a securing arm may be disposed on the patient side member for providing a detachable coupling of the two members.

In-line filter devices are described herein. An in-line filter device includes an inlet portion, an outlet portion, a first filter housing, a first flow path, and a first filter media. The first filter housing defining a first filter volume. The first flow path is defined between the inlet portion and the first filter volume to provide fluid communication between the inlet portion and the first filter volume. The second flow path is defined between the first filter volume and the outlet portion to provide fluid communication between the first filter volume and the outlet portion. The first filter media is disposed within the first filter volume, wherein the first filter media permits flow from the first flow path to the second flow path and captures particulate from the flow.

Methods and apparatus involve generation of an anti-infection therapy. The method/apparatus may include a controller controlling setting of a respiratory flow therapy device for the therapy. The controller may compute a target flow rate profile for a patient using a margin function, such that the target flow rate profile, according to the margin function, exceeds a minimum inspiratory flow rate profile of the patient's inspiration. The controller may control setting the respiratory flow therapy device to generate a flow of air to a patient interface according to the target flow rate profile, where the generation may be in synchrony with a sensed parameter that is indicative of a breathing cycle of the patient.

Needleless connectors are described herein. A needleless connector includes a body, a valve element at least partially disposed within the body, and a base. The valve element includes a cylindrical portion having an outwardly extending flange at a distal end. The flange has a bottom surface with an outer area and an inner area. The base includes a rim having a top surface that is in contact with an outer area of the flange of the valve element, the rim defining a recess with a bottom surface separated from the top surface of the rim, and at least one support member having a top surface spaced apart from the top surface of the rim and configured to resist deformation of the flange toward the recess.

Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.

A breakaway medical tubing connector and method for joining two sections of medical tubing includes a pump side member and a patient side member positioned axially opposite from the pump side member. The patient side member has a first channel disposed within the pump side member and a first valve disposed within the first channel. The pump side member has a second channel disposed within the patient side member and a second valve disposed within the second channel. The first valve may be an active valve and the second valve may be a passive valve. A securing bar may be disposed on the pump side member and a securing arm may be disposed on the patient side member for providing a detachable coupling of the two members.

Apparatus and methods of dispensing fluid intravenously to a subject, and of flushing a line of an intravenous fluid administration apparatus, are provided. The apparatus may include a chamber including a plurality of connector ports and be configured to operate in fluid communication with an upstream source via a first connector port and, during operation, pass therethrough to downstream tubing, under a first pressure condition, first fluid from the upstream source via a second connector port. A third connector port may be configured to connect to an end of tubing or a valve connector such that, during operation, the chamber is configured to, under a second, higher pressure condition, pass therethrough to the downstream tubing a second fluid from a second fluid source via the third and second connector ports, prevent first fluid flow into the downstream tubing, and prevent second fluid flow through the first connector port.

Apparatus and methods of dispensing fluid intravenously to a subject, and of flushing a line of an intravenous fluid administration apparatus, are provided. The apparatus may include a reservoir pump configured to operate in fluid communication with an upstream source of a first fluid and a downstream pressure-operated valve. The apparatus may also include a port connector configured to operate in fluid communication with at least the pressure-operated valve. The reservoir pump may also be configured to, during operation, automatically refill itself with the first fluid from the first upstream source. The downstream pressure-operated valve may be configured to operate in fluid communication with the reservoir pump and a second fluid source upstream of the pressure-operated valve, and to, during operation, dispense the first fluid to tubing downstream of the pressure-operated valve based on a pressure condition within the pressure-operated valve exceeding a threshold pressure.