Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal with a collar and without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal.

Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal with a collar and without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal.

Seals for medical fluid connectors are disclosed. A seal as molded may have an elliptical cross-sectional shape, an aperture on the top face of the seal, a well inside the seal, and a divet on the bottom face of the seal. The seal as molded becomes assembled when it is constrained by a housing. When constrained by the housing, the seal has a circular cross-sectional shape, and the aperture becomes an elongate insertion area. The elongate insertion area is closed such that fluid cannot permeate the seal as assembled. However, the seal as assembled is penetrable by a center post through the elongate insertion area, and the center post creates a fluid path through the seal when the center post penetrates the seal.

A connector system having a pair of connector components capable of being used as a reuseable aseptic connection in bioprocessing and/or cell manufacturing processes. Each connector component includes a connector housing having a mating surface with an opening and a door moveable to close and open the opening, and a connector assembly therein. The connector assembly includes a base member having a fluid port; an engagement piece having a pusher portion; and a valve unit therebetween, the valve unit having a resilient deformable valve member. The pusher portion is moveable to cause the pusher portion to urge open the resilient deformable valve member for enabling the fluid flow. When the pair of connector components are interlocked, the doors open and the connector assemblies move and engage with each other through the openings causing the resilient deformable valve members to open for establishing a fluid connection.