Disclosed is a Cannula system (CS1 to CS3, 210, 310, 1010, 1040, 1110) comprising: a first cannula (O1 to O3) having a minimum inner diameter or width, a second cannula (I1 to I3) having a maximum outer diameter or width, wherein the minimum inner diameter or width is greater than the maximum outer diameter or width, wherein the second cannula (I1 to I3) is adapted to be guided into the first cannula (O1 to O3) such that a first lumen of the first cannula (O1 to O3) remains in the first cannula (O1 to O3) between an outer surface the second cannula (I1 to I3) and an inner surface of the first cannula (O1 to O3), and wherein the first lumen of the first cannula (O1 to O3) defines a first fluid conduit and a first lumen of the second cannula (I1 to I3) defines a second fluid conduit.

In a method for intermittently occluding the coronary sinus, in which the coronary sinus is occluded using an occlusion device, the fluid pressure in the occluded coronary sinus is continuously measured and stored, the fluid pressure curve is determined as a function of time, and the occlusion of the coronary sinus is triggered and/or released as a function of at least one characteristic value derived from the measured pressure values. The pressure increase and/or pressure decrease per time unit each occurring at a heart beat are used as characteristic values.

An aortic adapter assembly is provided, including a T-shaped flow connector, including: an inserted conduit portion, having a blood-contacting surface which is smooth; an extruded neck portion, wherein the inserted conduit portion is joined with the extruded neck portion; and a truss, disposed in the inserted conduit portion; wherein the T-shaped flow connector has a polymeric elastomer reinforced by the truss having a Nitinol material; wherein the inserted conduit portion has an inner wall which is gradually thinning at two conduit ends of the inserted conduit portion, with a proper distance of a tip of the conduit end to the outmost boundary of the truss, and the conduit end possesses a compliance-matching effect to an implant site artery; wherein a proximal end of the extruded neck portion is configured to be joined with an inlet adapter of a blood pump. The aortic adapter assembly is accompanied with a quick-connector type coupler and a deployment method to accomplish an insertion type flow communication between a ventricular assist device and the human circulation.

An aortic adapter assembly is provided, including a T-shaped flow connector, including: an inserted conduit portion, having a blood-contacting surface which is smooth; an extruded neck portion, wherein the inserted conduit portion is joined with the extruded neck portion; and a truss, disposed in the inserted conduit portion; wherein the T-shaped flow connector has a polymeric elastomer reinforced by the truss having a Nitinol material; wherein the inserted conduit portion has an inner wall which is gradually thinning at two conduit ends of the inserted conduit portion, with a proper distance of a tip of the conduit end to the outmost boundary of the truss, and the conduit end possesses a compliance-matching effect to an implant site artery; wherein a proximal end of the extruded neck portion is configured to be joined with an inlet adapter of a blood pump. The aortic adapter assembly is accompanied with a quick-connector type coupler and a deployment method to accomplish an insertion type flow communication between a ventricular assist device and the human circulation.

In a method for intermittently occluding the coronary sinus, in which the coronary sinus is occluded using an occlusion device, the fluid pressure in the occluded coronary sinus is continuously measured and stored, the fluid pressure curve is determined as a function of time, and the occlusion of the coronary sinus is triggered and/or released as a function of at least one characteristic value derived from the measured pressure values. The pressure increase and/or pressure decrease per time unit each occurring at a heart beat are used as characteristic values.

The invention relates to a catheter assembly for the intermittent occlusion of the coronary sinus (CS, 60). The catheter assembly comprises a shaft (17, 126). The shaft (17, 126) has a plurality of lumens (7A, 7B, 35, 38, 40, 40A, 40B), a distal end (22) with a distal tip (20A, 20B, 20C), an occlusion device (24, 56, 142) fixed to the distal tip (20A, 20B, 20C) and operable through at least one of the plurality of lumens (7A, 7B, 35, 38, 40, 40A, 40B) and a proximal handle (10). The catheter assembly further having at least one of the following: the occlusion device (24, 142) having a diameter of 5 - 20 mm and adapted to occlude the coronary sinus ostium, means of measuring the pressure at the distal tip (20 a, 20B, 20C) of the catheter assembly and distally to the occlusion device (24, 142), preferably using an optical pressure sensor (28), an anchoring device (30, 54, 65, 80, 90A, 122) for anchoring the occlusion device (24, 142) in a predefined position in the coronary sinus (CS, 60), preferably in the ostium, the distal end (22) being deflectable/steerable with deflection being controlled by an actuator arranged at the proximal handle (10).

The invention relates to a catheter assembly for the intermittent occlusion of the coronary sinus (CS, 60). The catheter assembly comprises a shaft (17, 126). The shaft (17, 126) has a plurality of lumens (7A, 7B, 35, 38, 40, 40A, 40B), a distal end (22) with a distal tip (20A, 20B, 20C), an occlusion device (24, 56, 142) fixed to the distal tip (20A, 20B, 20C) and operable through at least one of the plurality of lumens (7A, 7B, 35, 38, 40, 40A, 40B) and a proximal handle (10). The catheter assembly further having at least one of the following: the occlusion device (24, 142) having a diameter of 5 - 20 mm and adapted to occlude the coronary sinus ostium, means of measuring the pressure at the distal tip (20 a, 20B, 20C) of the catheter assembly and distally to the occlusion device (24, 142), preferably using an optical pressure sensor (28), an anchoring device (30, 54, 65, 80, 90A, 122) for anchoring the occlusion device (24, 142) in a predefined position in the coronary sinus (CS, 60), preferably in the ostium, the distal end (22) being deflectable/steerable with deflection being controlled by an actuator arranged at the proximal handle (10).

Some systems and methods for treating heart tissue may include instruments for intermittently occluding the coronary sinus using a coronary sinus occlusion catheter device. In some embodiments, the coronary sinus occlusion catheter can be used before or during a coronary intervention procedure in which a blockage in a heart is repaired or removed.

An inflow cannula assembly intended for connecting a ventricular assist device (VAD) to a heart chamber without suturing anastomosis is provided. The inflow cannula assembly includes a deformable flow cannula with funnel-shaped bellmouth intake at a first end and a second end interfaced to the inlet of a VAD with minimal interface discontinuity; also includes is a pair of male and female fasteners that can be screw locked to fix and seal the cannula bellmouth against the endocardium for hemostasis purpose; as well as a VAD coupler and a VAD inlet adapter that enable a quick connection of the cannula with the VAD.

A para-aortic blood pump device includes a blood pump, an aortic adapter, a driveline, and a driver. The blood pump includes a blood sac, a pump housing and a pressure sensor, whereas the pressure sensor is installed in the pump housing for monitoring the blood pressure inside the blood pump. The aortic adapter is a T-manifold shaped conduit connected to the blood pump and is used for connecting the blood pump with human aorta to facilitate circulatory support. The driveline allows a pneumatic communication to the blood pump in addition to transmitting the electrical blood pressure signal to the driver. The driver receives and processes the electrical blood pressure signal, decides the timing, speed and duration of blood pump fill and eject actions so as to provide counter-pulsatile circulatory support to assist human circulation.