An example renal support pump includes a renal support device including an outer catheter shaft having a longitudinal axis and a distal end region coupled to a renal pump assembly, wherein the renal pump assembly includes a frame and an impeller assembly, wherein the impeller assembly is disposed within the frame, and wherein the impeller assembly is configured to rotate relative to the frame about the longitudinal axis of the catheter shaft.

A temporary, removable mechanical circulatory support heart-assist device has at least two propellers or impellers. Each propeller or impeller has a number of blades arranged around an axis of rotation. The blades are configured to pump blood. The two propellers or impellers rotate in opposite directions from each other. The device can be configured to be implanted and removed with minimally invasive surgery.

Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and kidney dysfunction. In response thereto, blood pressure within a renal vein of the subject is reduced, by placing a blood pump inside the subject's renal vein and activating the impeller to pump blood from the renal vein into the subject's vena cava. Other applications are also described.

The devices and methods described herein include an implantable body lumen fluid flow modulator including an upstream flow accelerator separated by a gap from a downstream flow decelerator. The gap is a pathway to entrain additional fluid from a branch lumen(s) into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator.

A system and method for cardiorenal syndrome (CRS) therapy are provided. The system may utilize a therapy-delivery device configured to be disposed within a patient. The therapy-delivery device may be, e.g., a blood pump, a blood flow or pressure restrictor or enhancer. The system may include a controller operably coupled to the therapy-delivery device. The controller may be configured to adjust a therapy delivered by the therapy-delivery device based on a parameter related to renal function. The parameter may be measured by a real-time diagnostic sensor. The real-time diagnostic sensor may be integral to the therapy-delivery device, or may be located remotely from the therapy-delivery device, such as on a separate implantable device, or on a wearable medical device.

A system and method for cardiorenal syndrome (CRS) therapy are provided. The system may utilize a therapy-delivery device configured to be disposed within a patient. The therapy-delivery device may be, e.g., a blood pump, a blood flow or pressure restrictor or enhancer. The system may include a controller operably coupled to the therapy-delivery device. The controller may be configured to adjust a therapy delivered by the therapy-delivery device based on a parameter related to renal function. The parameter may be measured by a real-time diagnostic sensor. The real-time diagnostic sensor may be integral to the therapy-delivery device, or may be located remotely from the therapy-delivery device, such as on a separate implantable device, or on a wearable medical device.

Systems and techniques for improving cardiorenal syndrome (CRS) may be provided. The systems may include a first flow enhancer configured to increase a renal artery pressure. The systems may include a second flow enhancer or flow restrictor configured to reduce a renal vein pressure. Each flow enhancer or flow restrictor may be configured to increase a transrenal pressure gradient, improve filtering and renal perfusion.

Systems and techniques for improving cardiorenal syndrome (CRS) may be provided. The systems may include a first flow enhancer configured to increase a renal artery pressure. The systems may include a second flow enhancer or flow restrictor configured to reduce a renal vein pressure. Each flow enhancer or flow restrictor may be configured to increase a transrenal pressure gradient, improve filtering and renal perfusion.

A blood flow assist system can include an impeller assembly including an impeller shaft and an impeller on the impeller shaft, a primary flow pathway disposed along an exterior surface of the impeller. The system can include a rotor assembly at a proximal portion of the impeller shaft. A secondary flow pathway can be disposed along a lumen of the impeller shaft. During operation of the blood flow assist system, blood can be pumped proximally along the primary flow pathway and the secondary flow pathway. The system can include a sleeve bearing distal the impeller. The system can include a drive unit having a distal end disposed distal a proximal end of the second impeller. The drive unit comprising a drive magnet and a drive bearing between the drive magnet and the impeller assembly.

Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of said first pump, wherein the struts secure the first pump in a desired location of the chamber or vessel. The system may also include one or more flow modification elements disposed on the first pump, where the flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired.