A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or to vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

An inflow cannula assembly intended for connecting a ventricular assist device (VAD) to a heart chamber without suturing anastomosis is provided. The inflow cannula assembly includes a deformable flow cannula with funnel-shaped bellmouth intake at a first end and a second end interfaced to the inlet of a VAD with minimal interface discontinuity; also includes is a pair of male and female fasteners that can be screw locked to fix and seal the cannula bellmouth against the endocardium for hemostasis purpose; as well as a VAD coupler and a VAD inlet adapter that enable a quick connection of the cannula with the VAD.

A para-aortic blood pump device includes a blood pump, an aortic adapter, a driveline, and a driver. The blood pump includes a blood sac, a pump housing and a pressure sensor, whereas the pressure sensor is installed in the pump housing for monitoring the blood pressure inside the blood pump. The aortic adapter is a T-manifold shaped conduit connected to the blood pump and is used for connecting the blood pump with human aorta to facilitate circulatory support. The driveline allows a pneumatic communication to the blood pump in addition to transmitting the electrical blood pressure signal to the driver. The driver receives and processes the electrical blood pressure signal, decides the timing, speed and duration of blood pump fill and eject actions so as to provide counter-pulsatile circulatory support to assist human circulation.

A para-aortic blood pump device includes a blood pump, an aortic adapter, a driveline, and a driver. The blood pump includes a blood sac, a pump housing and a pressure sensor, whereas the pressure sensor is installed in the pump housing for monitoring the blood pressure inside the blood pump. The aortic adapter is a T-manifold shaped conduit connected to the blood pump and is used for connecting the blood pump with human aorta to facilitate circulatory support. The driveline allows a pneumatic communication to the blood pump in addition to transmitting the electrical blood pressure signal to the driver. The driver receives and processes the electrical blood pressure signal, decides the timing, speed and duration of blood pump fill and eject actions so as to provide counter-pulsatile circulatory support to assist human circulation.

An implantable circulatory support system, configured to connect a ventricular chamber of a heart, including a valveless displacement blood pump, a deformable polymeric flow cannula, a pair of male and female fasteners, a coupler, a driveline assembly, and a co-pulsatile driver. Forward and backward flow communication between the blood pump and the heart chamber is accomplished using the present flow cannula invention which is anastomosed to the heart chamber in a sutureless manner. When providing circulatory support, the co-pulsatile driver ejects blood out of the blood pump during systolic ventricular contraction and fills the blood pump with blood during diastolic ventricular relaxation.

An implantable circulatory support system, configured to connect a ventricular chamber of a heart, including a valveless displacement blood pump, a deformable polymeric flow cannula, a pair of male and female fasteners, a coupler, a driveline assembly, and a co-pulsatile driver. Forward and backward flow communication between the blood pump and the heart chamber is accomplished using the present flow cannula invention which is anastomosed to the heart chamber in a sutureless manner. When providing circulatory support, the co-pulsatile driver ejects blood out of the blood pump during systolic ventricular contraction and fills the blood pump with blood during diastolic ventricular relaxation.

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

A pump system is provided for pumping a fluid and a method is provided for operating the pump system. The pump system comprises a first diaphragm fluid pump, a first inlet cannula connected to the first diaphragm fluid pump for supplying a fluid to the first diaphragm fluid pump, a first outlet cannula connected to the first diaphragm fluid pump for discharging the fluid out of the first diaphragm fluid pump, and a first service pump, which is connected via a first pressure line to the first diaphragm fluid pump and is confirmed to drive the first diaphragm fluid pump via the first pressure line. The pump system further comprises a first inlet flow sensor for detecting a first inlet flow of the fluid in the first inlet cannula and/or a first outlet flow sensor for detecting a first outlet flow of the fluid in the first outlet cannula.

A pump system is provided for pumping a fluid and a method is provided for operating the pump system. The pump system comprises a first diaphragm fluid pump, a first inlet cannula connected to the first diaphragm fluid pump for supplying a fluid to the first diaphragm fluid pump, a first outlet cannula connected to the first diaphragm fluid pump for discharging the fluid out of the first diaphragm fluid pump, and a first service pump, which is connected via a first pressure line to the first diaphragm fluid pump and is confirmed to drive the first diaphragm fluid pump via the first pressure line. The pump system further comprises a first inlet flow sensor for detecting a first inlet flow of the fluid in the first inlet cannula and/or a first outlet flow sensor for detecting a first outlet flow of the fluid in the first outlet cannula.

Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one adjustable component designed to cause blood to flow in a direction opposite to the normal direction (regurgitation) within the patient's heart; and a controller configured for adjusting the function of the at least one adjustable component based at least in part on sensor data from the at least one sensor.