Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, a centrifugal pump is used. In an embodiment, inlet and outlet ports are connected into the aorta and blood flow is diverted through a lumen and a centrifugal pump between the inlet and outlet ports. The supports may create a pressure rise between about 40-80 mmHg, and maintain a flow rate of about 5 L/min. The support may be configured to be inserted in a collinear manner with the descending aorta. The support may be optimized to replicate naturally occurring vortex formation within the aorta. Diffusers of different dimensions and configurations, such as helical configuration, and/or the orientation of installation may be used to optimize vortex formation. The support may use an impeller which is electromagnetically suspended, stabilized, and rotated to pump blood.

A pump catheter for the directed pulsatile conduction of blood includes a proximal section and a distal section which has an expandable pump chamber and a tube section arranged distally from the pump chamber. The tube section has an outlet opening. An inlet element having at least one inlet opening is arranged between the proximal section and the pump chamber and the inlet element and the pump chamber are geometrically spaced apart by a coupling element.

A device for reducing pressure within a lumen includes a reservoir structured for holding a fluid therein, an injection port in fluid communication with the reservoir, a compliant body structured to expand and contract upon changes in pressure, and a conduit extending between and fluidly coupling the reservoir and the compliant body. The fluid may be a compressible or a noncompressible fluid.

A ventricular assist system including an implantable rotary pump, a pump drive circuit for supplying power to the pump, and a signal processing circuit receiving one or more electrophysiological signals and one or more physiological signals of the subject. The signal processing circuit is operable to receive inputs from the one or more electrophysiological sensors and the physiological sensor, and determine the presence or absence of a non-normal sinus cardiac rhythm condition based on the input from the electrophysiological sensors. In the presence of a non-normal sinus rhythm, the circuit operates the pump in a modified mode of operation. In the absence of a non-normal sinus rhythm, the circuit operates the pump in a normal mode of operation. In either case, the circuit controls the power to the pump and/or speed of the pump based on the input from the physiological sensor and the mode of operation.

The present invention relates to a supply device for a channel (8), in particular within a hollow catheter (1), and to a method for operating a supply device of this type that supplies a channel (8) with a liquid and has two pumps (10, 19) arranged at points of the channel distanced from one another, characterised in that the parameter values of at least one operating parameter of both pumps are coordinated with one another in a controlled manner. As a result of the method, interruption-free and precisely controllable operation is to be ensured with simple structural means, in particular in the case of use of wear-free diaphragm pumps.

A method of predicting an adverse event in a patient having an implantable blood pump including correlating a pulsatility value to a flow trough value associated with the blood pump to determine a flow peak value; dividing the determined flow peak value by a pump current to determine a pulsatility peak value; tracking a first moving average of the pulsatility peak value, the first moving average defining a threshold range; tracking a second moving average of the pulsatility peak value, the second moving average being faster than the first moving average; and generating an alert when the second moving average deviates from the threshold range.

Disclosed herein is an inflow cannula for an implantable blood pump assembly. The inflow cannula includes a tubular body that extends from a proximal end to a distal end. The tubular body includes a proximal portion adapted for connection to a pump housing, and a distal portion adapted for positioning within an opening formed in a heart. The inflow cannula further includes an expandable sleeve coupled to an exterior surface of the distal portion. The sleeve has a first portion coupled to the distal portion of the tubular body, and a second portion extending from the distal end of the tubular body. The second portion is deployable from a first, stored configuration to a second, deployed configuration in which the second portion expands radially to engage and conform to an endocardial surface of the heart.

A method of detecting hypertension in a patient having an implantable blood pump, the method includes operating the implantable blood pump at a first pump set speed during a first period of time. A first flow rate minimum during a cardiac cycle of the patient is measured during the first period of time. The first pump set speed is reduced by at least 200 rpm during a second period of time after the first period of time to a second pump set speed, the second period of time being less than the first period of time. A second flow rate minimum is measured during a cardiac cycle during the second period of time. If the second flow rate minimum decreases during the second period of time at the second pump set speed by more than a predetermined amount, an alert is generated indicating a presence of hypertension.

A device for reducing pressure within a lumen includes a reservoir structured for holding a fluid therein, an injection port in fluid communication with the reservoir, a compliant body structured to expand and contract upon changes in pressure, and a conduit extending between and fluidly coupling the reservoir and the compliant body. The fluid may be a compressible or a noncompressible fluid.

A cardiac assistance system is provided that comprises two pumps and cannulae connected thereto. A first pump of the two pumps is configured to connect to a right heart system via a first fluid channel. The first fluid channel formed at least partially by a first two cannulae of the cannulae. A second pump of the two pumps is configured to connect to a left heart system via a second fluid channel. The second fluid channel formed at least partially by a second two of the cannulae. The two pumps are configured as rotary pumps for arrangement outside a patient's body.