The invention relates to a system for storing and distributing a gaseous mixture formed of NO/N.sub.2, comprising a container (6) containing an NO/nitrogen mixture equipped with an in-built pressure regulator (8) with an internal passage (22) for gas made of stainless steel and means for regulating the expansion of the gas collaborating with an expansion valve (27) and a valve seat (28) made of stainless steel. A first outlet coupling (21a) referred to as a ‘pressure’ outlet delivers the gas at low pressure and a second outlet coupling (21b) associated with a flow meter device comprising calibrated orifices and a flow rate selection member delivers the gas at several different flow rates. The invention also relates to an installation for distributing a gas containing NO to a patient comprising a ventilator (1) delivering a gas containing oxygen and to a system for storing and distributing a gaseous mixture formed of NO/N.sub.2 according to the invention.

Disclosed is a computer controlled dosage system, for dosage adjustment for a mobile, hand held, inhaler for delivering a dosage of a medicine, is provided. The system comprises at least one measuring device for measuring at least one parameter; and a handheld mobile computer separate from the inhaler, the computer being configured to communicate with the at least one measuring device and with a remote memory for sending and receiving information to and from patient medical records of the remote memory for storage in a memory of the computer, and the computer being configured to receive a manual input for storage in the memory of the computer. The computer is configured to create a data set for setting a plurality of levels of different dosages of medicine based on the medicine used by the inhaler, the information from the patient's medical records of the remote memory, and the manual input; and the computer is further configured to store the data set in the memory of the computer. The computer is further configured to generate an indication indicating a dosage adjustment for the inhaler, based on the at least one parameter and on one of the plurality of levels of dosage of the data set, the indication indicating one of the plurality of levels of dosage of the data set as the dosage adjustment for the inhaler. A dosage regime generated by the computer controlled dosage system is also disclosed.

A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed.

The present disclosure relates to a transportable device for providing a cooled, oxygen-containing gas flow for supplying to a body of mammal via the respiratory tract, in particular a human being, in order to lower the body temperature. The device comprises a storage device comprising at least one fluid reservoir and at least one heat exchanger, wherein the storage device is designed to store an oxygen-containing fluid in the fluid reservoir and for providing a discharge flow of the oxygen-containing fluid. The heat exchanger is designed to cool the provided discharge flow by transferring heat to a cooling stream of a stored fluid and provided by the storage device, and a cooled, oxygen-containing gas flow for supplying to the body emerges from the heat exchanger.

The embodied invention is a new inspiration/expiration ventilator flow design, with a constant inspiration flow and intermittent-concurrent expiratory flow based on lung pressure setpoints. This mode is possible by using a new dual lumen tube inserted into a patient Trachea. Additionally, the control provides support for patient initiated breathing which is initiated by a lung pressure drop. This control provides continuous and gentle recruitment of lung alveoli.

The embodied invention is a new inspiration/expiration ventilator flow design, with a constant inspiration flow and intermittent-concurrent expiratory flow based on lung pressure setpoints. This mode is possible by using a new dual lumen tube inserted into a patient Trachea. Additionally, the control provides support for patient initiated breathing which is initiated by a lung pressure drop. This control provides continuous and gentle recruitment of lung alveoli.

Refreshing stylets, catheter systems, and methods thereof are disclosed. The refreshing stylet can be configured to fit within a lumen of a catheter such as hemodialysis catheter. The refreshing stylet can include an elongated hollow body having a proximal portion coupled to a needleless connector, a distal portion ending in a distal tip, an interior surface, an exterior surface, and a side hole. The exterior surface can be coated with a sustained-release formulation including one or more anti-thrombotic agents. The sustained-release formulation can be configured to contact a luminal surface of the catheter and prevent thrombus formation thereon. The side hole can be configured to provide a locking solution to the lumen of the catheter for locking the catheter between uses.

System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.