Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor.

Medical gas delivery devices are provided. A garment or another object may include a hose assembly configured to couple the garment or the object to a medical gas source. The garment or the object can be configured to deliver a medical gas to a patient. Additionally, medical gas delivery devices configured to be removably coupled to a garment or another object are provided.

Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.

Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.

An additive gas delivery apparatus for delivery of additive gas to inspirational gas can be set to deliver the additive gas according to a dosing setting in normal therapy, and can be set to deliver according to a backup dosing setting in response disruption of signals representing data for controlling the delivery of additive gas according to the dosing setting in normal therapy. An additive gas delivery apparatus has an inlet for the additive gas and an integrated inlet for gas for oxygenating the patient that are connected to a backup line to mix the additive gas and gas for oxygenating the patient to a set concentration of additive gas in the gas mixture at an integrated backup outlet of the additive gas delivery apparatus.

The disclosure concerns various devices implemented to provide a therapeutic gas rich environment to promote healing, reduce fibrosis and scar formations while maintaining anti-inflammatory, anti-thrombotic, antimicrobial, and vasodilating properties. The device generally includes a gas-donor composition that is embedded within a fibrous holding layer. Coupled to one side of the fibrous holding layer is a water-permeable layer and coupled to an opposite side of the fibrous holding layer is a gas-permeable layer. The water-permeable layer is configured to receive and communicate water to the gas-donor composition, wherein upon contact with the water, the gas-donor composition is configured to deliver a therapeutic gas through the gas-permeable layer to a treatment site of a subject.

Start-up protocols for a device and method for administering NO is described.

Start-up protocols for a device and method for administering NO is described.

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.

A method of determining a duration of safe apnoea. Information is obtained relating to a respiratory indicator, and a duration of safe apnoea is determined from the obtained information. A respiratory therapy system has one or more patient interfaces. A processor is configured to determine a duration of safe apnoea based on obtained information relating to a respiratory indicator.