Drug delivery devices (200) and methods of their use are provided. In one embodiment, a drug delivery device (200) for use with a urinary catheter (100) includes a drug reservoir configured to be disposed outside of a patients body, and a flexible elongate body (220) attached to the drug reservoir (230) and configured to traverse the patients urethra to reach the bladder. The drug reservoir (230) includes a drug chamber (234) containing a drug therein, a fluid chamber (236) containing a fluid therein, and an osmotic barrier (238) separating the drug chamber (234) and the fluid chamber (236). The body includes a drug delivery lumen (222) extending therethrough and in fluid communication with the drug chamber (234).

Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches.

Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches.

Trans-activating transcription (TAT) factor peptide oligomers coupled with functional agents can selectively complex to the anionic surface of cancerous cells. The TAT conjugates can be delivered to the locus of the tumors using intra-arterial injection during transient blood flow arrest.

An anesthesiology pump for automatic delivery and control of anesthetics to a patient provides a remote unit that may be carried by an anesthesiologist to improve supervision of the anesthesiology process without unnecessarily constraining the anesthesiologist's movement. The anesthesiology pump may assess one or both of a status of the anesthesiology procedure and the availability of the anesthesiologist to provide tailored alerts to the anesthesiologist when additional attention or availability may be needed. Availability may consider separation distance between the pump and the radiologist as well as express indications of availability. A set of predefined safe states permit a pump response when the anesthesiologist is not available and additional attention is required.

An adductor canal block introducer for introducing a catheter and also administering an initial dose of local anesthetic. The adductor canal block introducer generally includes a cannula having an elongated body with a distal end, a proximal end, and a slot extending along the elongated body, the slot having two sides and a lower surface. It also includes a cannulated trocar positioned in the slot of the cannula, the cannulated trocar having a distal end and a proximal end, wherein the trocar includes a discharge proximate to the distal end, wherein an inlet and the discharge are in fluid communication with each other. The introducer also includes a catheter positioned in the slot, held in place by the cannulated trocar. The catheter may also be positioned by a grasper introducer that holds the catheter and also includes a discharge at its distal end through which an anesthetic can be administered.

A nerve block introducer for introducing a catheter and also administering an initial dose of local anesthetic, the introducer having an elongated body with a distal end and a proximal end, an inlet, and at least one discharge opening for the local anesthetic near the distal end. The introducer also includes a grasping member near the distal end of the elongated body, the grasping member operably coupled to a handle near the proximal end of the elongated body such that the grasping member can be used to releasably hold a catheter by operation of the handle. The catheter may thus be positioned and left in place following removal of the introducer.

A method and an apparatus for applying an anesthetic that includes a receptacle having an upper end, a substantially hollow interior, a lower end having a tube or nozzle extending therefrom, and an attachment for attaching to the barrel of a syringe or vice versa. The receptacle receives a container or canister containing an endothermic gas or vapor (propellant) that rapidly absorbs heat when released to the atmosphere. A depressible actuating member or trigger propels the gas or vapor through an outlet nozzle that is oriented to project a stream of gas or vapor along a delivery axis that intersects a delivery axis of the needle, therefore, the gas or vapor can be successively delivered to an injection site with minimal repositioning of the housing.

Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches.

Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches.