The present invention provides a delivery device for intranasal administration of topical therapeutic agents to a desired site within a nasal cavity. The delivery device, in some embodiments, comprises a housing defining an interior and adapted to contain a supply of at least one therapeutic agent. The delivery device further includes a flexible connector, which is in fluid communication with the supply in the housing. A distributor, which is also integrally formed with the connector, is also provided. The distributor includes a proximal end that is in fluid communication with a distal end of the connector, and is adapted to receive the supply of the at least one therapeutic agent delivered by way of a conduit. The distributor further includes a distal end defining an outlet configured to diffuse the therapeutic agent when delivered to the treatment site.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include at least one toxin removal system configured to process blood from at least two places on the patient's body at a rate, for example, of at least 0.5 liters per minute. The system may be configured to raise the pH level of the patient's blood by introducing a fluid at rate of at least 9 liters per hour.

A mechanical infusion pump device for injecting medication into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger which is moved in a first direction against a mechanical biasing element by engagement with a manually operable, independently movable filling plunger to fill the syringe with fluid medication. The mechanical biasing element is provided for exerting bias on the syringe plunger in a second syringe-discharging direction to dispense medication from the syringe into the patient's IV when the filling plunger is released. Only a calibrated amount of medicine can be discharged to the patent's IV over time as determined by calibration of the biasing element and a metering element located between the syringe and the patient's IV for a given viscosity of the medication.

A nozzle apparatus for dispensing an adjustable combination of gas, having a nozzle outlet adjustably combined with a delivery component. The nozzle outlet may have a groove for receiving a roll pin; and an inner lumen comprising a cylindrical shaft having a diameter between 5/1000ths and 20/1000ths of an inch. The delivery component configured to receive air from the nozzle outlet, may have a first circular ambient air hole having a diameter, and a second circular ambient air hole having the same diameter as the first ambient air hole, and a removable plugging device covering the second circular ambient air hole. The delivery component may be adjustable in orientation with respect to the nozzle outlet, and may be adjustable to vary a concentration of therapeutic gas delivered to a patient.

An anesthesiology pump for automatic delivery and control of anesthetics to a patient provides a remote unit that may be carried by an anesthesiologist to improve supervision of the anesthesiology process without unnecessarily constraining the anesthesiologist's movement. The anesthesiology pump may assess one or both of a status of the anesthesiology procedure and the availability of the anesthesiologist to provide tailored alerts to the anesthesiologist when additional attention or availability may be needed. Availability may consider separation distance between the pump and the radiologist as well as express indications of availability. A set of predefined safe states permit a pump response when the anesthesiologist is not available and additional attention is required.

Devices, systems, and methods for treating chronic rhinosinutisits (CRS) are described herein. The devices can have a guide member defining at least one lumen therethrough. A drug delivery component is advanced through the lumen to deliver a substance to the sino-nasal cavity of a patient. Once the drug delivery component is positioned at the desired area in the sino-nasal cavity, a user actuates the system to deliver the substance to the target area. Actuation of the system delivers the substance to the middle meatus, osteo-meatal complex, or other areas within the sino-nasal cavity of the patient.

A neuromuscular test device for assessing a level of neuromuscular blocking agents (NMBAs) in an anesthetized patient includes a stimulation circuit for initiating a muscular stimulus in a muscle structure, and a testing circuit for measuring an activity level responsive to the muscular stimulus. A flexible, closed vessel is responsive to a musculature response for inducing a pressure, and a pressure sensor in communication with the closed vessel generates a pressure signal indicative of the musculature response to the muscular stimulus.

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

In an example, a method for delivering an anesthetic agent to a target tissue in a nasal cavity of a patient includes inserting a cryotherapy device into the nasal cavity of the patient. The cryotherapy device includes a cryotherapy delivery feature and one or more protrusions. The method also includes positioning the cryotherapy delivery feature in contact with the target tissue, and delivering, using the cryotherapy delivery feature, a cryotherapy treatment to the target tissue. After inserting the cryotherapy device into the nasal cavity, the method includes actuating the one or more protrusions from a retracted state to an extended state. After actuating the one or more protrusions to the extended state, the method includes penetrating the target tissue with the one or more protrusions. After penetrating the target tissue, the method includes delivering, via the one or more protrusions, an anesthetic agent into the target tissue.

The present invention describes a method for performing a prostate surgical treatment, said method comprising: arranging a catheter 1 inside of a urethra of a patient and anchored against the bladder neck of the patient subsequent to the filling of the balloon stopper unit 5 with a fluid when the balloon stopper unit 5 is arranged inside of the bladder of a patient;
said method also comprising injecting at least one anesthetic agent and adrenaline or injecting botulinum toxin (Botox) and/or penicillin to the prostate via the injection tube 9 and the hollow tip 10 at an intended position of the prostate.

Moreover, the present invention also refers to a kit comprising a catheter 1 according to the present invention and one or more syringe(s) 1000 containing adrenaline and at least one anesthetic agent and/or at least a syringe 1000 or vial containing botulinum toxin (Botox) and/or penicillin.