Disclosed herein is a method of removing fluid from a subject, using the steps of (i) administering a first hypertonic solution comprising a sugar-based osmotic agent to a peritoneal cavity in the subject; (ii) allowing water from the subject to pass into the peritoneal cavity by osmosis, thereby forming a second hypertonic solution within the peritoneal cavity, the second hypertonic solution having a lower concentration of the sugar-based osmotic agent than the first hypertonic solution; (iii) withdrawing a portion of the second hypertonic solution from the peritoneal cavity and combining the withdrawn second hypertonic solution with a sugar concentrate to form a third hypertonic solution; (iv) administering the third hypertonic solution to the peritoneal cavity to form a fourth hypertonic solution within the peritoneal cavity by mixing of the second and third hypertonic solutions; and (v) repeating steps (ii) to (iv) for a desired treatment time. Also disclosed herein is an apparatus suitable for use with the method.

Pump subsystem for fluid delivery (e.g., in a wearable patch pump) comprises a fluid chamber with pumping motion and a valve shaft assembly with valving motion, both being driven by the same drive mechanism. Fluid chamber has variable volume chamber provided by a piston driven by the drive mechanism and translated relative to a plug in the pump housing. Piston extends the fluid chamber during an intake stroke and retracts the fluid chamber during a discharge stroke. Valve assembly has at least one valve shaft controllably translated by the drive mechanism to selectively align a first throughway with an opening in the pump chamber and a fluid intake port for an intake stroke to draw fluid into the fluid chamber, and align a second throughway with the opening in the pump chamber and a fluid discharge port for an discharge stroke to discharge fluid from the fluid chamber.

Provided is a medical liquid injection device including a base body, a needle assembly mounted on the base body, a reservoir fluidly connected to the needle assembly and having an inner space in which a medical liquid is stored, a plunger disposed inside the reservoir, and configured to move in a longitudinal direction of the reservoir according to an amount of the medical liquid stored in the reservoir, and a first sensor unit configured to measure the amount of the medical liquid stored in the reservoir according to the movement of the plunger.

A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.

A pump subsystem for fluid delivery (e.g., in a wearable patch pump) is provided wherein pumping action is generated by linear piston movement that pulls a plug, which is interconnected to the piston between two mechanical extremes or end stops in a telescopic or variable volume fluid chamber. Such interconnection enables piston and plug to move a certain distance with respect to each other that corresponds to a predefined swept volume of the pump subsystem. Telescoping-like effect of relative piston and plug movement provides for intake and discharge of fluid with respect to the fluid chamber. Movement of plug within piston can be enabled by the friction of seals placed on the plug, which serve to provide resistance to piston motion and therefore force translation motion of the plug to lag relative to the piston translation motion during portions of the pump cycle.

Provided is a medical liquid injection device including a base body, a needle assembly mounted on the base body, a reservoir fluidly connected to the needle assembly and having an inner space in which a medical liquid is stored, a plunger disposed inside the reservoir, and configured to move in a longitudinal direction of the reservoir according to an amount of the medical liquid stored in the reservoir, and a first sensor unit configured to measure the amount of the medical liquid stored in the reservoir according to the movement of the plunger.