The present invention relates to an apparatus for performing an automated peritoneal dialysis treatment on a patient, the apparatus comprising: a first dialysis fluid port for receiving a first dialysis fluid having a first composition, which is determined by the concentrations of a set of first dialysis fluid constituents; a dialysis fluid line system connecting the first dialysis fluid port to a patient terminal; at least one dialysis fluid pump acting on the dialysis fluid line system and configured to convey the first dialysis fluid from the first dialysis fluid port to the patient terminal; and a control unit operably connected to the at least one pump; wherein the apparatus further comprises a second dialysis fluid port for receiving a second dialysis fluid having a second composition, which is determined by the concentrations of a set of second dialysis fluid constituents. The invention further relates to a system for automated peritoneal dialysis treatment and a data carrier comprising controlling software for such apparatus or system.

Apparatus and methods calculate and deliver doses of insulin and optionally glucagon into a subject. Online operation controls delivery of correction doses of insulin automatically in response to regular glucose measurements from a sensor, and offline operation calculates and delivers correction doses based on isolated glucose measurements and information gathered autonomously during preceding online operation. In another aspect, offline operation includes automatically calculating and administering meal doses based on information gathered autonomously during preceding periods of online operation. Both methods include generating relevant control parameters tailored to the individual and continually converged upon and potentially modulated during online operation. The control parameters are employed in real time during periods of offline operation to regulate glucose level without the need for user-provided control parameters such as correction factors and insulin-to-carbohydrate ratios.

The invention relates to a device for treating an individual suffering from cardiac or circulatory arrest or from a stroke, comprising a blood withdrawal device (BE) that is applied to the individual (P), an analysis unit (BA) which is directly or indirectly connected to the blood withdrawal device for detecting a blood analysis result (BAE) providing at least one characteristic of the blood, directly or indirectly connected to a blood return device (BR) that is applied to the individual (P) and is designed to deliver a substance to the individual via the return device (BR).

An apparatus used in analyzing spent dialysate includes: at least one surface configured to accommodate a dialysate drain bag or drain line in a predetermined position; a light source positioned to emit light through the dialysate drain bag or drain line; and a light sensor positioned to sense light emitted by the light source through the dialysate drain bag or drain line.

An interlocking drug infusion device includes a drug reservoir, used for accommodating the drug to be infused, provided with a piston and a screw; a driving wheel, connected with the screw, driving the screw to push the piston forward by rotation; a driving unit, the driving unit moved in a driving direction to drive the driving wheel to rotate; an actuator, electrically connected to the driving unit, used to provide power for the driving unit in the driving direction after energized; a program module, electrically connected to the actuator, the program module providing a first driving instruction for controlling the actuator to perform periodic power output; and a position detection module, used to determine the periodic drug infusion amount. When the drug infusion amount reaches a preset threshold, the position detection module and/or the program module provide the actuator with a second driving instruction.

The present invention concerns a package comprising an acidic citrate containing concentrate, an acidic citrate containing concentrate (or acidic citrate containing solution), and a system wherein the acidic citrate containing concentrate is included for providing a dialysis treatment. The acidic citrate containing concentrate contains citric acid and citrate in a molar ratio of 75:25 to 85:15, and has a pH of between 2 and 3.

A pen cap for a medication delivery pen includes a piston-style detector mechanism. The piston-style detector mechanism includes at least an inner shell having first open end through which the medication delivery pen can be inserted, a second end opposite the first end, a sidewall defined by an outer surface and an opposing inner surface, and a passageway extending from the outer surface to the inner surface. The sidewall extends between the first end and the second end thereby defining a pen-receiving cavity there between. The piston-style detector mechanism further includes at least one switch and a translatable shaft at least partially disposed in the passage. The translatable shaft includes a body that extends at least from a pen-interfacing portion in the pen-receiving cavity to a switch-interfacing portion thereof. The translatable shaft is oriented to travel from a first location to at least a second location during capping of a medical delivery pen into the inner shell to toggle the at least one switch.

A sampling system performs an automatic dialysis sampling at specific time intervals of a dialysis treatment. The system includes a fluidic pathway in which a dialysis solution flows, a series of sampling containers, and a valve system. The valve system is arranged in the fluidic pathway. The sampling system includes an electronic system that controls automatically the valve system in order to direct a certain quantity of each fluid sample to a specific sampling container.

In some embodiments, an infusion device can include a reservoir configured to hold a medicament, a first epicyclic gear arrangement comprising a first output, a second epicyclic gear arrangement comprising a second output, a first trocar coupled to the first output and movably coupled to a sensor electrode, and a second trocar coupled to the second output and movably coupled to an infusion cannula that is fluidically coupled to the reservoir. Actuation of the first epicyclic gear arrangement can drive linear travel of the first trocar and/or the sensor electrode, and actuation of the second epicyclic gear arrangement can drive linear travel of the second trocar and/or the infusion cannula.

The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler.