Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

An aerosol delivery system that includes an aerosol generator that aerosolizes a fluid for delivery to a patient. The aerosol generator includes a housing with a fluid chamber that fluidly communicates with a housing inlet and a housing outlet. Within the housing, the aerosol generator includes a support plate with an aperture that fluidly communicates with the housing outlet. A vibratable member couples to the support plate across the aperture. A piezoelectric actuator also couples to the support plate, and in operation expands and contracts to vibrate the vibratable member, which aerosolizes a fluid. The aerosol generator receives fluid through a fluid conduit that couples to the housing.

This assembly for tracheal instillation of fluid medicaments, particularly in preterm infants supported by non-invasive ventilation, comprises a microcatheter, a guidewire and a gripper. The microcatheter consists of a very small gauge soft composite tube with a proximal connector and a distal rounded tip. Three circumferential color-coded bands near the rounded tip and a scale in one-centimeter increments on the soft composite tube guide the insertion depth positioning of the rounded tip under direct laryngoscopy. The slidably receptive guidewire within the central lumen of the microcatheter stiffens the soft composite tube for introduction and restores softness thereto after removal. Additionally, the guidewire is locked to the microcatheter during the introduction into the trachea to avoid injury. A gripper attached to the soft composite tube improves manipulation as well as estimated insertion depth control. Once the guidewire is removed, the fluid agent (e.g. surfactant) is slowly instilled into the neonatal trachea.

An adaptor for a respiratory assistance system delivers aerosols to a patient. The adaptor is lightweight with a small footprint to increase patient comfort. The adaptor has a nozzle and a sealing mechanism to maintain pressure therein regardless of whether the nozzle is inserted into the adaptor. The adaptor is configured to connect to medical tubing and a medicament delivery device.

A laryngeal mask airway device includes an airway tube and a laryngeal mask placed at a distal end of the airway tube. The distal end of the airway tube opens inside the laryngeal mask. The device includes a connector placed at a proximal end of the airway tube. The connector is in fluid communication with the laryngeal mask through the airway tube and is configured to be connected to a ventilation equipment. The device includes a movable element placed in the laryngeal mask and configured to steer a tip of a catheter passing through the airway tube. The device further includes a control element mounted on the proximal end of the airway tube and a motion transmission device operatively connected to the movable element and to the control element to move the movable element and to steer the tip of the catheter by acting on the control element.

A laryngeal mask airway device includes an airway tube and a laryngeal mask placed at a distal end of the airway tube. The distal end of the airway tube opens inside the laryngeal mask. The device includes a connector placed at a proximal end of the airway tube. The connector is in fluid communication with the laryngeal mask through the airway tube and is configured to be connected to a ventilation equipment. The device includes a movable element placed in the laryngeal mask and configured to steer a tip of a catheter passing through the airway tube. The device further includes a control element mounted on the proximal end of the airway tube and a motion transmission device operatively connected to the movable element and to the control element to move the movable element and to steer the tip of the catheter by acting on the control element.

A system of treating atelectasis is provided that includes a tracheal tube positioned within an airway of a ventilated patient and an acoustic sensor coupled to the tracheal tube. The system also includes a monitor communicatively coupled to the acoustic sensor. The monitor includes a processor configured to receive a baseline signal from the acoustic sensor. The processor is configured to provide control instructions to adjust a pressure of a gas mixture delivered to the airway through the tracheal tube. The processor is also configured to receive an updated signal from the acoustic sensor after the adjustment and identify a change in airway openness of lungs of the ventilated patient caused by the adjustment of the pressure. Further, identifying the change is based on the baseline signal and the updated signal.

A system of treating atelectasis is provided that includes a tracheal tube positioned within an airway of a ventilated patient and an acoustic sensor coupled to the tracheal tube. The system also includes a monitor communicatively coupled to the acoustic sensor. The monitor includes a processor configured to receive a baseline signal from the acoustic sensor. The processor is configured to provide control instructions to adjust a pressure of a gas mixture delivered to the airway through the tracheal tube. The processor is also configured to receive an updated signal from the acoustic sensor after the adjustment and identify a change in airway openness of lungs of the ventilated patient caused by the adjustment of the pressure. Further, identifying the change is based on the baseline signal and the updated signal.

A neonatal laryngeal mask airway (NLMA) can be used for airway management in the neonate in emergent situations, e.g., respiratory distress syndrome after premature birth, and nonemergent situations, e.g., elective surgery. The NLMA includes a back plate and a cuff. The back plate provides a shelf, a back plate opening, and a wall, which is perpendicular to the shelf, that surrounds a portion of the back plate opening. The cuff is coupled completely around a perimeter of the back plate. The cuff is configured for inflation from an uninflated state to an inflated state in a patient with a pharynx, a larynx with a laryngeal inlet, and a trachea. In the inflated state, the cuff forms a seal around the laryngeal inlet to isolate the larynx from the pharynx, and the back plate is configured to guide a catheter inserted through the back plate opening into the trachea.

The invention relates to a humidifier configured to humidify an aerosol, the humidifier comprising a first water compartment (100) containing water used to humidify the aerosol; a second water compartment (300) containing water used to humidify the aerosol; an intermediate chamber (200) located between the first and the second water compartment (100, 300), the intermediate chamber (200) comprising an aerosol inlet (210) and an aerosol outlet (220) and providing first boundary surfaces of a passageway (230) through which the aerosol to be humidified passes; a first layer (10) permeable to water vapour and impermeable to liquid water, which is located between the first water compartment (100) and the intermediate chamber (200), wherein a section of the first layer provides a second boundary surface of the passageway; a second layer (20) permeable to water vapour and impermeable to liquid water, which is located between the second water compartment (300) and the intermediate chamber (200), wherein a section of the second layer provides a third boundary surface of the passageway (230) opposed to the second boundary surface.