There is provided an infusion device for subcutaneous infusion of a therapeutic agent. The infusion device may comprise a cannula for insertion into a patient, and a filter disposed within the cannula, the filter comprising a filter material having a plurality of passageways extending therethrough to allow fluid flow through the filter and thereby through the cannula. The infusion device may have application in infusion pump systems such as an infusion pump for delivery of an insulin drug, the infusion pump system comprising a fluid pump and a reservoir, and an infusion set comprising the cannula and tubing for connecting the cannula to the reservoir.

A cannula for subcutaneous infusion of a therapeutic agent, an infusion device for subcutaneous delivery of a therapeutic agent to a patient comprising the cannula, and a method of administering a therapeutic agent via an infusion device, the cannula comprising a tubular body member comprising a tubular wall at least partly enclosing a longitudinal extending internal bore, a distal portion of the tubular body member having a distal tip end, wherein the distal portion comprises a weakened section comprising a first plurality of holes and a second plurality of holes, the weakened section being capable of allowing the cannula to flex in an area comprising the weakened section when the cannula is exposed to a compression force and/or an increased internal pressure, and wherein the first plurality of holes comprise holes of larger diameter than the second plurality of holes.

Circulating cell clusters found in subjects with cancer, autoimmune conditions, infections, or other diseases, can be trapped or disrupted by filtering them with an intra- or extracorporeal device and, in some cases, exposing them to a substance, such as enzyme, that reduces intercellular adhesion.

A highly-removable microneedle structure, a microneedle device including the same, and a method for manufacturing the structure are disclosed. The highly-removable microneedle structure includes: a tip tapered downwardly; a base extending upwardly from an upper surface of the tip and having an area size in a plan view thereof smaller than an area size in a plan view of an upper surface of the tip; and a tube surrounding the base and extending upwardly from the upper surface of the tip and beyond an upper surface of the base.

A device for providing fluid access to a mammals central nervous system comprising: a fluid port allowing the fluid access; a housing comprising an extracorporeal portion and a lowermost surface to engage with the skull; and a fluid tube connected to the fluid port and extending below the housing. In various aspects: no part of the housing extends below the lowermost surface and the fluid tube bends to run along a trench in the skull; the lowermost surface comprises teeth; a septum seals the fluid port and a cap engages with the extracorporeal portion to compress the septum; and the device comprises a guide member and a connector having needles for fluid connection via the fluid port engages with the guide member, where, upon engagement of the connector and guide member, the needles adopt predetermined positions. Also provided is a method of implanting the device.

Provided are a driving mechanism and a blood pump. The driving mechanism comprises a housing, a rotating shaft, a rotor, a first shaft sleeve, a second shaft sleeve, and a stopping member. The rotating shaft is rotatably mounted on the housing. The rotating shaft has a connecting end and a ball head end away from the connecting end. The connecting end is configured to be connected to an impeller. The rotor is fixedly connected to the rotating shaft. The first shaft sleeve is provided with a groove. The rotating shaft is rotatably arranged on the second shaft sleeve in a penetrating manner. The ball head end is movably arranged in the groove. The stopping member is fixedly connected to at least one of the rotating shaft and the rotor. The stopping member can abut against the second shaft sleeve.

Circulating cell clusters found in subjects with cancer, autoimmune conditions, infections, or other diseases, can be trapped or disrupted by filtering them with an intra- or extracorporeal device and, in some cases, exposing them to a substance, such as enzyme, that reduces intercellular adhesion.

An intra-ruminal device including a cap, with outlet, that overlaps a portion of a barrel to define an attachment zone. Located within the attachment zone is at least one protrusion providing a localised point of contact between the barrel wall and the internal sidewall of the cap to provide for an ultrasonic weld between the barrel and the cap. Optionally the device includes a plunger, and the plunger optionally includes at least one aperture to allow fluid or gas communication between first and second compartments in the barrel. Optionally included are at least one pair of resilient wings, the wings having a pair of reinforcement ridge that extend a first distance from the body along the wing surface, and at least one middle reinforcement ridge that extends between the pair of ridges from the body a second distance, and where the second distance is less than the first distance.

Circulating cell clusters found in subjects with cancer, autoimmune conditions, infections, or other diseases, can be trapped or disrupted by filtering them with an intra- or extracorporeal device and, in some cases, exposing them to a substance, such as enzyme, that reduces intercellular adhesion.

An intra-ruminal device of a Laby-style design that includes a cap having a sidewall and top, the cap located over the barrel opening and including an outlet in the top; and a variable geometry device defined by at least one pair of resilient wings extending outwardly from the end of the body distal to the first end, each pair of wings having a pair of reinforcement ridge that extend a first distance from the body along the wing surface, and at least one middle reinforcement ridge that extends between the pair of ridges from the body a second distance, and where the second distance is less than the first distance.