An Ultrasound Transmission Gel Packet Having Internal Heat Source and Method of Use. The gel packet is sized for a single use, rather than for multiple applications. The gel packets are not pre-heated, but rather are quickly heatable on demand. The gel packets may incorporate a variety of optional internal heating methods, including chemical activation, mechanical agitation and electrical activation, among others. The gel packets are sealed and therefore have extended shelf lives, and further are disposable after use.

The present invention relates to a pulsatile positive-displacement pump with a flexible positive-displacement diaphragm which is operated pneumatically and by whose movement the blood is aspirated and displaced. A mechanical switching device in the interior of a drive unit ensures an autonomous operation of the blood pump, wherein no electricity or electronics system is needed.

A wound therapy system according to an example of the present disclosure includes a wound therapy that has a porous body operable to carry a fluid from a wound site, a tube, and a pump connected to the porous body by the tube. The pump is operable to apply vacuum through the tube to draw fluid from the wound site.

A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Devices, systems, and methods for detecting a sealing condition between a patient interface and a patient, and adjusting the patient interface to maintain the patient interface in sealing contact with the patient. The patient interface may include a sealing structure to form a seal on the patient, and a positioning structure to secure the sealing structure to the patient. The patient interface may include a sensor coupled to the sealing structure. A processor determines the sealing condition between the sealing structure and the patient based on a signal from the sensor, and adjusts at least one of the sealing structure and the positioning structure to maintain the sealing structure in sealing contact with the patient. A prediction system predicts a leak between the sealing structure and the patient based on the sensor signal. A learning system learns how to fit the sealing structure to the patient to form a seal.

The present disclosure relates to aerosol delivery devices. In various implementations, the aerosol delivery devices comprise a control device that includes a battery, a control component, and an outer housing that defines receiving chamber, and a cartridge that includes a mouthpiece portion, a tank that contains a liquid composition, and a heater configured to heat the liquid composition. The cartridge and the control device each include at least one connector configured to provide a magnetic and an electrical connection between the cartridge and the control device such that the cartridge can be removably and operatively received into the cartridge receiving chamber of the control body, wherein the at least one connector of the cartridge is located on the mouthpiece portion.

A fully implantable intracorporeal blood purifier for patients with impaired, missing, or normal kidneys overwhelmed by a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia, primary myelofibrosis, or chronic myelogenous leukemia. Functioning continuously or intermittently around the clock, the patient is spared the need to visit the clinic as frequently for treatment, and less severe renal dysfunction may allow the intervals between visits to be considerably extended if not eliminated. The intracorporeal blood purifier represents the extractive or negative component in a prosthetic disorder response system of which the positive component detects the need for and releases medication such as tyrosine-kinase inhibitorsimatinib, and interferon alfa-2b, and cooperates with the purifier to accomplish kidney functions not simply extractive, such as releasing hormones, calcitriol, sodium, and potassium into the blood, maintaining electrolyte, acid-base, and fluid balance, and furnishing small molecule amino acids and glucose by directly targeting the gut.

Disclosed are a fluid drainage devices and methods of use for drainage of edematous tissues of a patient. The devices include an inlet catheter comprising a plurality of lumens configured to receive fluid from the edematous tissues, wherein the plurality of lumens run axially parallel in the inlet catheter; an outlet catheter configured to be anchored at a sink; an implantable pump coupled to the inlet catheter and the outlet catheter, the pump having a rotating portion including a permanent magnet, the rotating portion configured to rotate in response to a magnetic force external to the patient to move fluid from the inlet of the inlet catheter to the second end of the outlet catheter; and an external controller configured to transcutaneously couple to the permanent magnet of the rotating portion to apply the magnetic force to the implantable pump.

Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).