A method for the fail-safe termination of in vivo drug delivery from an implantable drug delivery system, the method comprising: providing an implantable drug delivery system comprising: a housing having a reservoir for containing a drug, and a port for dispensing the drug to a patient; and an emergency deactivation unit disposed between the reservoir and the port, the emergency deactivation unit comprising a composite structure comprising a biocompatible ferromagnetic mesh open to fluid flow and a hydrophobic meltable material, the hydrophobic meltable material comprising at least one hole therein for enabling a fluid to pass through the hydrophobic meltable material; implanting the implantable drug delivery system within a patient; enabling the drug to flow from the reservoir, through the at least one hole in the hydrophobic meltable material and out the port; and when drug flow is to be terminated, applying a magnetic field to the composite structure, such that a current is induced in the ferromagnetic mesh which heats the ferromagnetic mesh and melts the hydrophobic meltable material, thereby closing the at least one hole in the hydrophobic meltable material and blocking drug delivery to the patient.

Systems and methods for assembling a plurality of tissue grafts are provided. A method includes applying a magnetic coating over a surface of a donor site and harvesting the plurality of micro tissue grafts from the donor site, so that an upper surface of each of the plurality of micro tissue grafts contains the coating. The method also includes arranging a magnet over the magnetic coating to induce the plurality of micro tissue grafts to organize in a desired orientation, forming a tissue construct containing the plurality of micro tissue grafts arranged in the desired orientation, and applying the tissue construct to a recipient site.

Described here are devices, systems, and methods for cannulating a vessel. Generally, the method may comprise advancing a stent into a first vessel and deploying the stent in the first vessel to hold open one or more valves. This may permit retrograde blood flow through the blood vessel in peripheral vasculature and aid in cannulation of the blood vessel.

A cover for magnetizing a shaft of a tissue-penetrating medical device is disclosed including a sleeve member having a hollow body to form a protective closure over the shaft of the tissue-penetrating medical device. The open end of the hollow body provides a receiving space for receiving the shaft of the tissue-penetrating medical device. A magnet is disposed on the sleeve member. Medical devices and methods of magnetizing the shaft of a tissue-penetrating medical device using the cover are also disclosed.

The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

The present disclosure provides an aerosol delivery device and a liquid delivery and atomization assembly for use with an aerosol delivery device. In one implementation, the liquid delivery and atomization assembly comprises a liquid composition, an atomization assembly, and a liquid delivery component configured to transport at least a portion of the liquid composition to the atomization assembly. The liquid delivery component comprises at least one microchannel configured to deliver the portion of the liquid composition to the atomization assembly, and the microchannel includes a variable flow characteristic defined along at least a portion of the microchannel, the variable flow characteristic being configured to control the flow of the portion of liquid composition through the microchannel.

According to some embodiments there is provided a device configured for releasing at least one substance from source material, comprising: a housing; a plurality of source material sections positioned at fixed locations with respect to the housing; a plurality of airflow paths, each airflow path associated with at least one source material section; each airflow path associated with at least one blocking element which prevents flow of air through the path; and an actuator operably coupled to the blocking element, the actuator configured for unblocking the airflow path of at least one selected source material section to allow flow of air to and through source material within the selected section.

A system of medical devices includes a first medical device, a second medical device, an RLC circuit, a processor, and an output device. The first medical device includes an elongate member having a lumen. The second medical device includes a needle advanceable through the lumen. The RLC circuit includes an excitation voltage source, a resistor, a capacitor, an inductor, and an output voltage sensor. The inductor includes a coil that is supported by the first medical device and wound around the lumen. As the needle is advanced through the lumen, an output voltage of the RLC circuit is an indicator of a longitudinal position of the needle with respect to the elongate member. The voltage sensor is configured to sense the output voltage, and the processor and output device are configured to generate an output that is an indicator of the longitudinal position of the needle.

The present invention discloses a negative-pressure oral apparatus capable of relieving discomfort of soft tissues in the oral cavity and improving fixation of the oral apparatus to prevent the oral apparatus from falling off due to mouth opening. The oral apparatus is compact and elastic so that it fits various shapes and sizes of the oral cavity and is easy to be put on and taken off to provide convenience and safety to the user. In another embodiment, a method for maintaining a negative oral pressure and collecting liquid by coupling the oral apparatus to a liquid collecting apparatus capable of effectively providing the oral cavity with a negative pressure to expel liquid in the oral apparatus and deliver the liquid to an absorbing element in the liquid collecting apparatus so as to prevent liquid leakage or contamination.

The present disclosure relates to aerosol delivery devices. In various implementations, the aerosol delivery devices comprise a control device that includes a battery, a control component, and an outer housing that defines receiving chamber, and a cartridge that includes a mouthpiece portion, a tank that contains a liquid composition, and a heater configured to heat the liquid composition. The cartridge and the control device each include at least one connector configured to provide a magnetic and an electrical connection between the cartridge and the control device such that the cartridge can be removably and operatively received into the cartridge receiving chamber of the control body, wherein the at least one connector of the cartridge is located on the mouthpiece portion.