A device is provided for delivering one or more substances within at least one body cavity. The device includes at least one pierceable vial comprising V.sub.sub [ml or mg] of the substances; the vial having at least one fluid discharging outlet port, configured for placement in proximity to the body cavity. The pierceable vial is configured to interface in a sealable manner with at least one pressurized fluid at volume V.sub.PF [ml] and pressure P.sub.PF [barg]. The device, upon actuation, permits the pressurized fluid to enter into the pierceable vial via the at least one fluid inlet port, entrains the substances, and delivers the substances through the fluid discharging outlet port to within the body cavity in the form of at least one selected from a group consisting of drops, droplets, stream, aerosol and any combination thereof.

Various exemplary drug delivery devices with a mechanical stop, drug products utilizing the same, and methods of using drug delivery devices with a mechanical stop are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.

Various exemplary drug delivery devices with multiple drug vials, drug products utilizing the same, and methods of using drug delivery devices with multiple drug vials are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom into a nose and includes two or more vials each containing the drug therein. The drug delivery device is configured to deliver the drug from each of the vials for a total of two or more sprays into the nose. The same drug delivery device may therefore deliver multiple drug sprays to a user. In some embodiments, instead of including two or more vials that collectively contain enough drug therein for more than two drug sprays, the drug delivery device can include a single vial that contains enough drug therein for more than two drug sprays.

Negative pressure device for treating and removing fluid from a wound has a housing having a first end connectable to the wound and an opposite second end, wherein the-housing is in a single piece, hollow and cylindrical. A piston slides inside the housing to generate the negative pressure, and a constant-force mechanism is loaded and activates the piston, the constant-force mechanism is fixed to the second end of the housing and to the piston and is placed inside the housing. A valve system draws air from the housing when the piston slides towards the first end and brings fluid into the housing when the piston slides towards the second end. The constant-force mechanism is entirely contained inside the housing, and the piston and the second end of the housing comprise a rear opening such as to allow a user to manually slide the piston and load the constant-force mechanism.

A nasal powder dispenser device (100) having a reservoir (110) containing a dose of powder; a nasal dispenser head (120) for inserting into a user's nostril, the nasal dispenser head including a dispenser orifice (121); and an air expeller (130) that, during actuation of the nasal powder dispenser device (100), generates a flow of compressed air so as to dispense a dose of powder into the nostril through the dispenser orifice (121). The air expeller has an air chamber (131) and a piston (132) that slides in airtight manner in the air chamber (131) so as to compress the air contained in the air chamber (131); the nasal powder dispenser device (100) presenting the following properties: a pressure, of the flow of compressed air generated by the air expeller (130), that is higher than 0.7 bar; and a volume, of the air chamber (131), that is greater than 1700 mm.sup.3.

Infusion devices and methods are provided for a drug delivery system and can include an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).

The invention regards an applicator tube for delivering a paste from a syringe, comprising: a delivery tube comprising a distal end for delivering the paste, and a valve system attached to a proximal end of the delivery tube and configured for attachment to the syringe, the valve system having a first configuration allowing aspiration of gas from the surroundings, and a second configuration allowing expression of aspirated gas into the delivery tube, such that the applicator tube is configured for transporting a volume of aspirated gas into and through the delivery tube when an attached syringe is aspirated and expressed.

A negative pressure assembly includes a drape, a sealing element, a reactor, and a mechanical pump assembly. The drape covers a dressing site on a patient and seals against the skin upon application of a vacuum while maintaining a negative pressure underneath the drape. When applied to the skin, the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. The reactor is located with respect to the drape and the sealing element to be in fluid communication with the enclosed volume when the drape is covering the dressing site and is configured to react with and consume a selected gas found in air. The mechanical pump assembly is connectable to the enclosed volume and has a pump chamber in fluid communication with the enclosed volume to draw air from the enclosed volume into the pump chamber.

Described herein are devices and methods of treating obstructive breathing disorders in a patient. A method may include: attaching an anchor to a dorsal region of a tongue body; applying an external force to the tongue body; and adjusting a magnitude of the external force. In some embodiments, the magnitude of the external force is adjustable across multiple levels based on one or more of: patient comfort, desired therapeutic effect, or patient wake or sleep state. In some embodiments, at least a portion of the external force is directed along an anterior direction. In some embodiments, the external force causes at least one of the following actions: anterior displacement of a portion of the posterior tongue during sleep or reducing posterior displacement of a portion of the tongue during sleep.

Methods, systems and devices for treating epistaxis are provided. In various embodiments, a nasal insert system is provided that comprises components that are operable to be at least partially inserted into a nasal cavity of a patient affected by epistaxis. Devices of the present disclosure further comprise fluid channels and conduits for selectively receiving and transmitting therapeutic agents including, but not limited to tranexamic acid.