Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

A low medicament sensor for a medicament delivery device having a reservoir, a pump, and a fluid path therebetween for medicament, the sensor including a switch and a snap dome. The snap dome is initially in contact with the switch, in fluid communication with the fluid path, and configured to snap out of contact with the switch when a pressure within the snap dome decreases below a predetermined pressure.

An infusion device includes a pump device having a housing and a flexible wall section together forming a channel extending along a channel length between first and second ends. An actuation device locally depresses the flexible wall section in a vertical direction, and is displaceable along the vertical direction. To pump a fluid through the channel, the actuation device is actuated to depress the flexible wall section at a depression location, the depression location during one pump cycle moving along the channel length. To calibrate the infusion device, the position of the actuation device along the vertical direction during one pump cycle is measured to obtain a measured profile, a difference between the measured profile and a prestored nominal profile is formed to obtain a difference profile, and from the difference profile a characteristic value for correcting and/or checking the pump operation of the infusion device is calculated.

Pressure conditioning systems for supplying insufflation gas to an open-ended body conduit such as a rectal cavity during a transanal minimally invasive surgery (TAMIS) procedure can reduce billowing of walls of the body conduit. A pressure conditioning system can include a pressure storage component, an accumulator, and a flow restrictor. The pressure storage component can include a variable volume reservoir that is biased to a relatively low volume state. The flow restrictor can include insufflation tubing with a restrictor plate having a relatively low diameter orifice. The pressure storage component, accumulator, and flow restrictor can be fluidly connected in various orders in series or as side branches from a gas flow conduit. Despite a pulsed or otherwise discontinuous insufflation gas flow and leakage and absorption from the body conduit, the pressure conditioning system can maintain a constant pressure within the body conduit.

An irrigation system for anal or stomal irrigation includes a tubing system attachable between a reservoir and a catheter. The tubing system has a proximal portion attachable to the reservoir and a distal portion including a distal end that is attachable to the catheter, with the tubing system providing an irrigation flow path from the proximal portion attachable to the reservoir through the distal end attachable to the catheter. A pump is operable to move the liquid through the irrigation flow path to provide the anal or stomal irrigation out of the catheter. A pressure control device is attachable to the distal portion of the tubing system and communicates with the catheter. The pressure control device has a valve that is adapted to limit an irrigation pressure for the anal or stomal irrigation out of the catheter to a value less than a pre-determined pressure threshold.

Systems and methods for determining the position of a fluid within a fluid source and infusion line coupled to an infusion flow control device are described herein. An exemplary system and method includes sampling fluid pressure upstream of an infusion pump, and calculating fluid pressure slope profiles. By sampling fluid pressure upstream of an infusion pump at discrete intervals and monitoring fluid pressure slope profiles, conditions of fluid flow, including unintentional fluid flow through an infusion line or a defective check valve in an infusion line, are detected, and fluid flow through an infusion pump is controlled.

Catheters for infusion of cardiovascular fluids into blood are disclosed. The cardiovascular fluid may, for example, comprise water highly supersaturated with a gas such as oxygen. Each catheter comprises one or more capillary tubings (or capillaries) through which a cardiovascular fluid flows. The distal end of each capillary is mounted (e.g., potted) preferably flush with an external surface of a catheter sidewall, while the proximal end of each capillary is in fluid communication with a cardiovascular fluid flowing through the lumen of the catheter. The combination of the catheter shape and the orientation of the distal end of each capillary relative to the longitudinal axis of the catheter provides control over the mixing pattern of the cardiovascular fluid with blood flowing within a vascular space such as an aorta.

An infusion arrangement for administering a medical fluid includes a pump apparatus with an elastomeric membrane which forms a pump volume. The elastomeric membrane is elastically extended in a fill state, filled at least partially with medical fluid, of the pump volume and produces a delivery pressure on the pump volume. An infusion line is connected to the pump volume and provided with a patient access for fluid-conducting connection. A main fluid channel transfers medical fluid from the pump volume to the patient access. A monitoring device is connected to the infusion line and configured for monitoring the pump apparatus. The monitoring device has a differential pressure-measuring element connected to the main fluid channel and designed such that differential pressure formed along a channel portion of the main fluid channel can be detected by the differential pressure-measuring element and a delivery rate of the medical fluid can be indicated.

A digital syringe is used with conventional polymer disposable syringe construction to be practical in the medical environment. Errors associated with the larger volumes of the syringes (which exacerbate minor errors in plunger position) and the flexibility and dimensional variations of the polymer plungers are accommodated by direct measurement of the syringe plunger position rather than indirect measurement of motor position and inference of syringe plunger position. This direct measurement eliminates mechanical tolerances (stack up) in the motor, gear train, and lead screw on plunger movement, an effect exacerbated by flexibility of the plunger and changes in syringe resistance and medicament viscosity, for example, with different medicaments or when the syringe is refrigerated. The digital syringe may be combined with the motor unit to provide additional versatility.

An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.